{"id":80,"date":"2016-10-14T15:32:49","date_gmt":"2016-10-14T06:32:49","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/?page_id=80"},"modified":"2026-06-04T13:44:31","modified_gmt":"2026-06-04T04:44:31","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/publications\/","title":{"rendered":"\u8ad6\u6587"},"content":{"rendered":"\n

Since 2010<\/p>\n\n\n\n

Peer-Reviewed Papers<\/span><\/p>\n\n\n\n

*corresponding author<\/p>\n\n\n\n

    \n
  1. Isolation and characterization of blastmycetin G, a sofa-conformation fixed analog of teleocidin B\u2019s, produced by Streptomyces blastmyceticus<\/em><\/a>.\"\"
    <\/strong>Shin-ichiro Kajiyama*, Ryo C. Yanagita, Chihiro Tsukano, Kazuhiro Irie.
    Biosci. Biotechnol. Biochem.<\/em> 2026<\/strong>, 90<\/em>, 741\u2013745. [DOI:     10.1093\/bbb\/zbag044<\/a>] [Pubmed: 41894235<\/a>]<\/li>\n\n\n\n
  2. Identification of New Cyclocircadins from Cyclocybe erebia<\/em> and Their Effects on the Circadian Rhythm of Human Osteosarcoma Cells<\/a>.
    <\/strong>Kota Seki, Keisuke Kariya, Ryo Miyata, Daisuke Sasaki, Yusei Kobayashi, Kotomi Ueno, Ryo C. Yanagita, Yu Tahara, Yoshihiro Nakajima, Atsushi Ishihara*.
    J. Nat. Prod.<\/em> 2026<\/strong>, 89<\/em>, 421\u2013432. [DOI:     10.1021\/acs.jnatprod.5c01158<\/a>] [Pubmed: 41589635<\/a>]<\/li>\n\n\n\n
  3. Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C<\/a>.\"\"
    <\/strong>Mana Morishita, Kohei Hada, Yusuke Araki, Keisuke Fukaya, Daisuke Urabe, Ryo C. Yanagita, Jumpei Maki, Yusuke Hanaki, Masaki Kita, Kazuhiro Irie, Toshio Nishikawa*.
    Eur. J. Org. Chem.<\/em> 2025<\/strong>, 28<\/em>, e202500890. [DOI:     10.1002\/ejoc.202500890<\/a>]<\/li>\n\n\n\n
  4. Six-step synthesis and epithelial\u2013mesenchymal transition-inhibitory activity of a tetralone-based vitetrifolin analog<\/a>.\"\"
    <\/strong>Yusuke Hanaki*, Yasunori Sugiyama, Ryo C. Yanagita.
    Biosci. Biotechnol. Biochem.<\/em> 2025<\/strong>, 89, 805\u2013810. [DOI:     10.1093\/bbb\/zbaf030<\/a>] [Pubmed: 40058878<\/a>]<\/a><\/li>\n\n\n\n
  5. Validation of Machine Learning-assisted Screening of PKC Ligands: PKC Binding Affinity and Activation<\/a>.
    <\/strong>Jumpei Maki, Asami Oshimura, Yudai Shiotani, Maki Yamanaka, Sogen Okuda, Ryo C. Yanagita, Shigeru Kitani, Yasuhiro Igarashi, Yutaka Saito, Yasubumi Sakakibara, Chihiro Tsukano, Kazuhiro Irie*.
    Biosci. Biotechnol. Biochem.<\/em> 2025<\/strong>, 89, 668\u2013679. [DOI:     10.1093\/bbb\/zbaf008<\/a>] [Pubmed: 39863420<\/a>]<\/li>\n\n\n\n
  6. Identification of sesquiterpene aldehydes as volatile antifungal compounds in Phaeolepiota aurea<\/em> culture filtrate<\/strong><\/a>.
