{"id":2896,"date":"2021-08-16T18:18:02","date_gmt":"2021-08-16T09:18:02","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/?page_id=2896"},"modified":"2026-03-10T09:49:52","modified_gmt":"2026-03-10T00:49:52","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/en\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Since 2010<\/p>\n

Peer-Reviewed Papers<\/span><\/p>\n

*corresponding author<\/p>\n

    \n
  1. Identification of New Cyclocircadins from Cyclocybe erebia<\/em> and Their Effects on the Circadian Rhythm of Human Osteosarcoma Cells<\/a>.
    \n<\/strong>Kota Seki, Keisuke Kariya, Ryo Miyata, Daisuke Sasaki, Yusei Kobayashi, Kotomi Ueno, Ryo C. Yanagita, Yu Tahara, Yoshihiro Nakajima, Atsushi Ishihara*.
    \nJ. Nat. Prod.<\/em>\u00a02026<\/strong>, 89<\/em>, 421\u2013432. [DOI:     10.1021\/acs.jnatprod.5c01158<\/a>]<\/li>\n
  2. Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C<\/a>.\"\"
    \n<\/strong>Mana Morishita,\u00a0Kohei Hada,\u00a0Yusuke Araki,\u00a0Keisuke Fukaya,\u00a0Daisuke Urabe,\u00a0Ryo C. Yanagita,\u00a0Jumpei Maki,\u00a0Yusuke Hanaki,\u00a0Masaki Kita,\u00a0Kazuhiro Irie,\u00a0Toshio Nishikawa*.
    \nEur. J. Org. Chem.<\/em>\u00a02025<\/strong>, 28<\/em>, e202500890. [DOI:     10.1002\/ejoc.202500890<\/a>]<\/li>\n
  3. Six-step synthesis and epithelial\u2013mesenchymal transition-inhibitory activity of a tetralone-based vitetrifolin analog<\/a>.\"\"
    \n<\/strong>Yusuke Hanaki*, Yasunori Sugiyama, Ryo C. Yanagita.
    \nBiosci. Biotechnol. Biochem.<\/em>\u00a02025<\/strong>, 89, 805\u2013810. [DOI:     10.1093\/bbb\/zbaf030<\/a>] [Pubmed: 40058878<\/a>]<\/a><\/li>\n
  4. Validation of Machine Learning-assisted Screening of PKC Ligands: PKC Binding Affinity and Activation<\/a>.
    \n<\/strong>Jumpei Maki,\u00a0Asami Oshimura,\u00a0Yudai Shiotani,\u00a0Maki Yamanaka,\u00a0Sogen Okuda,\u00a0Ryo C. Yanagita,\u00a0Shigeru Kitani,\u00a0Yasuhiro Igarashi,\u00a0Yutaka Saito,\u00a0Yasubumi Sakakibara, Chihiro Tsukano,\u00a0Kazuhiro Irie*.
    \nBiosci. Biotechnol. Biochem.<\/em>\u00a02025<\/strong>, 89, 668\u2013679. [DOI:     10.1093\/bbb\/zbaf008<\/a>] [Pubmed: 39863420<\/a>]<\/li>\n
  5. Identification of sesquiterpene aldehydes as volatile antifungal compounds in\u00a0Phaeolepiota aurea<\/em>\u00a0culture filtrate<\/strong><\/a>.
    \nKota Seki, Tomoya Tanaka, Emiko Shimoda, Shinji Tanio, Ryo C. Yanagita, Tsugumi Miyazaki, Kento Tokumoto, Toshiaki Tazawa, Kumiko Osaki-Oka, Atsushi Ishihara*.
    \nBiosci. Biotechnol. Biochem.<\/em>\u00a02024<\/strong>, 88, 1395\u20131402. [DOI:     10.1093\/bbb\/zbae125<\/a>] [Pubmed: 39237456<\/a>]<\/li>\n
  6. Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R<\/em>)-(\u2212)-carvone-based core<\/b><\/a>.
    \nRyo C. Yanagita*, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.
