{"id":8,"date":"2016-10-13T18:19:37","date_gmt":"2016-10-13T09:19:37","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/?page_id=8"},"modified":"2021-08-03T15:26:24","modified_gmt":"2021-08-03T06:26:24","slug":"curriculum-vitae","status":"publish","type":"page","link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/curriculum-vitae\/","title":{"rendered":"Curriculum Vitae"},"content":{"rendered":"<p class=\"paragraph_style\" style=\"text-align: right;\"><a href=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/curriculum-vitae\/curriculum-vitae\/\">\u65e5\u672c\u8a9e<\/a><\/p>\n<p class=\"paragraph_style\" style=\"text-align: center;\"><big><a href=\"https:\/\/researchmap.jp\/read0153343\/?lang=english\">Ryo C. Yanagita<\/a>, Ph.D.<\/big><br \/>\n<span style=\"font-size: small;\">Kagawa University, 3092, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0795, Japan<br \/>\nTel &amp; Fax: +81 (87) 891-3092<br \/>\nEmail: yanagita.ryo@kagawa-u.ac.jp<\/span><\/p>\n<p class=\"paragraph_style\" style=\"text-align: right;\"><span style=\"font-size: small;\">Last Updated: August, 2021<\/span><\/p>\n<p><span style=\"font-weight: bold;\">Research Interest<\/span>:<\/p>\n<ul>\n<li>Development of therapeutic leads based on natural products<\/li>\n<li>Mechanism of action of biologically active natural products<\/li>\n<li>Rational drug design using computational methods<\/li>\n<\/ul>\n<p class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\"> Education<\/span>:<\/p>\n<ul>\n<li class=\"paragraph_style\" style=\"text-align: left;\">2006\u20132009 &nbsp;Ph.D. [Advisor: Prof. Kazuhiro Irie] Kyoto University, Graduate School of Agriculture<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">2004\u20132006 &nbsp;M.Agr. [Advisor: Profs. Hajime Ohigashi and Kazuhiro Irie] Kyoto University, Graduate School of Agriculture<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">2000\u20132004 &nbsp;B.Agr. [Advisor: Prof. Takaaki Nishioka] Kyoto University, Faculty of Agriculture<\/li>\n<\/ul>\n<p class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\"> Position<\/span>:<\/p>\n<ul>\n<li class=\"paragraph_style\" style=\"text-align: left;\">10\/2016\u2013 &nbsp; Associate&nbsp;Professor, Kagawa University, Faculty of Agriculture, Department of Applied Biological Science, Kagawa, Japan<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">10\/2010\u20139\/2016 &nbsp;Assistant Professor, Kagawa University, Faculty of Agriculture, Department of Applied Biological Science, Kagawa, Japan<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">4\/2010\u20139\/2010 &nbsp;Lecturer (part-time), Kyoto University, Kyoto, Japan<\/li>\n<\/ul>\n<p><span style=\"font-weight: bold;\">Postdoctoral Training<\/span>:<\/p>\n<ul>\n<li class=\"paragraph_style\" style=\"text-align: left;\">4\/2010\u20139\/2010 &nbsp;Postdoctral Research Fellow, Kyoto University, Graduate School of Agriculture, Kyoto, Japan [Advisor: Prof. Kazuhiro Irie]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">4\/2009\u20133\/2010 &nbsp;Research Fellow (PD) of the Japan Society for the Promotion of Science (JSPS), Kyoto University, Graduate School of Agriculture, Kyoto, Japan<\/li>\n<\/ul>\n<p class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Predoctoral Training<\/span>:<\/p>\n<ul>\n<li class=\"paragraph_style\" style=\"text-align: left;\">4\/2008\u20133\/2009&nbsp;&nbsp;Research Fellow (DC2) of JSPS, Kyoto University, Graduate School of Agriculture, Kyoto, Japan<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">2004\u20132009 &nbsp;Teaching Assistant, Kyoto University, Graduate School of Agriculture, Kyoto, Japan<\/li>\n<\/ul>\n<p class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Membership<\/span>:<\/p>\n<ul>\n<li class=\"paragraph_style\" style=\"text-align: left;\">2004\u2013 &nbsp;Japan Society of Bioscience, Biotechnology, and Agrochemistry\uff08\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\uff09<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">2013\u2013&nbsp;&nbsp;American Chemical Society<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\">2019\u2013&nbsp;&nbsp;The Society of Synthetic Organic Chemistry, Japan<\/li>\n<\/ul>\n<p class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">PUBLICATION<\/span>:<br \/>\n<span style=\"font-weight: bold; font-style: italic;\">Peer-Reviewed Papers<\/span><\/p>\n<ol reversed=\"reversed\">\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Practical Enantioselective Reduction of Ketones Using Oxazaborolidine Catalysts Generated In Situ from Chiral Lactam Alcohols.