    Kota Seki, Tomoya Tanaka, Emiko Shimoda, Shinji Tanio, Ryo C. Yanagita, Tsugumi Miyazaki, Kento Tokumoto, Toshiaki Tazawa, Kumiko Osaki-Oka, Atsushi Ishihara*.
    Biosci. Biotechnol. Biochem.<\/em> 2024<\/strong>, 88, 1395\u20131402. [DOI:     10.1093\/bbb\/zbae125<\/a>] [Pubmed: 39237456<\/a>]<\/li>\n\n\n\n
  7. Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R<\/em>)-(\u2212)-carvone-based core<\/b><\/a>.
    Ryo C. Yanagita*, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.
    Biosci. Biotechnol. Biochem.<\/i> 2024<\/strong>, 88, 992\u2013998. [DOI:     10.1093\/bbb\/zbae091<\/a>] [Pubmed: 38936828<\/a>]  [Accepted Manuscript<\/strong><\/a><\/span>
    \"\"<\/figure><\/strong><\/a><\/a>]<\/span>
    \"\"<\/figure><\/li>\n\n\n\n
  8. A new labdane-type diterpenoid from leaves of Vitex rotundifolia<\/em><\/strong><\/a>. \"\"
    Yusuke Hanaki*, Rintaro Abe, Yasunori Sugiyama, Yasumasa Hara, Ryo C. Yanagita.
    Results Chem.<\/i> 2024<\/strong>, 7, 101512. [DOI:     10.1016\/j.rechem.2024.101512<\/a>]<\/span><\/li>\n\n\n\n
  9. Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation<\/strong><\/a>.
    Jumpei Maki, Yusuke Hanaki, Ryo C. Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie*.
    Biosci. Biotechnol. Biochem.<\/i> 2023<\/strong>, 87, 1453\u20131461. [DOI:     10.1093\/bbb\/zbad128<\/a>] [Pubmed: 37682524<\/a>]<\/span><\/li>\n\n\n\n
  10. Cell Morphology-Based Screening Identified Vitetrifolin D from Vitex rotundifolia<\/i> as an Inhibitor of Phorbol Ester\u2013Induced Downregulation of E-Cadherin in HHUA Endometrial Cells<\/strong><\/a>. \"\"
    Yusuke Hanaki*, Nichika Iwase, Yasunori Sugiyama, Sena Miyoshi, Ryo C. Yanagita.
    BPB Reports<\/i> 2023<\/strong>, 6, 103\u2013107. [DOI:     10.1248\/bpbreports.6.3_103<\/a>]<\/span><\/li>\n\n\n\n
  11. A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities<\/strong><\/a>.Tomoki Sekido, Kosuke Yamamoto, Ryo C. Yanagita*, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.
    Bioorg. Med. Chem.<\/i> 2022<\/strong>, 73, 116988. [DOI:     10.1016\/j.bmc.2022.116988<\/a>] [Pubmed: 36113282<\/a>]  [Accepted Manuscript<\/strong><\/a><\/span>
    \"\"<\/figure><\/strong><\/a><\/a>]<\/span>
    \"\"<\/figure><\/li>\n\n\n\n
  12. 12-O<\/em>-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial\u2013mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases<\/strong><\/a>.
    Yusuke Hanaki*, Sena Miyoshi, Yasunori Sugiyama, Ryo C. Yanagita, Masashi Sato.
    Biosci. Biotechnol. Biochem.<\/i> 2022<\/strong>, 86, 1417\u20131422. [DOI:     10.1093\/bbb\/zbac136<\/a>] [Pubmed: 35973688<\/a>]<\/span><\/li>\n\n\n\n
  13. Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid \u03b240 Trimer Models<\/a><\/strong>.
    Ayumi Uchino, Yumi Irie, Chihiro Tsukano, Taiji Kawase, Kenji Hirose, Yusuke Kageyama, Ikuo Tooyama, Ryo C. Yanagita, Kazuhiro Irie*.