    \nBiosci. Biotechnol. Biochem.<\/i>\u00a02024<\/strong>, 88, 992\u2013998. [DOI:     10.1093\/bbb\/zbae091<\/a>] [Pubmed: 38936828<\/a>] \u00a0[Accepted Manuscript\"\"<\/strong><\/a>]<\/span>\"\"<\/li>\n
  7. A new labdane-type diterpenoid from leaves of Vitex rotundifolia<\/em><\/strong><\/a>. \"\"
    \nYusuke Hanaki*, Rintaro Abe, Yasunori Sugiyama, Yasumasa Hara, Ryo C. Yanagita.
    \nResults Chem.<\/i>\u00a02024<\/strong>, 7, 101512. [DOI:     10.1016\/j.rechem.2024.101512<\/a>]<\/span><\/li>\n
  8. Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation<\/strong><\/a>.
    \nJumpei Maki, Yusuke Hanaki, Ryo C. Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie*.
    \nBiosci. Biotechnol. Biochem.<\/i>\u00a02023<\/strong>, 87, 1453\u20131461. [DOI:     10.1093\/bbb\/zbad128<\/a>] [Pubmed: 37682524<\/a>]<\/span><\/li>\n
  9. Cell Morphology-Based Screening Identified Vitetrifolin D from\u00a0Vitex rotundifolia<\/i> as an Inhibitor of Phorbol Ester\u2013Induced Downregulation of E-Cadherin in HHUA Endometrial Cells<\/strong><\/a>. \"\"
    \nYusuke Hanaki*, Nichika Iwase, Yasunori Sugiyama, Sena Miyoshi, Ryo C. Yanagita.
    \nBPB Reports<\/i>\u00a02023<\/strong>, 6, 103\u2013107. [DOI:     10.1248\/bpbreports.6.3_103<\/a>]<\/span><\/li>\n
  10. A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities<\/strong><\/a>.
    \nTomoki Sekido, Kosuke Yamamoto, Ryo C. Yanagita*, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.
    \nBioorg. Med. Chem.<\/i>\u00a02022<\/strong>, 73, 116988. [DOI:     10.1016\/j.bmc.2022.116988<\/a>] [Pubmed: 36113282<\/a>] \u00a0[Accepted Manuscript\"\"<\/strong><\/a>]<\/span>\"\"<\/li>\n
  11. 12-O<\/em>-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial\u2013mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases<\/strong><\/a>.
    \nYusuke Hanaki*, Sena Miyoshi, Yasunori Sugiyama, Ryo C. Yanagita, Masashi Sato.
    \nBiosci. Biotechnol. Biochem.<\/i>\u00a02022<\/strong>, 86, 1417\u20131422. [DOI:     10.1093\/bbb\/zbac136<\/a>] [Pubmed: 35973688<\/a>]<\/span><\/li>\n
  12. Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid \u03b240 Trimer Models<\/a><\/strong>.
    \nAyumi Uchino, Yumi Irie, Chihiro Tsukano, Taiji Kawase, Kenji Hirose, Yusuke Kageyama, Ikuo Tooyama, Ryo C. Yanagita, Kazuhiro Irie*.
    \nACS Chem. Neurosci.<\/i>\u00a02022<\/strong>, 13, 2517\u20132528. [DOI:     10.1021\/acschemneuro.2c00363<\/a>] [Pubmed: 35930616<\/a>]<\/span><\/li>\n
  13. Structural basis of the 24B3 antibody against the toxic conformer of amyloid \u03b2 with a turn at positions 22 and 23<\/a><\/strong>.
    \nYumi Irie, Yuka Matsushima, Akiko Kita, Kunio Miki, Tatsuya Segawa, Masahiro Maeda, Ryo C. Yanagita, Kazuhiro Irie*.
    \nBIochem. Biophys. Res. Commun.<\/i>\u00a02022<\/strong>, 621, 162\u2013167. [DOI:     10.1016\/j.bbrc.2022.07.010<\/a>] [Pubmed: 35839743<\/a>]<\/span><\/li>\n
  14. Design, synthesis, and biological activity of synthetically-accessible analog of aplysiatoxin with (R<\/em>)-(\u2212)-carvone-based conformation-controlling unit<\/strong><\/a>.
