{"id":2730,"date":"2021-07-29T14:04:15","date_gmt":"2021-07-29T05:04:15","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/?p=2730"},"modified":"2021-08-04T00:56:27","modified_gmt":"2021-08-03T15:56:27","slug":"alphafold2","status":"publish","type":"post","link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/2021\/07\/29\/alphafold2\/","title":{"rendered":"AlphaFold2"},"content":{"rendered":"<h2>AlphaFold2<\/h2>\n<p>Alphabet Inc. \u5098\u4e0b\u306eDeepMind\u304c\u958b\u767a\u3057\u3001\u5727\u5012\u7684\u306a\u6027\u80fd\u3092\u898b\u305b\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7acb\u4f53\u69cb\u9020\u4e88\u6e2c\u30d7\u30ed\u30b0\u30e9\u30e0AlphaFold2\u304c\u516c\u958b\u3055\u308cSNS\u3067\u3082\u5927\u76db\u308a\u4e0a\u304c\u308a\u3067\u3057\u305f\u3002<\/p>\n<ul>\n<li><a href=\"https:\/\/www.itmedia.co.jp\/news\/articles\/2107\/20\/news136.html\">\u300c6\u5e74\u89e3\u3051\u306a\u304b\u3063\u305f\u69cb\u9020\u304c\u3042\u3063\u3055\u308a\u300d\u2500\u2500\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u201c\u5f62\u201d\u3092\u4e88\u6e2c\u3059\u308b\u300cAlphaFold2\u300d\u306e\u885d\u6483\u3000GitHub\u3067\u516c\u958b\u3001\u8ab0\u3067\u3082\u5229\u7528\u53ef\u80fd\u306b\uff08ITmedia NEWS\u30012021\u5e747\u670820\u65e5\uff09<\/a><\/li>\n<\/ul>\n<p>\u4e3b\u306a\u751f\u7269\u306e\u5168\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e88\u6e2c\u7acb\u4f53\u69cb\u9020\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3082\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<ul>\n<li data-tadv-p=\"keep\"><a href=\"https:\/\/alphafold.ebi.ac.uk\/\">https:\/\/alphafold.ebi.ac.uk\/<\/a><\/li>\n<\/ul>\n<p>\u30ed\u30fc\u30ab\u30eb\u74b0\u5883\u3078\u306e\u30a4\u30f3\u30b9\u30c8\u30fc\u30eb\uff08<a href=\"https:\/\/qiita.com\/Ag_smith\/items\/7c76438906b3f665af38\">AlphaFold (ver.2) \u30a4\u30f3\u30b9\u30c8\u30fc\u30eb@Ag_smith<\/a>\uff09\u306f\u30c7\u30a3\u30b9\u30af\u5bb9\u91cf\u306a\u3069\u5927\u5909\u305d\u3046\u3067\u3059\u304c\u3001Google Colaboratory\u304b\u3089\u6709\u5fd7\u304c\u516c\u958b\u3057\u305f\u7c21\u6613\u7248\u304c\u5229\u7528\u53ef\u80fd\u3067\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u306a\u3044\u914d\u5217\u3001\u30aa\u30ea\u30b4\u30de\u30fc\u3001\u30d8\u30c6\u30ed\u8907\u5408\u4f53\u306a\u3069\u306e\u69cb\u9020\u4e88\u6e2c\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<ul>\n<li><a href=\"https:\/\/colab.research.google.com\/github\/sokrypton\/ColabFold\/blob\/main\/AlphaFold2.ipynb\">https:\/\/colab.research.google.com\/github\/sokrypton\/ColabFold\/blob\/main\/AlphaFold2.ipynb<\/a><\/li>\n<\/ul>\n\n\n<h2>Protein kinase C\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3069\u3046\u306a\u3063\u3066\u3044\u308b\u304b<\/h2>\n<p>\u305d\u3053\u3067\u3001protein kinase C\u30d5\u30a1\u30df\u30ea\u30fc\u3001C1\u30c9\u30e1\u30a4\u30f3\u3092\u542b\u3080\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e88\u6e2c\u69cb\u9020\u3092\u898b\u3066\u307f\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n<ul>\n<li>PKC\u03b1 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P17252\">https:\/\/alphafold.ebi.ac.uk\/entry\/P17252<\/a><\/li>\n<li>PKC\u03b2 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P05771\">https:\/\/alphafold.ebi.ac.uk\/entry\/P05771<\/a><\/li>\n<li>PKC\u03b3 