    ACS Chem. Neurosci.<\/i> 2022<\/strong>, 13, 2517\u20132528. [DOI:     10.1021\/acschemneuro.2c00363<\/a>] [Pubmed: 35930616<\/a>]<\/span><\/li>\n\n\n\n
  14. Structural basis of the 24B3 antibody against the toxic conformer of amyloid \u03b2 with a turn at positions 22 and 23<\/a><\/strong>.
    Yumi Irie, Yuka Matsushima, Akiko Kita, Kunio Miki, Tatsuya Segawa, Masahiro Maeda, Ryo C. Yanagita, Kazuhiro Irie*.
    BIochem. Biophys. Res. Commun.<\/i> 2022<\/strong>, 621, 162\u2013167. [DOI:     10.1016\/j.bbrc.2022.07.010<\/a>] [Pubmed: 35839743<\/a>]<\/span><\/li>\n\n\n\n
  15. Design, synthesis, and biological activity of synthetically-accessible analog of aplysiatoxin with (R<\/em>)-(\u2212)-carvone-based conformation-controlling unit<\/strong><\/a>.
    Yoshiyuki Suzuki, Keiichi Moritoki, Mizuki Kajiwara, Ryo C. Yanagita*, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.
    Biosci. Biotechnol. Biochem.<\/i> 2022<\/strong>, 86, 1013\u20131023. [DOI:     10.1093\/bbb\/zbac084<\/a>] [Pubmed: 35648459<\/a>] <\/span>[Accepted Manuscript<\/strong><\/a>
    \"\"<\/figure><\/strong><\/a><\/strong>]<\/span>
    \"\"<\/figure><\/li>\n\n\n\n
  16. AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity<\/a><\/strong>.
    Jumpei Maki, Asami Oshimura, Chihiro Tsukano, Ryo C. Yanagita, Yutaka Saito, Yasubumi Sakakibara, Kazuhiro Irie*.
    Chem. Commun.<\/i> 2022<\/strong>, 58, 6693\u20136696. [DOI:     10.1039\/D2CC01759H<\/a>] [Pubmed: 35608215<\/a>]<\/span><\/li>\n\n\n\n
  17. Analysis of binding mode of vibsanin A with protein kinase C C1 domains: An experimental and molecular dynamics simulation study<\/strong><\/a>.
    Ryo C. Yanagita*, Mao Otani, Satoshi Hatanaka, Hiroto Nishi, Shota Miyake, Yusuke Hanaki, Masashi Sato, Yasuhiro Kawanami, Kazuhiro Irie.
    J. Mol. Struct.<\/i> 2022<\/strong>, 1260, 132866. [DOI:     10.1016\/j.molstruc.2022.132866<\/a>] [Accepted Manuscript<\/strong><\/a><\/span>
    \"\"<\/figure><\/strong><\/a><\/a>]<\/span>
    \"\"<\/figure><\/li>\n\n\n\n
  18. Structure optimization of the toxic conformation model of amyloid \u03b242 by intramolecular disulfide bond formation<\/strong><\/a>.
    Yuka Matsushima, Yumi Irie, Yusuke Kageyama, Jean-Pierre Bellier, Ikuo Tooyama, Takahito Maki, Toshiaki Kume, Ryo C. Yanagita, Kazuhiro Irie*.
    ChemBioChem<\/i> 2022<\/strong>, 23, e202200029. [DOI:     10.1002\/cbic.202200029<\/a>] [Pubmed: 35165998<\/a>]<\/span><\/li>\n\n\n\n
  19. Evaluation of the in vitro<\/em> cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions<\/a><\/strong>. \"\"
    Yusuke Hanaki*, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita.
    Fundam. Toxicol. Sci<\/em>. 2021<\/strong>, 8, 69\u201373. [DOI:     10.2131\/fts.8.69<\/a>]<\/span><\/li>\n\n\n\n
  20. Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities<\/strong><\/a>.