    \nYoshiyuki Suzuki, Keiichi Moritoki, Mizuki Kajiwara, Ryo C. Yanagita*, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.
    \nBiosci. Biotechnol. Biochem.<\/i>\u00a02022<\/strong>, 86, 1013\u20131023. [DOI:     10.1093\/bbb\/zbac084<\/a>] [Pubmed: 35648459<\/a>] <\/span>[Accepted Manuscript\"\"<\/strong><\/a>]<\/span>\"\"<\/li>\n
  15. AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity<\/a><\/strong>.
    \nJumpei Maki, Asami Oshimura, Chihiro Tsukano, Ryo C. Yanagita, Yutaka Saito, Yasubumi Sakakibara, Kazuhiro Irie*.
    \nChem. Commun.<\/i>\u00a02022<\/strong>, 58, 6693\u20136696. [DOI:     10.1039\/D2CC01759H<\/a>] [Pubmed: 35608215<\/a>]<\/span><\/li>\n
  16. Analysis of binding mode of vibsanin A with protein kinase C C1 domains: An experimental and molecular dynamics simulation study<\/strong><\/a>.
    \nRyo C. Yanagita*, Mao Otani, Satoshi Hatanaka, Hiroto Nishi, Shota Miyake, Yusuke Hanaki, Masashi Sato, Yasuhiro Kawanami, Kazuhiro Irie.
    \nJ. Mol. Struct.<\/i>\u00a02022<\/strong>, 1260, 132866. [DOI:     10.1016\/j.molstruc.2022.132866<\/a>] \u00a0[Accepted Manuscript\"\"<\/strong><\/a>]<\/span>\"\"<\/li>\n
  17. Structure optimization of the toxic conformation model of amyloid \u03b242 by intramolecular disulfide bond formation<\/strong><\/a>.
    \nYuka Matsushima, Yumi Irie, Yusuke Kageyama, Jean-Pierre Bellier, Ikuo Tooyama, Takahito Maki, Toshiaki Kume, Ryo C. Yanagita, Kazuhiro Irie*.
    \nChemBioChem<\/i>\u00a02022<\/strong>, 23, e202200029. [DOI:     10.1002\/cbic.202200029<\/a>] [Pubmed: 35165998<\/a>]<\/span><\/li>\n
  18. Evaluation of the in vitro<\/em> cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions<\/a><\/strong>.\u00a0\"\"
    \nYusuke Hanaki*, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita.
    \nFundam. Toxicol. Sci<\/em>. 2021<\/strong>, 8, 69\u201373. [DOI:     10.2131\/fts.8.69<\/a>]<\/span><\/li>\n
  19. Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities<\/strong><\/a>.
    \nAtsuko Gonda, Koji Takada, Ryo C. Yanagita, Shingo Dan, Kazuhiro Irie*.
    \nBiosci. Biotechnol. Biochem. <\/span>2021<\/span>, 85<\/span>, 168\u2013180. [DOI:     10.1093\/bbb\/zbaa024<\/a>] [Pubmed: 33577665<\/a>]<\/span><\/li>\n
  20. Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH\/\u03c0 interaction<\/strong><\/a>.
    \nTakumi Kobayashi, Ryo C. Yanagita, Kazuhiro Irie*.
    \nBioorg. Med. Chem. Lett.<\/span> 2021<\/span>, 30<\/span>, 127657. [DOI:     10.1016\/j.bmcl.2020.127657<\/a>] [Pubmed: 33130291<\/a>]<\/span><\/li>\n
  21. Evaluation of the Anti-Proliferative Activity of Rare Aldohexoses against MOLT-4F and DU-145 Human Cancer Cell Line and Structure-Activity Relationship of D-Idose.<\/span><\/a>\u00a0\"\"
    \nHironobu Ishiyama, Ryo C. Yanagita*, Kazune Takemoto, Natsumi Kitaguchi, Yuuki Uezato, Yasunori Sugiyama, Masashi Sato, Yasuhiro Kawanami.