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P05129\">https:\/\/alphafold.ebi.ac.uk\/entry\/P05129<\/a><\/li>\n<li>PKC\u03b4 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q05655\">https:\/\/alphafold.ebi.ac.uk\/entry\/Q05655<\/a><\/li>\n<li>PKC\u03b5 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q02156\">https:\/\/alphafold.ebi.ac.uk\/entry\/Q02156<\/a><\/li>\n<li>PKC\u03b7 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P24723\">https:\/\/alphafold.ebi.ac.uk\/entry\/P24723<\/a><\/li>\n<li>PKC\u03b8 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q04759\">https:\/\/alphafold.ebi.ac.uk\/entry\/Q04759<\/a><\/li>\n<li>PKC\u03b6 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q05513\">https:\/\/alphafold.ebi.ac.uk\/entry\/Q05513<\/a><\/li>\n<li>PKC\u03b9 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P41743\">https:\/\/alphafold.ebi.ac.uk\/entry\/P41743<\/a><\/li>\n<\/ul>\n<p>\u30c9\u30e1\u30a4\u30f3\u5358\u4f4d\u3067\u306fX\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u3067\u69cb\u9020\u304c\u3044\u304f\u3064\u3082\u89e3\u304b\u308c\u3066\u3044\u3066\u3001\u76f8\u540c\u6027\u3082\u9ad8\u3044\u306e\u3067\u3001\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u3092\u4f7f\u3063\u305f\u30db\u30e2\u30ed\u30b8\u30fc\u30e2\u30c7\u30ea\u30f3\u30b0\u304c\u6709\u52b9\u3067\u3001AlphaFold2\u3067\u3082\u5b9f\u969b\u305d\u3046\u3057\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>Predicted aligned error\u304c\u4f4e\u3044\u9818\u57df\u3067\u793a\u3055\u308c\u308b\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u30c9\u30e1\u30a4\u30f3\u9593\u914d\u7f6e\u3092\u63a2\u3059\u3068\u8208\u5473\u6df1\u304b\u3063\u305f\u306e\u306f\u3001<\/p>\n<ul>\n<li>\u9023\u7d9a\u3057\u305fC1A\u30c9\u30e1\u30a4\u30f3\u3068C1B\u30c9\u30e1\u30a4\u30f3\u304c\u3069\u308c\u3082\u540c\u3058\u3088\u3046\u306a\u914d\u7f6e\u3067\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u308b\u3001\u304b\u3064\u305d\u306e\u30c9\u30e1\u30a4\u30f3\u9593\u76f8\u4e92\u4f5c\u7528\u304c\u4fe1\u983c\u6027\u304c\u9ad8\u3044\u3068\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u8a55\u4fa1\u3057\u3066\u3044\u305f\u70b9\uff08predicted aligned error\u3092\u30d7\u30ed\u30c3\u30c8\u3057\u305f\u56f3\u4e0a\u3067\u7dd1\u8272\u306e\u30af\u30ed\u30b9\u30d4\u30fc\u30af\u304c\u51fa\u308b; Google Colaboratory\u7248\u3067\u306f\u9752\u8272\uff09\u3002<\/li>\n<li><a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P05129\">PKC\u03b3<\/a>\u3068<a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q04759\">PKC\u03b8<\/a>\u3067\u306f\u3001\u507d\u57fa\u8cea (pseudosubstrate) \u914d\u5217\uff08\u03b1\/\u03b2\/\u03b3\u3067\u306fRKGALR; \u03b4\/\u03b8, RRGAIK; \u03b5, RQGAVR; \u03b7, RQRAMR; \u03b6\/\u03b9, RRGARR\uff09 (Gong, <em>et al.<\/em>, 2016) \u304c\u89e6\u5a92\u30c9\u30e1\u30a4\u30f3\u306b\u304d\u3061\u3093\u3068\u84cb\u3092\u3057\u3066\u3044\u308b\u69cb\u9020\u304c\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002<a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q04759\">PKC\u03b8<\/a>\u3067\u306f\u30c9\u30e1\u30a4\u30f3\u9593\u914d\u7f6e\u306e\u4fe1\u983c\u6027\u3092\u793a\u3059predicted aligned