    Atsuko Gonda, Koji Takada, Ryo C. Yanagita, Shingo Dan, Kazuhiro Irie*.
    Biosci. Biotechnol. Biochem. <\/span>2021<\/span>, 85<\/span>, 168\u2013180. [DOI:     10.1093\/bbb\/zbaa024<\/a>] [Pubmed: 33577665<\/a>]<\/span><\/li>\n\n\n\n
  21. Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH\/\u03c0 interaction<\/strong><\/a>.
    Takumi Kobayashi, Ryo C. Yanagita, Kazuhiro Irie*.
    Bioorg. Med. Chem. Lett.<\/span> 2021<\/span>, 30<\/span>, 127657. [DOI:     10.1016\/j.bmcl.2020.127657<\/a>] [Pubmed: 33130291<\/a>]<\/span><\/li>\n\n\n\n
  22. Evaluation of the Anti-Proliferative Activity of Rare Aldohexoses against MOLT-4F and DU-145 Human Cancer Cell Line and Structure-Activity Relationship of D-Idose.<\/span><\/a> \"\"
    Hironobu Ishiyama, Ryo C. Yanagita*, Kazune Takemoto, Natsumi Kitaguchi, Yuuki Uezato, Yasunori Sugiyama, Masashi Sato, Yasuhiro Kawanami.
    J. Appl. Glycosci.<\/span> 2020<\/span>, 67<\/span>, 95\u2013101. [DOI:     10.5458\/jag.jag.JAG-2020_0006<\/a>] [Pubmed: 34354535<\/a>]<\/span><\/li>\n\n\n\n
  23. Control of the toxic conformation of amyloid \u03b242 by intramolecular disulfide bond formation.<\/span><\/a>
    Yuka Matsushima, Ryo C. Yanagita, Kazuhiro Irie*.
    Chem. Commun.<\/span> 2020<\/span>, 56<\/span>, 4118\u20134121. [DOI:     10.1039\/D0CC01053G<\/a>] [Pubmed: 32163091<\/a>]<\/span><\/li>\n\n\n\n
  24. Nematocidal Activity of 6-O<\/span>-octanoyl- And 6-O<\/span>-octyl-D-allose Against Larvae of Caenorhabditis elegans<\/span>.<\/span><\/span><\/a>
    Hirofumi Sakoguchi, Tomoya Shintani, Hironobu Ishiyama, Ryo C. Yanagita, Yasuhiro Kawanami, Masashi Sato*.
    Biosci. Biotechnol. Biochem.<\/span> 2019<\/span>, 83<\/span> (12), 2194\u20132197. [DOI:     10.1080\/09168451.2019.1648206<\/a>] [Pubmed: 31357905<\/a>]<\/span><\/li>\n\n\n\n
  25. Synthesis, Conformation, and Biological Activities of a Des-A-Ring Analog of 18-Deoxy-aplog-1, a Simplified Analog of Debromoaplysiatoxin.<\/span><\/a>
    Yoshiki Ashida, Ryo C. Yanagita*, Yasuhiro Kawanami, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie.
    Heterocycles<\/span> 2019<\/span>, 99<\/span> (2), 942\u2013957. [DOI:     10.3987\/COM-18-S(F)60<\/a>] <\/span>[CLOCKSS\"\"<\/a>] [Accepted Manuscript<\/strong><\/a><\/span>
    \"\"<\/figure><\/strong><\/a><\/a>] [SI<\/strong><\/a>
    \"\"<\/figure><\/strong><\/a>]<\/span>
    \"\"<\/figure><\/li>\n\n\n\n
  26. Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid \u03b240 with a toxic conformation.<\/span><\/a>
    Yumi Irie, Mizuho Hanaki, Kazuma Murakami, Tsuneo Imamoto, Takumi Furuta, Takeo Kawabata, Taiji Kawase, Kenji Hirose, Yoko Monobe, Ken-ichi Akagi, Ryo C. Yanagita, Kazuhiro Irie*.