    \nJ. Appl. Glycosci.<\/span> 2020<\/span>, 67<\/span>, 95\u2013101. [DOI:     10.5458\/jag.jag.JAG-2020_0006<\/a>] [Pubmed: 34354535<\/a>]<\/span><\/li>\n
  22. Control of the toxic conformation of amyloid \u03b242 by intramolecular disulfide bond formation.<\/span><\/a>
    \nYuka Matsushima, Ryo C. Yanagita, Kazuhiro Irie*.
    \nChem. Commun.<\/span> 2020<\/span>, 56<\/span>, 4118\u20134121. [DOI:     10.1039\/D0CC01053G<\/a>] [Pubmed: 32163091<\/a>]<\/span><\/li>\n
  23. Nematocidal Activity of 6-O<\/span>-octanoyl- And 6-O<\/span>-octyl-D-allose Against Larvae of Caenorhabditis elegans<\/span>.<\/span><\/span><\/a>
    \nHirofumi Sakoguchi, Tomoya Shintani, Hironobu Ishiyama, Ryo C. Yanagita, Yasuhiro Kawanami, Masashi Sato*.
    \nBiosci. Biotechnol. Biochem.<\/span> 2019<\/span>, 83<\/span>\u00a0(12), 2194\u20132197. [DOI:     10.1080\/09168451.2019.1648206<\/a>] [Pubmed: 31357905<\/a>]<\/span><\/li>\n
  24. Synthesis, Conformation, and Biological Activities of a Des-A-Ring Analog of 18-Deoxy-aplog-1, a Simplified Analog of Debromoaplysiatoxin.<\/span><\/a>
    \nYoshiki Ashida, Ryo C. Yanagita*, Yasuhiro Kawanami, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie.
    \nHeterocycles<\/span> 2019<\/span>, 99<\/span>\u00a0(2), 942\u2013957. [DOI:     10.3987\/COM-18-S(F)60<\/a>] <\/span>[CLOCKSS<\/a>\"\"] [Accepted Manuscript\"\"<\/strong><\/a>] [SI<\/strong><\/a> \"\"<\/strong><\/a>]<\/span>
    \n\"\"<\/li>\n
  25. Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid \u03b240 with a toxic conformation.<\/span><\/a>
    \nYumi Irie, Mizuho Hanaki, Kazuma Murakami, Tsuneo Imamoto, Takumi Furuta, Takeo Kawabata, Taiji Kawase, Kenji Hirose, Yoko Monobe, Ken-ichi Akagi, Ryo C. Yanagita, Kazuhiro Irie*.
    \nChem. Commun.<\/span> 2019<\/span>, 55<\/span>\u00a0(2), 182\u2013185. [DOI:     10.1039\/C8CC08618D<\/a>] <\/span> [Pubmed: 30519688<\/a>]<\/li>\n
  26. Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, a Potential Anti-Cancer Lead Derived from Debromoaplysiatoxin<\/a>.<\/span>
    \nKoutaro Hayakawa, Yusuke Hanaki, Harukuni Tokuda, Ryo C. Yanagita, Yu Nakagawa, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie*.
    \nHeterocycles<\/span> 2018<\/span>, 97<\/span>\u00a0(1), 478\u2013492. [DOI:     10.3987\/COM-18-S(T)37<\/a>] <\/span>[CLOCKSS<\/a>\"\"]\u00a0[Accepted Manuscript\"\"<\/strong><\/a>] [SI<\/strong><\/a> \"\"<\/strong><\/a>]<\/span><\/li>\n
  27. Synthesis and inhibitory activity of deoxy-D<\/span>-allose amide derivative against plant growth.<\/span><\/a>
    \nMd. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami*.
    \nBiosci. Biotechnol. Biochem.<\/span> 2018<\/span>, 82<\/span>\u00a0(5), 775\u2013779. [DOI:     10.1080\/09168451.2018.1445521<\/a>] [Pubmed: 29513080<\/a>] <\/span><\/li>\n
  28. Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.<\/span><\/a>\u00a0\"\"
    \nYusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie*.