<\/span><br \/>\nYasuhiro Kawanami, Ryo C. Yanagita.<br \/>\n<span style=\"font-style: italic;\">Molecules<\/span> <span style=\"font-weight: bold;\">2018<\/span>, <span style=\"font-style: italic;\">23<\/span>&nbsp;(10), E2408. <span style=\"font-size: small;\">[DOI: <a href=\"http:\/\/dx.doi.org\/10.3390\/molecules23102408\">10.3390\/molecules23102408<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30241305 \">30241305<\/a>] <\/span><\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis and inhibitory activity of deoxy-<span style=\"font-size: small;\">D<\/span>-allose amide derivative against plant growth.<\/span><br \/>\nMd. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem.<\/span> <span style=\"font-weight: bold;\">2018<\/span>, <span style=\"font-style: italic;\">82<\/span>&nbsp;(5), 775\u2013779. <span style=\"font-size: small;\">[DOI: <a href=\"http:\/\/dx.doi.org\/10.1080\/09168451.2018.1445521\">10.1080\/09168451.2018.1445521<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29513080\">29513080<\/a>] <\/span><\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.<\/span><br \/>\nYusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Molecules<\/span> <span style=\"font-weight: bold;\">2017<\/span>, <span style=\"font-style: italic;\">22<\/span>&nbsp;(4), E631. <span style=\"font-size: small;\">[DOI: <a href=\"http:\/\/dx.doi.org\/10.3390\/molecules22040631\">10.3390\/molecules22040631<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28406454\">28406454<\/a>] <\/span><\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure\u2013activity study on simplified analogs of the receptor-recognition domain<\/span>.<br \/>\nYoshiki Ashida, Ryo C. Yanagita, Chise Takahashi, Yasuhiro Kawanami, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Bioorg. Med. Chem<\/span>. <span style=\"font-weight: bold;\">2016<\/span>, <span style=\"font-style: italic;\">24<\/span>&nbsp;(18), 4218-4227. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bmc.2016.07.011\">10.1016\/j.bmc.2016.07.011<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27436807\">27436807<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Syntheses and biological activities of deoxy-<span style=\"font-size: small;\">D<\/span>-allose fatty acid ester analogs<\/span>.<br \/>\nMd. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem<\/span>. <span style=\"font-weight: bold;\">2016<\/span>, <span style=\"font-style: italic;\">80<\/span> (4), 676-681. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1080\/09168451.2015.1132151\">10.1080\/09168451.2015.1132151<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26822163\">26822163<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead<\/span>.<br \/>\nMasayuki Kikumori, Ryo C. Yanagita, Harukuni Tokuda, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem<\/span>. <span style=\"font-weight: bold;\">2016<\/span>, <span style=\"font-style: italic;\">80<\/span> (2) 221-231. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1080\/09168451.2015.1091718\">10.1080\/09168451.2015.1091718<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26452398\">26452398<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities<\/span>.<br \/>\nYusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem<\/span>. <span style=\"font-weight: bold;\">2015<\/span>, <span style=\"font-style: italic;\">79<\/span> (6) 888-895. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1080\/09168451.2014.1002452\">10.1080\/09168451.2014.1002452<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25612633\">25612633<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Effect of BF<sub>3<\/sub> on the enantioselective reduction of trifluoromethyl ketones using a chiral lactam alcohol with borane<\/span>.<br \/>\nYuki Harauchi, Chihiro Takakura, Toshio Furumoto, Ryo C. Yanagita, Yasuhiro Kawanami.<br \/>\n<span style=\"font-style: italic;\">Tetrahedron: Asymmetry <\/span><span style=\"font-weight: bold;\">2015<\/span>, <span style=\"font-style: italic;\">26<\/span> (7) 333-337. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.tetasy.2015.02.011\">10.1016\/j.tetasy.2015.02.011<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis of 6-<span style=\"font-style: italic;\">O<\/span>-decanoyl-<span style=\"font-size: small;\">D<\/span>-altrose and 6-<span style=\"font-style: italic;\">O<\/span>-decanoyl-<span style=\"font-size: small;\">D<\/span>-gulose and evaluation of their biological activity on plant growth<\/span>.<br \/>\nMd. Tazul Islam Chowdhury, Madoka Naito, Ryo C. Yanagita, Yaushiro Kawanami.<br \/>\n<span style=\"font-style: italic;\">Plant Growth Regul<\/span>. <span style=\"font-weight: bold;\">2015<\/span>, <span style=\"font-style: italic;\">75<\/span> (3) 707-713. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1007\/s10725-014-9972-2\">10.1007\/s10725-014-9972-2<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug<\/span>.<br \/>\nMasayuki Kikumori, Ryo C. Yanagita, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Tetrahedron<\/span> <span style=\"font-weight: bold;\">2014<\/span>, <span style=\"font-style: italic;\">70<\/span> (52) 9776-9782. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.tet.2014.11.026\">10.1016\/j.tet.2014.11.026<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Anti-proliferative activity of 6-<span style=\"font-style: italic;\">O<\/span>-acyl-<span style=\"font-size: small;\">D<\/span>-allose against the human leukemia MOLT-4F cell line<\/span>.<br \/>\nRyo C. Yanagita, Katsuya Kobashi, Chisa Ogawa, Yoshiki Ashida, Haruka Yamaashi, Yasuhiro Kawanami.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem<\/span>. <span style=\"font-weight: bold;\">2014<\/span>,&nbsp; <span style=\"font-style: italic;\">78<\/span> (2) 190-194. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1080\/09168451.2014.882747\">10.1080\/09168451.2014.882747<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25036670\">25036670<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction<\/span>.<br \/>\nYuming Wang, Jiahui Wang, Ryo C. Yanagita, Chunhua&nbsp;Liu, Xiaoqian Hu, Ping Dong, Changhu Xue, Yong Xue.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem<\/span>. <span style=\"font-weight: bold;\">2014<\/span>, <span style=\"font-style: italic;\">78<\/span> (1) 139-146. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1080\/09168451.2014.877830\">10.1080\/09168451.2014.877830<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25036496\">25036496<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities<\/span>.<br \/>\nRyo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Bioorg. Med. Chem. Lett<\/span>. <span style=\"font-weight: bold;\">2013<\/span>, <span style=\"font-style: italic;\">23<\/span> (15) 4319-4323. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bmcl.2013.05.096\">10.1016\/j.bmcl.2013.05.096<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23803585\">23803585<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Structure\u2013activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity<\/span>.<br \/>\nHiroaki Kamachi, Keisuke Tanaka, Ryo C. Yanagita, Akira Murakami, Kazuma Murakami, Harukuni Tokuda, Nobutaka Suzuki, Yu Nakagawa, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Bioorg. Med. Chem<\/span>. <span style=\"font-weight: bold;\">2013<\/span>, <span style=\"font-style: italic;\">21<\/span> (10) 2695-2702. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bmc.2013.03.013\">10.1016\/j.bmc.2013.03.013<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23582444\">23582444<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures<\/span>.<br \/>\nYuki Shu, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Heterocycles<\/span> <span style=\"font-weight: bold;\">2012<\/span>, <span style=\"font-style: italic;\">8<\/span>6 (1) 281-303. [DOI: <a href=\"http:\/\/dx.doi.org\/10.3987\/COM-12-S(N)8\">10.3987\/COM-12-S(N)8<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Identification and biolofical activities of bryostatins from Japanese bryozoan<\/span>.<br \/>\nSayo Ueno. Ryo C. Yanagita, Kazuma Murakami, Akira Murakami, Harukuni Tokuda, Nobutaka Suzuki, Takeshi Fujiwara, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem<\/span>. <span style=\"font-weight: bold;\">2012<\/span>, <span style=\"font-style: italic;\">76<\/span> (5) 1041-1043. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1271\/bbb.120026\">10.1271\/bbb.120026<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22738985\">22738985<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Structure\u2013activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activit<\/span>y.