error\u306e\u5024\u3082\u3061\u3083\u3093\u3068\u4f4e\u3044\uff08\u7dd1\u8272\uff09\u3002<\/li>\n<li><a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P05129\">PKC\u03b3<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q02156\">\u03b5<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P24723\">\u03b7<\/a>\u3067\u306fC1A+C1B\u3068C2\/C2-like\u30c9\u30e1\u30a4\u30f3\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u4fe1\u983c\u6027\u304c\u9ad8\u3044\u3002<\/li>\n<li>PKC<a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q05513\">\u03b6<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P41743\">\u03b9<\/a>\u306eC1\u30c9\u30e1\u30a4\u30f3\u306f\u9593\u306b\u03b2\u30b9\u30c8\u30e9\u30f3\u30c9\u30921\u672c\u631f\u3093\u3067N\u672b\u7aef\u306ePH\u30c9\u30e1\u30a4\u30f3\u3068\u9006\u5e73\u884c\u03b2\u30b7\u30fc\u30c8\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<p>\u3057\u304b\u3057\u5b9f\u9a13\u7684\u306b\u89e3\u304b\u308c\u305fPKC\u03b2\u306e\u307b\u307c\u5168\u9577\u69cb\u9020\u4e2d\u306eC1B\u30c9\u30e1\u30a4\u30f3\u3068\u89e6\u5a92\u30c9\u30e1\u30a4\u30f3\u306e\u914d\u7f6e\u304c\u771f\u3060\u3068\u3057\u3066\u3001\u305d\u306eC1B\u30c9\u30e1\u30a4\u30f3\u306bAlphaFold2\u304c\u4e88\u6e2c\u3057\u305f\u3088\u3046\u306bC1A\u3092\u7d50\u5408\u3055\u305b\u308b\u3068\u3001\u4eca\u5ea6\u306f\u507d\u57fa\u8cea\u914d\u5217\u304c\u89e6\u5a92\u30c9\u30e1\u30a4\u30f3\u306e\u6d3b\u6027\u90e8\u4f4d\u306b\u5c4a\u304b\u306a\u304f\u306a\u308a\u3001\u77db\u76fe\u304c\u751f\u3058\u307e\u3059\u3002\u3084\u306f\u308a\u3001PKC\u03b2\u306e\u7d50\u6676\u69cb\u9020\u3067\u96fb\u5b50\u5bc6\u5ea6\u304c\u898b\u3048\u3066\u3044\u306a\u3044\u3053\u3068\u304b\u3089\u3082\u5206\u304b\u308b\u901a\u308a\u3001C1A\u30c9\u30e1\u30a4\u30f3\u306f\u304b\u306a\u308a\u3075\u3089\u3075\u3089\u3057\u305f\u4f4d\u7f6e\u306b\u3042\u308a\u3001\u4e0d\u6d3b\u6027\u578b\u9175\u7d20\u3067\u306fC1B\u30c9\u30e1\u30a4\u30f3\u3068\u5f37\u56fa\u306b\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u3001C1B\u30c9\u30e1\u30a4\u30f3\u304c\u89e6\u5a92\u30c9\u30e1\u30a4\u30f3\u304b\u3089\u5916\u308c\u3066\u9175\u7d20\u304c\u6d3b\u6027\u578b\u306b\u306a\u3063\u305f\u5834\u5408\u306f\u3001AlphaFold2\u304c\u4e88\u6e2c\u3057\u305f\u3088\u3046\u306b\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u306e\u3088\u3046\u306b\u306a\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<h2>C1A\u3068C1B\u30c9\u30e1\u30a4\u30f3\u306e\u76f8\u4e92\u4f5c\u7528<\/h2>\n<p>C1\u30c9\u30e1\u30a4\u30f3\u306b\u3064\u3044\u3066\u306f\u3001\u3069\u308c\u3082\uff08\u30c9\u30e1\u30a4\u30f3\u3092\u9854\u306b\u4f8b\u3048\u308b\u3068\uff09C1A\u3001C1B\u30c9\u30e1\u30a4\u30f3\u3068\u3082\u4e0a\u4e0b\u306f\u540c\u3058\u5411\u304d\u306b\u63c3\u3063\u3066\u3044\u3066\u3001C1B\u30c9\u30e1\u30a4\u30f3\u304c\u9f3b\u3092C1A\u30c9\u30e1\u30a4\u30f3\u306e\u53f3\u982c\u306b\u62bc\u3057\u4ed8\u3051\u3066\u3044\u308b\u3088\u3046\u306a\u914d\u7f6e\u3067\u3059\u3002C1A\u30c9\u30e1\u30a4\u30f3\u3068C1B\u30c9\u30e1\u30a4\u30f3\u306e\u9593\u306f\u7d0420\u6b8b\u57fa\u306e\u30ea\u30f3\u30ab\u30fc\u90e8\u4f4d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u304c\u7d0470\u6b8b\u57fa\u96e2\u308c\u3066\u3044\u308bPKD\u3067\u306fC1A\u3068C1B\u30c9\u30e1\u30a4\u30f3\u9593\u306epredicted aligned error\u306f\u9ad8\u304f\u3001\u4fe1\u983c\u6027\u304c\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>PKD1 (human) <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q15139\">https:\/\/alphafold.ebi.ac.uk\/entry\/Q15139<\/a><\/li>\n<\/ul>\n<p>\u30ea\u30f3\u30ab\u30fc\u306e\u5b58\u5728\u3084\u9577\u3055\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u304b\u8abf\u3079\u3088\u3046\u3068\u3001Google