    \nMolecules<\/span> 2017<\/span>, 22<\/span>\u00a0(4), E631. [DOI:     10.3390\/molecules22040631<\/a>] [Pubmed: 28406454<\/a>] <\/span><\/li>\n
  29. Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure\u2013activity study on simplified analogs of the receptor-recognition domain<\/span><\/a>.
    \nYoshiki Ashida, Ryo C. Yanagita*, Chise Takahashi, Yasuhiro Kawanami, Kazuhiro Irie.
    \nBioorg. Med. Chem<\/span>. 2016<\/span>, 24<\/span>\u00a0(18), 4218-4227. [DOI:     10.1016\/j.bmc.2016.07.011<\/a>] [Pubmed: 27436807<\/a>] [Accepted Manuscript\"\"<\/strong><\/a>]\n\"1-s2-0-s096808961630503x-fx1\"<\/span><\/li>\n
  30. Syntheses and biological activities of deoxy-D<\/span>-allose fatty acid ester analogs<\/span><\/a>.
    \nMd. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami*.
    \nBiosci. Biotechnol. Biochem<\/span>. 2016<\/span>, 80<\/span> (4), 676-681. [DOI:     10.1080\/09168451.2015.1132151<\/a>] [Pubmed: 26822163<\/a>]<\/span><\/li>\n
  31. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead<\/span><\/a>.
    \nMasayuki Kikumori, Ryo C. Yanagita, Harukuni Tokuda, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie*.
    \nBiosci. Biotechnol. Biochem<\/span>. 2016<\/span>, 80<\/span> (2) 221-231. [DOI:     10.1080\/09168451.2015.1091718<\/a>] [Pubmed: 26452398<\/a>]<\/span><\/li>\n
  32. Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities<\/span><\/a>.
    \nYusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*.
    \nBiosci. Biotechnol. Biochem<\/span>. 2015<\/span>, 79<\/span> (6) 888-895. [DOI:     10.1080\/09168451.2014.1002452<\/a>] [Pubmed: 25612633<\/a>]<\/span><\/li>\n
  33. Effect of BF3<\/sub> on the enantioselective reduction of trifluoromethyl ketones using a chiral lactam alcohol with borane<\/span><\/a>.
    \nYuki Harauchi, Chihiro Takakura, Toshio Furumoto, Ryo C. Yanagita, Yasuhiro Kawanami*.
    \nTetrahedron: Asymmetry <\/span>2015<\/span>, 26<\/span> (7) 333-337. [DOI:     10.1016\/j.tetasy.2015.02.011<\/a>]<\/span><\/li>\n
  34. Synthesis of 6-O<\/span>-decanoyl-D<\/span>-altrose and 6-O<\/span>-decanoyl-D<\/span>-gulose and evaluation of their biological activity on plant growth<\/span><\/a>.
    \nMd. Tazul Islam Chowdhury, Madoka Naito, Ryo C. Yanagita, Yaushiro Kawanami*.
    \nPlant Growth Regul<\/span>. 2015<\/span>, 75<\/span> (3) 707-713. [DOI:     10.1007\/s10725-014-9972-2<\/a>]<\/span><\/li>\n
  35. Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug<\/span><\/a>.
    \nMasayuki Kikumori, Ryo C. Yanagita, Kazuhiro Irie*.
    \nTetrahedron<\/span> 2014<\/span>, 70<\/span> (52) 9776-9782. [DOI:     10.1016\/j.tet.2014.11.026<\/a>]<\/span><\/li>\n
  36. Anti-proliferative activity of 6-O<\/span>-acyl-D<\/span>-allose against the human leukemia MOLT-4F cell line<\/span><\/a>.
    \nRyo C. Yanagita*, Katsuya Kobashi, Chisa Ogawa, Yoshiki Ashida, Haruka Yamaashi, Yasuhiro Kawanami.
    \nBiosci. Biotechnol. Biochem<\/span>. 2014<\/span>,\u00a0 78<\/span> (2) 190-194. [DOI:     10.1080\/09168451.2014.882747<\/a>] [Pubmed: 25036670<\/a>]<\/span>
    \n\"allose1\"<\/li>\n
  37. Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction<\/span><\/a>.