<br \/>\nMasayuki Kikkumori. Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">J. Med. Chem<\/span>. <span style=\"font-weight: bold;\">2012<\/span>, <span style=\"font-style: italic;\">55<\/span> (11) 5614-5626. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jm300566h\">10.1021\/jm300566h<\/a>] [Pubmed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22625994\">22625994<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis and structure\u2013activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1<\/span>.<br \/>\nKazuhiro Irie, Masayuki Kikumori, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Yu Nakagawa.<br \/>\n<span style=\"font-style: italic;\">Pure Appl. Chem<\/span>. <span style=\"font-weight: bold;\">2012<\/span>, <span style=\"font-style: italic;\">84<\/span> (6) 1341-1351. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1351\/PAC-CON-11-08-22\">10.1351\/PAC-CON-11-08-22<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Enantioselective reduction of \u03b1,\u03b2-enones using an oxazaborolidine catalyst generated in situ from a chiral lactam alcohol<\/span>.<br \/>\nYasuhiro Kawanami, Yudai Mikami, Kazuya Kiguchi, Yuki Harauchi, Ryo C. Yanagita.<br \/>\n<span style=\"font-style: italic;\">Tetrahedron: Asymmetry<\/span>&nbsp;<span style=\"font-weight: bold;\">2011<\/span>, <span style=\"font-style: italic;\">22<\/span> (20\u201422), 1891\u20131894. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.tetasy.2011.10.018\">10.1016\/j.tetasy.2011.10.018<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Generation of \u2018unnatural natural product\u2019 library and identification of a small molecule inhibitor of XIAP<\/span>.<br \/>\nTatsuro Kawamura, Kohei Matsubara, Hitomi Otaka, Etsu Tashiro, Kazutoshi Shindo, Ryo C. Yanagita, Kazuhiro Irie, Masaya Imoto.<br \/>\n<span style=\"font-style: italic;\">Bioorg. Med. Chem<\/span>. <span style=\"font-weight: bold;\">2011<\/span>, <span style=\"font-style: italic;\">19<\/span> (14), 4377\u20134385. [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bmc.2011.05.009\">10.1016\/j.bmc.2011.05.009<\/a>]&nbsp; [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21696964\">21696964<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an antiproliferative analogue of tumor-promoting aplysiatoxin<\/span>.<br \/>\nYu Nakagawa, Masayuki Kikumori, Ryo C. Yanagita, Akira Murakami, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Biosci. Biotechnol. Biochem<\/span>. <span style=\"font-weight: bold;\">2011<\/span>, <span style=\"font-style: italic;\">75<\/span> (6),&nbsp;&nbsp; 1167\u20131173.&nbsp;&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1271\/bbb.110130\">10.1271\/bbb.110130<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21670518\">21670518<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Role of the phenolic hydroxyl Group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity<\/span>.<br \/>\nRyo C. Yanagita, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Yu Nakagawa, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Bioorg. Med. Chem. Lett<\/span>. <span style=\"font-weight: bold;\">2010<\/span>, <span style=\"font-style: italic;\">20<\/span> (20), 6064\u20136066.&nbsp;&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bmcl.2010.08.051\">10.1016\/j.bmcl.2010.08.051<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20817520\">20817520<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-like activity<\/span>.<br \/>\nYu Nakagawa, Ryo C. Yanagita, Naoko Hamada, Akira Murakami, Hideyuki Takahashi, Naoaki Saito, Hiroshi Nagai, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">J. Am. Chem. Soc<\/span>. <span style=\"font-weight: bold;\">2009<\/span>, <span style=\"font-style: italic;\">131<\/span> (22), 7573\u20137579.&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja808447r\">10.1021\/ja808447r<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19449873\">19449873<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes<\/span>.<br \/>\nRyo C. Yanagita, Yu Nakagawa, Nobuhiro Yamanaka, Kaori Kashiwagi, Naoaki Saito, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">J. Med. Chem<\/span>. <span style=\"font-weight: bold;\">2008<\/span>, <span style=\"font-style: italic;\">51<\/span> (1), 46\u201356.