Colaboratory\u7248\u3092\u4f7f\u3063\u3066\u8907\u5408\u4f53\u69cb\u9020\u306e\u4e88\u6e2c\u3092\u884c\u3044\u307e\u3057\u305f\uff08\u30c9\u30e1\u30a4\u30f3\u9593\u306b\u30a2\u30df\u30ce\u9178\u8a18\u53f7U\uff08Unknown\uff09\u00d7 &gt;32\u500b\u3092\u633f\u5165\u3059\u308b\uff09\u3002\u3053\u3046\u3044\u3046\u3053\u3068\u304c\u7c21\u5358\u306b\u3067\u304d\u3066\u3057\u307e\u3046\u306e\u304c\u4fbf\u5229\u3067\u3059\u3002<\/p>\n<p>PKC\u03b1\u306e\u5834\u5408\u306f\u30ea\u30f3\u30ab\u30fc\u304c\u3042\u3063\u3066\u3082\u306a\u304f\u3066\u3082\u4e0a\u8a18\u306e\u8907\u5408\u4f53\u69cb\u9020\u304c\u4e88\u6e2c\u3068\u3057\u3066\u3067\u3066\u304d\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-2737\" src=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-1024x858.png\" alt=\"\" width=\"640\" height=\"536\" srcset=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-1024x858.png 1024w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-300x251.png 300w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-768x643.png 768w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-322x270.png 322w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b.png 1280w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p>\u30c9\u30e1\u30a4\u30f3\u306e\u914d\u7f6e\u306e\u4fe1\u983c\u6027\u3082\u9ad8\u3044\u3067\u3059\uff08\u5bfe\u89d2\u7dda\u4e0a\u306e\u9752\u3044\u56db\u89d2\u306e\u30d6\u30ed\u30c3\u30af\u304c\u5404\u30c9\u30e1\u30a4\u30f3\u306e\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u4fe1\u983c\u6027\u3001\u53f3\u4e0a\/\u5de6\u4e0b\u306e\u9752\u8272\u30d6\u30ed\u30c3\u30af\u304c\u30c9\u30e1\u30a4\u30f3\u306e\u914d\u7f6e\u306e\u4fe1\u983c\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3059\u3002\u8d64\u3044\u90e8\u5206\u306fUnknown linker\u306e\u90e8\u5206\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-2738\" src=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKCA_C1A_Ulinker_C1B_3e395_PAE-1024x137.png\" alt=\"\" width=\"640\" height=\"86\" srcset=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKCA_C1A_Ulinker_C1B_3e395_PAE-1024x137.png 1024w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKCA_C1A_Ulinker_C1B_3e395_PAE-300x40.png 300w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKCA_C1A_Ulinker_C1B_3e395_PAE-768x102.png 768w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKCA_C1A_Ulinker_C1B_3e395_PAE-360x48.png 360w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKCA_C1A_Ulinker_C1B_3e395_PAE.png 1500w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p>\u5bfe\u3057\u3066\u3001PKD1\u306e\u5834\u5408\u306f\u4e00\u5b9a\u3057\u305f\u8907\u5408\u4f53\u69cb\u9020\u306f\u4e88\u6e2c\u3055\u308c\u305a\u3001\u30c9\u30e1\u30a4\u30f3\u306e\u914d\u7f6e\u306e\u4fe1\u983c\u6027\u3082\u4f4e\u3044\u7d50\u679c\u3067\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-2739\" src=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/pkd1c1ac1b-1024x858.png\" alt=\"\" width=\"640\" height=\"536\" srcset=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/pkd1c1ac1b-1024x858.png 1024w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/pkd1c1ac1b-300x251.png 300w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/pkd1c1ac1b-768x643.png 768w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/pkd1c1ac1b-322x270.png 