    Chem. Commun.<\/span> 2019<\/span>, 55<\/span> (2), 182\u2013185. [DOI:     10.1039\/C8CC08618D<\/a>] <\/span> [Pubmed: 30519688<\/a>]<\/li>\n\n\n\n
  27. Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, a Potential Anti-Cancer Lead Derived from Debromoaplysiatoxin<\/a>.<\/span>
    Koutaro Hayakawa, Yusuke Hanaki, Harukuni Tokuda, Ryo C. Yanagita, Yu Nakagawa, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie*.
    Heterocycles<\/span> 2018<\/span>, 97<\/span> (1), 478\u2013492. [DOI:     10.3987\/COM-18-S(T)37<\/a>] <\/span>[CLOCKSS\"\"<\/a>] [Accepted Manuscript<\/strong><\/a><\/span>
    \"\"<\/figure><\/strong><\/a><\/a>] [SI<\/strong><\/a>
    \"\"<\/figure><\/strong><\/a>]<\/span><\/li>\n\n\n\n
  28. Synthesis and inhibitory activity of deoxy-D<\/span>-allose amide derivative against plant growth.<\/span><\/a>
    Md. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami*.
    Biosci. Biotechnol. Biochem.<\/span> 2018<\/span>, 82<\/span> (5), 775\u2013779. [DOI:     10.1080\/09168451.2018.1445521<\/a>] [Pubmed: 29513080<\/a>] <\/span><\/li>\n\n\n\n
  29. Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.<\/span>\"\"<\/a>
    Yusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie*.
    Molecules<\/span> 2017<\/span>, 22<\/span> (4), E631. [DOI:     10.3390\/molecules22040631<\/a>] [Pubmed: 28406454<\/a>] <\/span><\/li>\n\n\n\n
  30. Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure\u2013activity study on simplified analogs of the receptor-recognition domain<\/span><\/a>.
    Yoshiki Ashida, Ryo C. Yanagita*, Chise Takahashi, Yasuhiro Kawanami, Kazuhiro Irie.
    Bioorg. Med. Chem<\/span>. 2016<\/span>, 24<\/span> (18), 4218-4227. [DOI:     10.1016\/j.bmc.2016.07.011<\/a>] [Pubmed: 27436807<\/a>] [Accepted Manuscript<\/strong><\/a><\/span>
    \"\"<\/figure><\/strong><\/a><\/a>]
    \"1-s2-0-s096808961630503x-fx1\"<\/figure><\/span><\/li>\n\n\n\n
  31. Syntheses and biological activities of deoxy-D<\/span>-allose fatty acid ester analogs<\/span><\/a>.
    Md. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami*.
    Biosci. Biotechnol. Biochem<\/span>. 2016<\/span>, 80<\/span> (4), 676-681. [DOI:     10.1080\/09168451.2015.1132151<\/a>] [Pubmed: 26822163<\/a>]<\/span><\/li>\n\n\n\n
  32. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead<\/span><\/a>.
    Masayuki Kikumori, Ryo C. Yanagita, Harukuni Tokuda, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie*.
    Biosci. Biotechnol. Biochem<\/span>. 2016<\/span>, 80<\/span> (2) 221-231. [DOI:     10.1080\/09168451.2015.1091718<\/a>] [Pubmed: 26452398<\/a>]<\/span><\/li>\n\n\n\n
  33. Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities<\/span><\/a>.
    Yusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*.
    Biosci. Biotechnol. Biochem<\/span>. 2015<\/span>, 79<\/span> (6) 888-895. [DOI:     10.1080\/09168451.2014.1002452<\/a>] [Pubmed: 25612633<\/a>]<\/span><\/li>\n\n\n\n
  34. Effect of BF3<\/sub> on the enantioselective reduction of trifluoromethyl ketones using a chiral lactam alcohol with borane<\/span><\/a>.