&nbsp;&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jm0706719\">10.1021\/jm0706719<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18072722\">18072722<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes<\/span>.<br \/>\nRyo C. Yanagita, Keiji Torii, Yu Nakagawa, Kazuhiro Irie.<br \/>\n<span style=\"font-style: italic;\">Heterocycle<\/span> <span style=\"font-weight: bold;\">2007<\/span>, <span style=\"font-style: italic;\">73<\/span>, 289\u2013302.&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.3987\/COM-07-S(U)3\">10.3987\/COM-07-S(U)3<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C\u03b5 and \u03b7<\/span>.<br \/>\nYu Nakagawa, Kazuhiro Irie, Ryo C. Yanagita, Hajime Ohigashi,Ken-ichiro Tsuda, Kaori Kashiwagi, Naoaki Saito.<br \/>\n<span style=\"font-style: italic;\">J. Med. Chem<\/span>. <span style=\"font-weight: bold;\">2006<\/span>, <span style=\"font-style: italic;\">49<\/span> (4), 2981\u20132688.&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jm050857c\">10.1021\/jm050857c<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16640328\">16640328<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Three genomes differentially contribute to the biosynthesis of benzoxazinones in hexaploid wheat<\/span>.<br \/>\nTaiji Nomura, Atsushi Ishihara, Ryo C. Yanagita, Takashi R. Endo, Hajime Iwamura.<br \/>\n<span style=\"font-style: italic;\">Proc. Natl. Acad. Sci. USA<\/span> <span style=\"font-weight: bold;\">2005<\/span>, <span style=\"font-style: italic;\">102<\/span> (45), 16490\u201316495.&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1073\/pnas.0505156102\">10.1073\/pnas.0505156102<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16260753\">16260753<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Indolactam-V is involved in the CH\/\u03c0 interaction with Pro-11 of the PKC\u03b4 C1B domain: Application for the&nbsp;structural optimization of the PKC\u03b4 ligand<\/span>.<br \/>\nYu Nakagawa, Kazuhiro Irie, Ryo C. Yanagita, Hajime Ohigashi, Ken-ichiro Tsuda.<br \/>\n<span style=\"font-style: italic;\">J. Am. Chem. Soc<\/span>. <span style=\"font-weight: bold;\">2005<\/span>, <span style=\"font-style: italic;\">127<\/span> (16), 5746\u20135747.&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja050447d\">10.1021\/ja050447d<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15839646\">15839646<\/a>]<\/li>\n<\/ol>\n<p class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold; font-style: italic;\">Book Chapters and Reviews<\/span><\/p>\n<ol reversed=\"reversed\">\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin<\/span>.<br \/>\nKazuhiro Irie, Ryo C. Yanagita.<br \/>\n<span style=\"font-style: italic;\">Chem. Rec<\/span>. <span style=\"font-weight: bold;\">2014<\/span>, <span style=\"font-style: italic;\">14<\/span> (2), 251\u2013267.&nbsp;&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/tcr.201300036\">10.1002\/tcr.201300036<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24677503\">24677503<\/a>]<\/li>\n<li class=\"paragraph_style\" style=\"text-align: left;\"><span style=\"font-weight: bold;\">Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism for protein kinase C\u03b4<\/span>.<br \/>\nKazuhiro Irie, Ryo C. Yanagita, Yu Nakagawa.<br \/>\n<span style=\"font-style: italic;\">Med. Res. Rev<\/span>. <span style=\"font-weight: bold;\">2012<\/span>, <span style=\"font-style: italic;\">32<\/span> (3), 518\u2013535.&nbsp; [DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/med.20220\">10.1002\/med.20220<\/a>] [PubMed: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21064191\">21064191<\/a>]<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u65e5\u672c\u8a9e Ryo C. Yanagita, Ph.D. Kag &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_locale":"","_original_post":"","footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry","ja"],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"onepress-blog-small":false,"onepress-small":false,"onepress-medium":false},"uagb_author_info":{"display_name":"RCY","author_link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/author\/charlesy\/"},"uagb_comment_info":0,"uagb_excerpt":"\u65e5\u672c\u8a9e Ryo C. Yanagita, Ph.D. Kag ...","_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":36,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":2806,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages\/8\/revisions\/2806"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}