322w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/pkd1c1ac1b.png 1280w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-2740\" src=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKD1_C1A_Ulinker_C1B_7768a_PAE-1024x137.png\" alt=\"\" width=\"640\" height=\"86\" srcset=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKD1_C1A_Ulinker_C1B_7768a_PAE-1024x137.png 1024w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKD1_C1A_Ulinker_C1B_7768a_PAE-300x40.png 300w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKD1_C1A_Ulinker_C1B_7768a_PAE-768x102.png 768w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKD1_C1A_Ulinker_C1B_7768a_PAE-360x48.png 360w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/PRKD1_C1A_Ulinker_C1B_7768a_PAE.png 1500w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p>AlphaFold2\u306e\u4e2d\u8eab\u3092\u7406\u89e3\u3057\u3066\u3044\u306a\u3044\u306e\u3067\u3001\u3069\u3046\u3044\u3063\u305f\u6839\u62e0\u3067\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u4f4e\u3044\u3092\u5224\u65ad\u3057\u3066\u3044\u308b\u306e\u304b\u306f\u5206\u304b\u308a\u307e\u305b\u3093\u3002\u540c\u69d8\u306b\u8907\u6570\uff082\u3064\u307e\u305f\u306f3\u3064\uff09\u306eC1\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u3064diacylglycerol kinase (DGK) \u30d5\u30a1\u30df\u30ea\u30fc\u3067\u306fC1\u30c9\u30e1\u30a4\u30f3\u9593\u3067\u3082C1\u30c9\u30e1\u30a4\u30f3\u2013\u4ed6\u30c9\u30e1\u30a4\u30f3\u9593\u3067\u3082\u914d\u7f6e\u306e\u4fe1\u983c\u6027\u304c\u9ad8\u3044\u4e88\u6e2c\u69cb\u9020\u304c\u51fa\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u51fa\u3066\u6765\u305f\u7acb\u4f53\u69cb\u9020\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6700\u5c0f\u5316\u3092\u3059\u308b\u5834\u5408\u3001\u81ea\u5206\u3067\u4e9c\u925b\u30a4\u30aa\u30f3\u3092\u633f\u5165\u3057\u3066\u3001<a href=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/memo\/md-simulation\/\">\u4ee5\u524d\u66f8\u3044\u305f\u65b9\u6cd5<\/a>\u3067AMBER\u304bGROMACS\u3092\u4f7f\u3063\u3066\u5b9f\u884c\u3067\u304d\u307e\u3059\u3002<\/p>\n<h2>\u4e8c\u91cf\u4f53\u578bC1\u30c9\u30e1\u30a4\u30f3\u30ea\u30ac\u30f3\u30c9<\/h2>\n<p>PKC\u306b\u306f2\u3064\u306eC1\u30c9\u30e1\u30a4\u30f3\u304c\u4e26\u3093\u3067\u5b58\u5728\u3057\u307e\u3059\u304c\u3001\u5929\u7136\u304b\u3089\u306f\u4e8c\u91cf\u4f53\u578bC1\u30c9\u30e1\u30a4\u30f3\u30ea\u30ac\u30f3\u30c9 (blastmycetin A) \u306e\u5358\u96e2\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>\n<p>Hagiwara, N.; Irie, K.; Funaki, A.; Hayashi, H.; Arai, M.; Koshimizu, K. Structure and Tumor-promoting Activity of New Teleocidin-related Metabolites (Blastmycetins) from <em>Streptoverticillium blastmyceticum<\/em>. <em>Agric. Biol. Chem<\/em>. <strong>1988<\/strong>, <em>52<\/em>, 641\u2013648. DOI: <a href=\"https:\/\/doi.org\/10.1271\/bbb1961.52.641\">10.1271\/bbb1961.52.641<\/a><\/p>\n<\/li>\n<\/ul>\nBlastmycetin A\u4e2d\u306e\u30ea\u30f3\u30ab\u30fc\u306f\u30e1\u30c1\u30ec\u30f3\u57fa1\u3064\u3067\u3059\u306e\u3067\u30012\u3064\u306eC1\u30c9\u30e1\u30a4\u30f3\u3068\u8102\u8cea\u4e8c\u91cd\u819c\u3068\u540c\u6642\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u4e00\u65b9\u3067\u30012\u3064\u306eC1\u30c9\u30e1\u30a4\u30f3\u306b\u540c\u6642\u306b\u7d50\u5408\u3059\u308b\u3088\u3046\u610f\u56f3\u3057\u3066\u8a2d\u8a08\u3055\u308c\u305f\u4e8c\u91cf\u4f53\u578bC1\u30c9\u30e1\u30a4\u30f3\u30ea\u30ac\u30f3\u30c9\u304c\u3044\u304f\u3064\u304b\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n<ul>\n<li>Wender, P. A.; Kehler, M. F. T.; Wright, D. L.; Irie, K. Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): The Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers. <em>Synthesis<\/em> <strong>1999<\/strong>, <em>S1<\/em>, 1401\u20131406. DOI: <a href=\"http:\/\/doi.org\/10.1055\/s-1999-3656\">10.1055\/s-1999-3656<\/a><\/li>\n<li>Sridhar, J.; Wei, Z.; Nowak, I.; Lewin, N. E.; Ayres, J. A.; Pearce, L. V.; Blumberg, P. M.; Kozikowski, A. P. New Bivalent PKC Ligands Linked by a Carbon Spacer: Enhancement in Binding Affinity. <em>J. Med. Chem.<\/em> <strong>2003<\/strong>,&nbsp;<em>46<\/em>, 4196\u2013 4204. DOI: <a href=\"https:\/\/doi.org\/10.1021\/jm0302041\">10.1021\/jm0302041<\/a><\/li>\n<li>Ohashi, N.; Kobayashi, R.; Nomura, W.; Kobayakawa, T.; Czikora, A.; Herold, B. K.; Lewin, N. E.; Blumberg, P. M.; Tamamura, H. Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol\u2013Lactones as Protein Kinase C Ligands. <em>Bioconjugate Chem<\/em>. <strong>2017<\/strong>, <em>28<\/em>, 2135\u20132144. DOI: <a href=\"https:\/\/doi.org\/10.1021\/acs.bioconjchem.7b00299\">10.1021\/acs.bioconjchem.7b00299<\/a><\/li>\n<\/ul>\n<p>\u3053\u308c\u3089\u306e\u6700\u9069\u306a\u30ea\u30f3\u30ab\u30fc\u9577\u3092\u4eca\u56de\u306e\u4e88\u6e2c\u69cb\u9020\u304b\u3089\u5408\u7406\u7684\u306b\u8aac\u660e\u3067\u304d\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u4e0a\u8a18\u306e2\u756a\u76ee\u306e\u8ad6\u6587\uff08Sridhar <em>et al<\/em>., 2003\uff09\u306e\u30ea\u30ac\u30f3\u30c9\u5358\u91cf\u4f53\u3092PKC\u03b1 C1A-C1B\u30c9\u30e1\u30a4\u30f3\u306e\u4e88\u6e2c\u8907\u5408\u4f53\u69cb\u9020\u306b\u914d\u7f6e\u3057\u3066\u8ddd\u96e2\u3092\u6e2c\u3063\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-2744\" src=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/dimer_dock-1024x858.png\" alt=\"\" width=\"640\" height=\"536\" srcset=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/dimer_dock-1024x858.png 1024w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/dimer_dock-300x251.png 300w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/dimer_dock-768x643.png 768w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/dimer_dock-322x270.png 322w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/dimer_dock.png 1280w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p>\u30a2\u30eb\u30ad\u30eb\u76f4\u9396\u3067\u3064\u306a\u304c\u308c\u3066\u3044\u305f\u70ad\u7d20\u9593\u306e\u8ddd\u96e2\u306f\u76f4\u7dda\u3067\u308221 \u00c5\u3042\u3063\u3066\u3001\u8ad6\u6587\u3067\u6700\u9069\u3060\u3063\u305f\u70ad\u7d20\u657014\u3067\u306f\u5c4a\u304d\u305d\u3046\u3082\u3042\u308a\u307e\u305b\u3093\uff08\u3064\u306a\u3044\u3067\u307f\u305f\u3089\u70ad\u7d20\u304c23\u500b\u5fc5\u8981\u3067\u3057\u305f\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-2745\" src=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/withlinker-1024x858.png\" alt=\"\" width=\"640\" height=\"536\" srcset=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/withlinker-1024x858.png 1024w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/withlinker-300x251.png 300w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/withlinker-768x643.png 768w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/withlinker-322x270.png 