    Yuki Harauchi, Chihiro Takakura, Toshio Furumoto, Ryo C. Yanagita, Yasuhiro Kawanami*.
    Tetrahedron: Asymmetry <\/span>2015<\/span>, 26<\/span> (7) 333-337. [DOI:     10.1016\/j.tetasy.2015.02.011<\/a>]<\/span><\/li>\n\n\n\n
  35. Synthesis of 6-O<\/span>-decanoyl-D<\/span>-altrose and 6-O<\/span>-decanoyl-D<\/span>-gulose and evaluation of their biological activity on plant growth<\/span><\/a>.
    Md. Tazul Islam Chowdhury, Madoka Naito, Ryo C. Yanagita, Yaushiro Kawanami*.
    Plant Growth Regul<\/span>. 2015<\/span>, 75<\/span> (3) 707-713. [DOI:     10.1007\/s10725-014-9972-2<\/a>]<\/span><\/li>\n\n\n\n
  36. Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug<\/span><\/a>.
    Masayuki Kikumori, Ryo C. Yanagita, Kazuhiro Irie*.
    Tetrahedron<\/span> 2014<\/span>, 70<\/span> (52) 9776-9782. [DOI:     10.1016\/j.tet.2014.11.026<\/a>]<\/span><\/li>\n\n\n\n
  37. Anti-proliferative activity of 6-O<\/span>-acyl-D<\/span>-allose against the human leukemia MOLT-4F cell line<\/span><\/a>.
    Ryo C. Yanagita*, Katsuya Kobashi, Chisa Ogawa, Yoshiki Ashida, Haruka Yamaashi, Yasuhiro Kawanami.
    Biosci. Biotechnol. Biochem<\/span>. 2014<\/span>,  78<\/span> (2) 190-194. [DOI:     10.1080\/09168451.2014.882747<\/a>] [Pubmed: 25036670<\/a>]<\/span>
    \"allose1\"<\/figure><\/li>\n\n\n\n
  38. Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction<\/span><\/a>.
    Yuming Wang, Jiahui Wang, Ryo C. Yanagita, Chunhua Liu, Xiaoqian Hu, Ping Dong, Changhu Xue*, Yong Xue*.
    Biosci. Biotechnol. Biochem<\/span>. 2014<\/span>, 78<\/span> (1) 139-146. [DOI:     10.1080\/09168451.2014.877830<\/a>] [Pubmed: 25036496<\/a>]<\/span><\/li>\n\n\n\n
  39. Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities<\/span><\/a>.
    Ryo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie*.
    Bioorg. Med. Chem. Lett<\/span>. 2013<\/span>, 23<\/span> (15) 4319-4323. [DOI:     10.1016\/j.bmcl.2013.05.096<\/a>] [Pubmed: 23803585<\/a>]<\/span>
    \"1-s2-0-s0960894x13007026-fx1\"<\/figure><\/li>\n\n\n\n
  40. Structure\u2013activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity<\/span><\/a>.
    Hiroaki Kamachi, Keisuke Tanaka, Ryo C. Yanagita, Akira Murakami, Kazuma Murakami, Harukuni Tokuda, Nobutaka Suzuki, Yu Nakagawa, Kazuhiro Irie*.
    Bioorg. Med. Chem<\/span>. 2013<\/span>, 21<\/span> (10) 2695-2702. [DOI:     10.1016\/j.bmc.2013.03.013<\/a>] [Pubmed: 23582444<\/a>]<\/span><\/li>\n\n\n\n
  41. Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures<\/span>.<\/a>
    Yuki Shu, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*.