    \nYuming Wang, Jiahui Wang, Ryo C. Yanagita, Chunhua Liu, Xiaoqian Hu, Ping Dong, Changhu Xue*, Yong Xue*.
    \nBiosci. Biotechnol. Biochem<\/span>. 2014<\/span>, 78<\/span> (1) 139-146. [DOI:     10.1080\/09168451.2014.877830<\/a>] [Pubmed: 25036496<\/a>]<\/span><\/li>\n
  38. Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities<\/span><\/a>.
    \nRyo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie*.
    \nBioorg. Med. Chem. Lett<\/span>. 2013<\/span>, 23<\/span> (15) 4319-4323. [DOI:     10.1016\/j.bmcl.2013.05.096<\/a>] [Pubmed: 23803585<\/a>]<\/span>
    \n\"1-s2-0-s0960894x13007026-fx1\"<\/li>\n
  39. Structure\u2013activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity<\/span><\/a>.
    \nHiroaki Kamachi, Keisuke Tanaka, Ryo C. Yanagita, Akira Murakami, Kazuma Murakami, Harukuni Tokuda, Nobutaka Suzuki, Yu Nakagawa, Kazuhiro Irie*.
    \nBioorg. Med. Chem<\/span>. 2013<\/span>, 21<\/span> (10) 2695-2702. [DOI:     10.1016\/j.bmc.2013.03.013<\/a>] [Pubmed: 23582444<\/a>]<\/span><\/li>\n
  40. Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures<\/span>.<\/a>
    \nYuki Shu, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*.
    \nHeterocycles<\/span> 2012<\/span>, 8<\/span>6 (1) 281-303. [DOI:     10.3987\/COM-12-S(N)8<\/a><\/span>]\u00a0<\/span>[CLOCKSS<\/a>\"\"]\u00a0[Accepted Manuscript\"\"<\/strong><\/a>]<\/span><\/li>\n
  41. Identification and biolofical activities of bryostatins from Japanese bryozoan<\/span><\/a>.
    \nSayo Ueno. Ryo C. Yanagita, Kazuma Murakami, Akira Murakami, Harukuni Tokuda, Nobutaka Suzuki, Takeshi Fujiwara, Kazuhiro Irie*.
    \nBiosci. Biotechnol. Biochem<\/span>. 2012<\/span>, 76<\/span> (5) 1041-1043. [DOI:     10.1271\/bbb.120026<\/a>] [Pubmed: 22738985<\/a>]<\/span><\/li>\n
  42. Structure\u2013activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activit<\/span>y<\/a>.
    \nMasayuki Kikumori. Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Kazuhiro Irie*.
    \nJ. Med. Chem<\/span>. 2012<\/span>, 55<\/span> (11) 5614-5626. [DOI:     10.1021\/jm300566h<\/a>] [Pubmed: 22625994<\/a>]<\/span><\/li>\n
  43. Synthesis and structure\u2013activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1<\/span><\/a>.
    \nKazuhiro Irie*, Masayuki Kikumori, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Yu Nakagawa.
    \nPure Appl. Chem<\/span>. 2012<\/span>, 84<\/span> (6) 1341-1351. [DOI:     10.1351\/PAC-CON-11-08-22<\/a>]<\/span><\/li>\n
  44. Enantioselective reduction of \u03b1,\u03b2-enones using an oxazaborolidine catalyst generated in situ from a chiral lactam alcohol<\/span><\/a>.
    \nYasuhiro Kawanami*, Yudai Mikami, Kazuya Kiguchi, Yuki Harauchi, Ryo C. Yanagita.
    \nTetrahedron: Asymmetry<\/span>\u00a02011<\/span>, 22<\/span> (20\u201422), 1891\u20131894. [DOI:     10.1016\/j.tetasy.2011.10.018<\/a>]<\/span><\/li>\n
  45. Generation of \u2018unnatural natural product\u2019 library and identification of a small molecule inhibitor of XIAP<\/span><\/a>.
    \nTatsuro Kawamura, Kohei Matsubara, Hitomi Otaka, Etsu Tashiro, Kazutoshi Shindo, Ryo C. Yanagita, Kazuhiro Irie, Masaya Imoto*.