322w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/withlinker.png 1280w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p>\u8a2d\u8a08\u306e\u610f\u56f3\u901a\u308a\u306b\u30c0\u30a4\u30de\u30fc\u304c2\u3064\u306e\u30c9\u30e1\u30a4\u30f3\u306b\u7d50\u5408\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30c9\u30e1\u30a4\u30f3\u5074\u304cAlphaFold2\u306e\u4e88\u6e2c\u69cb\u9020\u3068\u306f\u5225\u306e\u914d\u7f6e\u3092\u53d6\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u30e1\u30e2:<\/p>\n<ul>\n<li>PKC\u03b2II\u306e\u307b\u307c\u5168\u9577\u7d50\u6676\u69cb\u9020\uff08<a href=\"https:\/\/www.rcsb.org\/structure\/3pfq\">https:\/\/www.rcsb.org\/structure\/3pfq<\/a>\uff09\u3067\u898b\u3089\u308c\u305fC1B\u30c9\u30e1\u30a4\u30f3\u306e\u30ea\u30ac\u30f3\u30c9\u7d50\u5408cleft\u3068\u30ad\u30ca\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306fAlphaFold2\u3067\u306f\u518d\u73fe\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u3002<\/li>\n<li>PKC\u03b2II\u306e\u7d50\u6676\u69cb\u9020\u3067\u306fC1A\u30c9\u30e1\u30a4\u30f3\u306e\u96fb\u5b50\u5bc6\u5ea6\u306f\u898b\u3048\u3066\u3044\u306a\u3044\u306e\u3067\u3001C1A\u3068C1B\u30c9\u30e1\u30a4\u30f3\u306e\u8907\u5408\u4f53\u69cb\u9020\u306f\u305d\u308c\u307b\u3069\u5f37\u3044\u3082\u306e\u3067\u306f\u306a\u3044\u3002<\/li>\n<li>PKC\u306e\u57fa\u8cea\u30e2\u30c1\u30fc\u30d5\u914d\u5217\u306fRXXS\/TXRX\uff08X\u306f\u4efb\u610f\u306e\u30a2\u30df\u30ce\u9178\uff09(Pearson &amp; Kemp, 1991)\u3002<\/li>\n<\/ul>\n<h2>\u53c2\u8003\u6587\u732e<\/h2>\n<ul>\n<li>Gong, J.; Holwinski, R. J.; Van Eyk, J. E.; Steinberg, S. F. A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-\u03b4. <em>Biochem J<\/em>. <strong>2016<\/strong>, <em>473<\/em>, 311\u2013320. &nbsp;DOI: <a href=\"https:\/\/doi.org\/10.1042\/BJ20150812\">10.1042\/BJ20150812<\/a>.&nbsp; PMCID: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5022567\/\">PMC5022567<\/a>.<\/li>\n<li>Pearson, R. B.; Kemp, B. E. Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations. <em>Methods Enzymol<\/em>. <strong>1991<\/strong>, <em>200<\/em>, 62\u201381. DOI: <a href=\"https:\/\/doi.org\/10.1016\/0076-6879(91)00127-I\">10.1016\/0076-6879(91)00127-I<\/a><\/li>\n<\/ul>\n<h2>\u305d\u306e\u4ed6\u306eC1\u30c9\u30e1\u30a4\u30f3\u542b\u6709\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u306e\u30ea\u30f3\u30af<\/h2>\n<h3>DAG\u7d50\u5408\u80fd\u3092\u6301\u3064\u3082\u306e<\/h3>\n<ul>\n<li>Protein kinase D<a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q15139\">1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q9BZL6\">2<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/O94806\">3<\/a><\/li>\n<li>Chimaerin <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P15882\">\u03b12<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P52757\">\u03b22<\/a><\/li>\n<li>DAG kinase <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P49621\">\u03b2<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q91WG7\">\u03b3<\/a><\/li>\n<li>Munc13-<a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q9UPW8\">1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/O14795\">2<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q8NB66\">3<\/a><\/li>\n<li>RasGRP <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/O95267\">1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q7LDG7\">2<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q8IV61\">3<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q8TDF6\">4<\/a><\/li>\n<li>MRCK <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q5VT25\">\u03b1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q9Y5S2\">\u03b2<\/a><\/li>\n<\/ul>\n<h3>DAG\u7d50\u5408\u80fd\u3092\u6301\u305f\u306a\u3044\u3082\u306e<\/h3>\n<ul>\n<li>MRCK <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q6DT37\">\u03b3<\/a><\/li>\n<li>DAG kinase <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/O88673\">\u03b1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q16760\">\u03b4<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q13574\">\u03b6<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P52429\">\u03b5<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q86XP1\">\u03b7<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P52824\">\u03b8<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/O75912\">\u03b9<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q5KSL6\">\u03ba<\/a><\/li>\n<li>Vav <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P15498\">1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P52735\">2<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q9UKW4\">3<\/a><\/li>\n<li><a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/P04049\">Raf-1<\/a><\/li>\n<li>KSR <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q8IVT5\">1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q6VAB6\">2<\/a><\/li>\n<li>ROCK <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q13464\">1<\/a>, <a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/O75116\">2<\/a><\/li>\n<li><a href=\"https:\/\/alphafold.ebi.ac.uk\/entry\/Q8WWW0\">RASSF5<\/a><\/li>\n<\/ul>\n<p>(\u4e86)<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AlphaFold2 Alphabet Inc. \u5098\u4e0b\u306eDe &#8230;<\/p>\n","protected":false},"author":1,"featured_media":2737,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_locale":"","_original_post":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-2730","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","ja"],"aioseo_notices":[],"uagb_featured_image_src":{"full":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b.png",1280,1072,false],"thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-150x150.png",150,150,true],"medium":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-300x251.png",300,251,true],"medium_large":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-768x643.png",768,643,true],"large":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b-1024x858.png",800,670,true],"1536x1536":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b.png",1280,1072,false],"2048x2048":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b.png",1280,1072,false],"onepress-blog-small":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b.png",179,150,false],"onepress-small":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b.png",358,300,false],"onepress-medium":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2021\/07\/prkcac1ac1b.png",478,400,false]},"uagb_author_info":{"display_name":"RCY","author_link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/author\/charlesy\/"},"uagb_comment_info":0,"uagb_excerpt":"AlphaFold2 Alphabet Inc. \u5098\u4e0b\u306eDe 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