    Heterocycles<\/span> 2012<\/span>, 8<\/span>6 (1) 281-303. [DOI:     10.3987\/COM-12-S(N)8<\/a><\/span>] <\/span>[CLOCKSS\"\"<\/a>] [Accepted Manuscript<\/strong><\/a><\/span>
    \"\"<\/figure><\/strong><\/a><\/a>]<\/span><\/li>\n\n\n\n
  42. Identification and biolofical activities of bryostatins from Japanese bryozoan<\/span><\/a>.
    Sayo Ueno. Ryo C. Yanagita, Kazuma Murakami, Akira Murakami, Harukuni Tokuda, Nobutaka Suzuki, Takeshi Fujiwara, Kazuhiro Irie*.
    Biosci. Biotechnol. Biochem<\/span>. 2012<\/span>, 76<\/span> (5) 1041-1043. [DOI:     10.1271\/bbb.120026<\/a>] [Pubmed: 22738985<\/a>]<\/span><\/li>\n\n\n\n
  43. Structure\u2013activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activit<\/span>y<\/a>.
    Masayuki Kikumori. Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Kazuhiro Irie*.
    J. Med. Chem<\/span>. 2012<\/span>, 55<\/span> (11) 5614-5626. [DOI:     10.1021\/jm300566h<\/a>] [Pubmed: 22625994<\/a>]<\/span><\/li>\n\n\n\n
  44. Synthesis and structure\u2013activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1<\/span><\/a>.
    Kazuhiro Irie*, Masayuki Kikumori, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Yu Nakagawa.
    Pure Appl. Chem<\/span>. 2012<\/span>, 84<\/span> (6) 1341-1351. [DOI:     10.1351\/PAC-CON-11-08-22<\/a>]<\/span><\/li>\n\n\n\n
  45. Enantioselective reduction of \u03b1,\u03b2-enones using an oxazaborolidine catalyst generated in situ from a chiral lactam alcohol<\/span><\/a>.
    Yasuhiro Kawanami*, Yudai Mikami, Kazuya Kiguchi, Yuki Harauchi, Ryo C. Yanagita.
    Tetrahedron: Asymmetry<\/span> 2011<\/span>, 22<\/span> (20\u201422), 1891\u20131894. [DOI:     10.1016\/j.tetasy.2011.10.018<\/a>]<\/span><\/li>\n\n\n\n
  46. Generation of \u2018unnatural natural product\u2019 library and identification of a small molecule inhibitor of XIAP<\/span><\/a>.
    Tatsuro Kawamura, Kohei Matsubara, Hitomi Otaka, Etsu Tashiro, Kazutoshi Shindo, Ryo C. Yanagita, Kazuhiro Irie, Masaya Imoto*.
    Bioorg. Med. Chem<\/span>. 2011<\/span>, 19<\/span> (14), 4377\u20134385. [DOI:     10.1016\/j.bmc.2011.05.009<\/a>]  [PubMed: 21696964<\/a>]<\/span><\/li>\n\n\n\n
  47. Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin<\/span><\/a>.
    Yu Nakagawa, Masayuki Kikumori, Ryo C. Yanagita, Akira Murakami, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie*.
    Biosci. Biotechnol. Biochem<\/span>. 2011<\/span>, 75<\/span> (6),   1167\u20131173.   [DOI:     10.1271\/bbb.110130<\/a>] [PubMed: 21670518<\/a>]<\/span><\/li>\n\n\n\n
  48. Role of the phenolic hydroxyl Group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity<\/span><\/a>.
    Ryo C. Yanagita, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Yu Nakagawa, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie*.
    Bioorg. Med. Chem. Lett<\/span>. 2010<\/span>, 20<\/span> (20), 6064\u20136066.   [DOI:     10.1016\/j.bmcl.2010.08.051<\/a>] [PubMed: 20817520<\/a>]<\/span>
    \"1-s2-0-s0960894x10011741-fx1\"<\/figure><\/li>\n<\/ol>\n\n\n\n

    Non-Peer-Reviewed Papers<\/span><\/p>\n\n\n\n

      \n
    1. Inhibitory activity of 6-O<\/em>-decyl-D-allose and 6-(decanoylamino)-6-deoxy-D-allose against plant growth<\/span><\/a>.