    \nBioorg. Med. Chem<\/span>. 2011<\/span>, 19<\/span> (14), 4377\u20134385. [DOI:     10.1016\/j.bmc.2011.05.009<\/a>]\u00a0 [PubMed: 21696964<\/a>]<\/span><\/li>\n
  46. Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin<\/span><\/a>.
    \nYu Nakagawa, Masayuki Kikumori, Ryo C. Yanagita, Akira Murakami, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie*.
    \nBiosci. Biotechnol. Biochem<\/span>. 2011<\/span>, 75<\/span> (6),\u00a0\u00a0 1167\u20131173.\u00a0\u00a0 [DOI:     10.1271\/bbb.110130<\/a>] [PubMed: 21670518<\/a>]<\/span><\/li>\n
  47. Role of the phenolic hydroxyl Group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity<\/span><\/a>.
    \nRyo C. Yanagita, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Yu Nakagawa, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie*.
    \nBioorg. Med. Chem. Lett<\/span>. 2010<\/span>, 20<\/span> (20), 6064\u20136066.\u00a0\u00a0 [DOI:     10.1016\/j.bmcl.2010.08.051<\/a>] [PubMed: 20817520<\/a>]<\/span>
    \n\"1-s2-0-s0960894x10011741-fx1\"<\/li>\n<\/ol>\n

    Non-Peer-Reviewed Papers<\/span><\/p>\n

      \n
    1. Inhibitory activity of 6-O<\/em>-decyl-D-allose and 6-(decanoylamino)-6-deoxy-D-allose against plant growth<\/span><\/a>.
      \nHaruka Yamaashi, Md. Tazul Islam Chowdhury, Ryo C. Yanagita, Yasuhiro Kawanami.
      \nTech. Bull. Fac. Agr. Kagawa Univ. <\/em>2017<\/span>, 69<\/i> (122), 17\u201322.<\/li>\n<\/ol>\n

      Book Chapters and Reviews<\/span><\/p>\n

        \n
      1. Practical Enantioselective Reduction of Ketones Using Oxazaborolidine Catalysts Generated In Situ from Chiral Lactam Alcohols.<\/span><\/a>\u00a0\"\"
        \nYasuhiro Kawanami*, Ryo C. Yanagita.
        \nMolecules<\/span> 2018<\/span>, 23<\/span>\u00a0(10), E2408. [DOI:         10.3390\/molecules23102408<\/a>] [Pubmed: 30241305<\/a>] <\/span><\/li>\n
      2. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin<\/span><\/a>.
        \nKazuhiro Irie*, Ryo C. Yanagita.
        \nChem. Rec<\/span>. 2014<\/span>, 14<\/span> (2), 251\u2013267.\u00a0\u00a0 [DOI:         10.1002\/tcr.201300036<\/a>] [PubMed: 24677503<\/a>]<\/span><\/li>\n
      3. Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism for protein kinase C\u03b4<\/span><\/a>.
        \nKazuhiro Irie*, Ryo C. Yanagita, Yu Nakagawa.
        \nMed. Res. Rev<\/span>. 2012<\/span>, 32<\/span> (3), 518\u2013535.\u00a0 [DOI:         10.1002\/med.20220<\/a>] [PubMed: 21064191<\/a>]<\/span><\/li>\n<\/ol>\n

        Archives for pre-2009 papers<\/p>\n

        Peer-Reviewed Papers<\/span><\/p>\n

        *corresponding author<\/p>\n

          \n
        1. Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes<\/span><\/a>.
          \nRyo C. Yanagita, Keiji Torii, Yu Nakagawa, Kazuhiro Irie*.
          \nHeterocycles<\/i>\u00a02007<\/span>, 73<\/span> (1), 289\u2013302.\u00a0 [DOI:           10.3987\/COM-07-S(U)3<\/a>]<\/span>\u00a0[CLOCKSS<\/a>\"\"]\u00a0[Accepted Manuscript\"\"<\/strong><\/a>]<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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