{"id":2558,"date":"2021-02-12T11:56:47","date_gmt":"2021-02-12T02:56:47","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/?p=2558"},"modified":"2025-06-18T17:26:13","modified_gmt":"2025-06-18T08:26:13","slug":"%e3%83%88%e3%83%aa%e3%83%81%e3%82%a6%e3%83%a0%e6%a8%99%e8%ad%98%e5%8c%96%e5%90%88%e7%89%a9%e3%81%ae%e6%b8%9b%e8%a1%b0%e3%81%a8%e6%af%94%e6%b4%bb%e6%80%a7%e3%81%ae%e5%a4%89%e5%8c%96%e3%81%ae%e8%a8%88","status":"publish","type":"post","link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/2021\/02\/12\/%e3%83%88%e3%83%aa%e3%83%81%e3%82%a6%e3%83%a0%e6%a8%99%e8%ad%98%e5%8c%96%e5%90%88%e7%89%a9%e3%81%ae%e6%b8%9b%e8%a1%b0%e3%81%a8%e6%af%94%e6%b4%bb%e6%80%a7%e3%81%ae%e5%a4%89%e5%8c%96%e3%81%ae%e8%a8%88\/","title":{"rendered":"\u30c8\u30ea\u30c1\u30a6\u30e0\u6a19\u8b58\u5316\u5408\u7269\u306e\u6e1b\u8870\u3068\u6bd4\u6d3b\u6027\u306e\u5909\u5316\u306e\u8a08\u7b97"},"content":{"rendered":"\n\n

\u7814\u7a76\u5ba4\u7528\u30e1\u30e2<\/p>\n

\u95a2\u9023\u8a18\u4e8b: \u7d50\u5408\u963b\u5bb3\u5b9a\u6570Ki\u306e\u8a08\u7b97\u5f0f\u306b\u3064\u3044\u3066<\/a><\/p>\n

\u30c8\u30ea\u30c1\u30a6\u30e0 3<\/sup>H \u306e\u534a\u6e1b\u671f\u306f12.32 years\u30021\u5e74\u3092\u5206\u3067\u8868\u308f\u3059\u3068525,600<\/a>\u5206\uff08365\u65e5\u3067\u8a08\u7b97\uff09\u3002\u79d2\u3067\u8868\u308f\u3059\u306831,556,736\u79d2\uff08365.24\u65e5\u3067\u8a08\u7b97\uff09\u300212.32\u5e74\u306f388,778,987\u79d2\u3002<\/span><\/p>\n

\u6642\u9593 t<\/em> = 0\u306e\u6642\u306e\u539f\u5b50\u6570\u3092N<\/em>0<\/sub>\u3068\u3059\u308b\u30681\u79d2\u5f8c\u306e\u539f\u5b50\u6570N<\/em>\u306f<\/p>\n

\\[ N = N_0 \\left(\\frac{1}{2}\\right)^\\frac{1}{388778987} \\] 1\u79d2\u9593\u306b\u5d29\u58ca\u3057\u305f\u539f\u5b50\u6570N’ (Bq) \u306f \\[ N’ = N_0 \\times \\left(1 – \\left(\\frac{1}{2}\\right)^\\frac{1}{388778987}\\right) \\] N<\/em>0<\/sub>\u306b\u30a2\u30dc\u30ac\u30c9\u30ed\u5b9a\u65706.02214 \u00d7 1023<\/sup> mol\u22121<\/sup>\u3092\u4ee3\u5165\u3059\u308b\u3002 \\[ N’ = 6.02214 \\times 10^{23} \\times \\left(1 – \\left(\\frac{1}{2}\\right)^\\frac{1}{388778987}\\right) \\simeq 1.07367685 \\times 10^{15} \\mathrm{Bq\\,\\, mol}^{-1} \\] 1 Ci = 3.7 \u00d7 1010<\/sup> Bq\u306a\u306e\u3067\u3001 \\[ 1.07367685 \\times 10^{15}\\,\\,\\mathrm{Bq\\,\\, mol}^{-1} \\simeq 2901.829 \\,\\,\\mathrm{Ci\\,\\, mol}^{-1} \\simeq 29.02 \\,\\,\\mathrm{Ci\\,\\, mmol}^{-1} \\]\n

3<\/sup>H\u304c\u5d29\u58ca\u3057\u305f\u5f8c\u3001\u6a19\u8b58\u5316\u5408\u7269\u306f\u6d3b\u6027\u304c\u5168\u304f\u306a\u304f\u306a\u308b\u3068\u4eee\u5b9a\u3059\u308b\u3002<\/p>\n