      Haruka Yamaashi, Md. Tazul Islam Chowdhury, Ryo C. Yanagita, Yasuhiro Kawanami.
      Tech. Bull. Fac. Agr. Kagawa Univ. <\/em>2017<\/span>, 69<\/i> (122), 17\u201322.<\/li>\n<\/ol>\n\n\n\n

      Book Chapters and Reviews<\/span><\/p>\n\n\n\n

        \n
      1. Practical Enantioselective Reduction of Ketones Using Oxazaborolidine Catalysts Generated In Situ from Chiral Lactam Alcohols.<\/span>\"\"<\/a>
        Yasuhiro Kawanami*, Ryo C. Yanagita.
        Molecules<\/span> 2018<\/span>, 23<\/span> (10), E2408. [DOI:         10.3390\/molecules23102408<\/a>] [Pubmed: 30241305<\/a>] <\/span><\/li>\n\n\n\n
      2. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin<\/span><\/a>.
        Kazuhiro Irie*, Ryo C. Yanagita.
        Chem. Rec<\/span>. 2014<\/span>, 14<\/span> (2), 251\u2013267.   [DOI:         10.1002\/tcr.201300036<\/a>] [PubMed: 24677503<\/a>]<\/span><\/li>\n\n\n\n
      3. Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism for protein kinase C\u03b4<\/span><\/a>.
        Kazuhiro Irie*, Ryo C. Yanagita, Yu Nakagawa.
        Med. Res. Rev<\/span>. 2012<\/span>, 32<\/span> (3), 518\u2013535.  [DOI:         10.1002\/med.20220<\/a>] [PubMed: 21064191<\/a>]<\/span><\/li>\n<\/ol>\n\n\n\n

        Archives for pre-2009 papers<\/p>\n\n\n\n

        Peer-Reviewed Papers<\/span><\/p>\n\n\n\n

        *corresponding author<\/p>\n\n\n\n

          \n
        1. Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes<\/span><\/a>.
          Ryo C. Yanagita, Keiji Torii, Yu Nakagawa, Kazuhiro Irie*.
          Heterocycles<\/i> 2007<\/span>, 73<\/span> (1), 289\u2013302.  [DOI:           10.3987\/COM-07-S(U)3<\/a>]<\/span> [CLOCKSS\"\"<\/a>] [Accepted Manuscript<\/strong><\/a><\/span>
          \"\"<\/figure><\/strong><\/a><\/a>]<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

          Since 2010 Peer-Reviewed Paper …<\/p>\n","protected":false},"author":1,"featured_media":485,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_locale":"ja","_original_post":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/?page_id=80","footnotes":""},"class_list":["post-80","page","type-page","status-publish","has-post-thumbnail","hentry","ja"],"aioseo_notices":[],"uagb_featured_image_src":{"full":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications.png",1420,550,false],"thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications-150x150.png",150,150,true],"medium":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications-300x116.png",300,116,true],"medium_large":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications-768x297.png",768,297,true],"large":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications-1024x397.png",800,310,true],"1536x1536":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications.png",1420,550,false],"2048x2048":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications.png",1420,550,false],"onepress-blog-small":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications.png",300,116,false],"onepress-small":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications.png",480,186,false],"onepress-medium":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2016\/10\/publications.png",640,248,false]},"uagb_author_info":{"display_name":"RCY","author_link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/author\/charlesy\/"},"uagb_comment_info":0,"uagb_excerpt":"Since 2010 Peer-Reviewed Paper ...","_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages\/80","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/comments?post=80"}],"version-history":[{"count":126,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages\/80\/revisions"}],"predecessor-version":[{"id":7064,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/pages\/80\/revisions\/7064"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/media\/485"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/media?parent=80"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}