\u8cfc\u5165\u3057\u305f [3<\/sup>H]PDBu \u306e\u6bd4\u6d3b\u6027\u304c 17.16 Ci mmol-1<\/sup>\u3060\u3063\u305f\u306e\u3067\u3001\u3053\u306e\u8a66\u6599\u306f\u6a19\u8b58\u3055\u308c\u305f\u5316\u5408\u7269\u304c59.13%\u3001\u975e\u6a19\u8b58\u5316\u5408\u7269\u304c40.87%\u542b\u307e\u308c\u3066\u3044\u308b\u3002 \u6bd4\u6d3b\u6027\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3057\u3066\u3044\u304f\u304b\u8a08\u7b97\u3057\u3066\u307f\u305f\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
year<\/td>\n% remained<\/td>\nlabelled\/unlabelled<\/td>\n\u6bd4\u6d3b\u6027 (Ci mmol\u22121<\/sup>)<\/td>\n\u30e2\u30eb\u6fc3\u5ea6 (\u03bcM)<\/td>\n<\/tr>\n
0 (2013)<\/td>\n100.00%<\/td>\n59.13 : 40.87<\/td>\n17.16<\/td>\n5.300<\/td>\n<\/tr>\n
1 (2014)<\/td>\n94.53%<\/td>\n55.90 : 40.87<\/td>\n16.76<\/td>\n5.129<\/td>\n<\/tr>\n
2 (2015)<\/td>\n89.36%<\/td>\n52.84 : 40.87<\/td>\n16.36<\/td>\n4.966<\/td>\n<\/tr>\n
3 (2016)<\/td>\n84.47%<\/td>\n49.95 : 40.87<\/td>\n15.96<\/td>\n4.813<\/td>\n<\/tr>\n
4 (2017)<\/td>\n79.85%<\/td>\n47.21 : 40.87<\/td>\n15.56<\/td>\n4.668<\/td>\n<\/tr>\n
5 (2018)<\/td>\n75.48%<\/td>\n44.63 : 40.87<\/td>\n15.15<\/td>\n4.532<\/td>\n<\/tr>\n
6 (2019)<\/td>\n71.35%<\/td>\n42.19 : 40.87<\/td>\n14.74<\/td>\n4.402<\/td>\n<\/tr>\n
7 (2020)<\/td>\n67.45%<\/td>\n39.88 : 40.87<\/td>\n14.33<\/td>\n4.280<\/td>\n<\/tr>\n
8 (2021)<\/td>\n63.76%<\/td>\n37.70 : 40.87<\/td>\n13.92<\/td>\n4.164<\/td>\n<\/tr>\n
9 (2022)<\/td>\n60.27%<\/td>\n35.64 : 40.87<\/td>\n13.52<\/td>\n4.055<\/td>\n<\/tr>\n
10 (2023)<\/td>\n56.97%<\/td>\n33.69 : 40.87<\/td>\n13.11<\/td>\n3.952<\/td>\n<\/tr>\n
11 (2024)<\/td>\n53.85%<\/td>\n31.84 : 40.87<\/td>\n12.71<\/td>\n3.854<\/td>\n<\/tr>\n
12 (2025)<\/td>\n50.91%<\/td>\n30.10 : 40.87<\/td>\n12.31<\/td>\n3.762<\/td>\n<\/tr>\n
13 (2026)<\/td>\n48.12%<\/td>\n28.46 : 40.87<\/td>\n11.91<\/td>\n3.672<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u304a\u307e\u3051: \u653e\u5c04\u6027\u540c\u4f4d\u4f53\u6a19\u8b58\u5316\u5408\u7269\u304c\u5d29\u58ca\u5f8c\u306b\u3069\u306e\u3088\u3046\u306b\u306a\u308b\u304b\u8abf\u3079\u3066\u307f\u305f\u304c\u3088\u304f\u5206\u304b\u3089\u306a\u304b\u3063\u305f\u3002\u967d\u96fb\u5b50\u3092\u653e\u51fa\u3059\u308bfluorodeoxyglucose (18<\/sup>F) \u306e\u5834\u5408\u306f\u81ea\u5df1\u653e\u5c04\u5206\u89e3 (autoradiolysis) \u306b\u3088\u3063\u3066glucuronic acid\u3001arabinoic acid\u3001araburonic acid\u3001gluconic acid\u3001arabinose\u3068\u3044\u3063\u305f\u9178\u5316\u751f\u6210\u7269\u304c\u5f62\u6210\u3055\u308c\u308b\u3089\u3057\u30441)<\/sup>\u3002[3<\/sup>H]PDBu\u306e\u03b2\u5d29\u58ca\u5f8c\u306e\u5909\u5316\u306e\u4e88\u60f3\u56f3\u3092\u4e0b\u306e\u3088\u3046\u306b\u66f8\u3044\u3066\u307f\u305f\u304c\u3001\u3042\u304f\u307e\u3067\u4e88\u60f3\u3002<\/p>\n

\"\"<\/p>\n

1) B\u00fariov\u00e1, E., Mac\u00e1\u0161ek, F., Melichar, F. et al.<\/i> Autoradiolysis of the 2-deoxy-2-[18<\/sup>F]fluoro-D-glucose radiopharmaceutical. J. Radioanal. Nucl. Chem. <\/i>2005<\/strong>, 264<\/em>, 595\u2013602. https:\/\/doi.org\/10.1007\/s10967-005-0759-9<\/a><\/p>\n

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