{"id":3908,"date":"2023-09-12T17:32:16","date_gmt":"2023-09-12T08:32:16","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/?p=3908"},"modified":"2023-10-11T16:11:34","modified_gmt":"2023-10-11T07:11:34","slug":"simplified-analogues-of-natural-products-published-in-2019","status":"publish","type":"post","link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/2023\/09\/12\/simplified-analogues-of-natural-products-published-in-2019\/","title":{"rendered":"Simplified analogues of natural products published in 2019"},"content":{"rendered":"\n\n\n<p>Google Scholar search results for \u201c\u201dsimplified analogue\u201d natural products\u201d, \u201c\u201dsimplified analogues\u201d natural products\u201d, \u201c\u201dsimplified-analog\u201d natural products\u201d, \u201c\u201dsimplified analogs\u201d natural products\u201d, \u201c\u201dfunction-oriented-synthesis\u201d natural products\u201d, and \u201cpseudo-natural-products\u201d<\/p>\n<p>Reviews published in 2019:<\/p>\n<ul>\n<li>Wang S, Dong G, Sheng C. Structural Simplification of Natural Products. Chem Rev. 2019 Mar 27;119(6):4180-4220. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.8b00504\">10.1021\/acs.chemrev.8b00504<\/a>. Epub 2019 Feb 7. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30730700\/\">30730700<\/a>.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-4037\" src=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-1024x576.png\" alt=\"\" width=\"800\" height=\"450\" srcset=\"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-1024x576.png 1024w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-300x169.png 300w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-768x432.png 768w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-1536x864.png 1536w, https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-2048x1152.png 2048w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/a><\/p>\n\n\n\n<ol>\n<li><span style=\"color: #000000;\">Abbasov ME, Alvari\u00f1o R, Chaheine CM, Alonso E, S\u00e1nchez JA, Conner ML, Alfonso A, Jaspars M, Botana LM, Romo D. Simplified immunosuppressive and neuroprotective agents based on gracilin A. Nat Chem. 2019 Apr;11(4):342-350. doi: <a href=\"https:\/\/doi.org\/10.1038\/s41557-019-0230-0\">10.1038\/s41557-019-0230-0<\/a>. Epub 2019 Mar 22. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30903037\/\">30903037<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6532426\/\">PMC6532426<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Mor\u00e3o LG, Polaquini CR, Kopacz M, Torrezan GS, Ayusso GM, Dilarri G, Cavalca LB, Zieli\u0144ska A, Scheffers DJ, Regasini LO, Ferreira H. A simplified curcumin targets the membrane of <em>Bacillus subtilis<\/em>. Microbiologyopen. 2019 Apr;8(4):e00683. doi: <a href=\"https:\/\/doi.org\/10.1002\/mbo3.683\">10.1002\/mbo3.683<\/a>. Epub 2018 Jul 26. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30051597\/\">30051597<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6460283\/\">PMC6460283<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chany AC, Legros F, Haroun H, Kundu UK, Biletskyi B, Torlak S, Math\u00e9-Allainmat M, Lebreton J, Mac\u00e9 A, Carboni B, Renoux B, Gosselin P, Dujardin G, Gaulon-Nourry C. Function-Oriented Synthesis toward Peloruside A Analogues. Org Lett. 2019 May 3;21(9):2988-2992. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.9b00413\">10.1021\/acs.orglett.9b00413<\/a>. Epub 2019 Mar 12. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30859834\/\">30859834<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Ashida Y, Yanagita RC, Kawanami Y, Okamura M, Dan S, Irie K. Synthesis, Conformation, and Biological Activities of a Des-A-Ring Analog of 18-Deoxy-Aplog-1, a Simplified Analog of Debromoaplysiatoxin. Heterocycles. 2019; 99(2):942-957. doi: <a href=\"https:\/\/doi.org\/10.3987\/COM-18-S(F)60\">10.3987\/COM-18-S(F)60<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Pierrot D, Sinou V, Bun SS, Parzy D, Taudon N, Rodriguez J, Ollivier E, Bonne D. Design and synthesis of simplified speciophylline analogues and \u03b2-carbolines as active molecules against <em>Plasmodium falciparum<\/em>. Drug Dev Res. 2019 Feb;80(1):133-137. doi: <a href=\"https:\/\/doi.org\/10.1002\/ddr.21494\">10.1002\/ddr.21494<\/a>. Epub 2018 Nov 29. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30499121\/\">30499121<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Qiao L, Duan Z, Chen Y, Luan Y, Gu Q, Liu YK, Li D. Aspergiolides A and B: Core Structural Establishment and Synthesis of Structural Analogues. J Org Chem. 2019 Apr 5;84(7):4451-4457. doi: <a href=\"https:\/\/doi.org\/10.1021\/acs.joc.8b03185\">10.1021\/acs.joc.8b03185<\/a>. Epub 2019 Mar 21. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30865441\/\">30865441<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Henry JL, Wilson MR, Mulligan MP, Quinn TR, Sackett DL, Taylor RE. Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (\u2212)-zampanolide and (\u2212)-dactylolide. Medchemcomm. 2019 Apr 9;10(5):800-805. doi: <a href=\"https:\/\/doi.org\/10.1039\/c9md00164f\">10.1039\/c9md00164f<\/a>. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31191870\/\">31191870<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6540953\/\">PMC6540953<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Sosonyuk SE, Peshich A, Tutushkina AV, Khlevin DA, Lozinskaya NA, Gracheva YA, Glazunova VA, Osolodkin DI, Semenova MN, Semenov VV, Palyulin VA, Proskurnina MV, Shtil AA, Zefirov NS. Synthesis and cytotoxicity of novel simplified eleutherobin analogues as potential antitumour agents. Org Biomol Chem. 2019 Mar 6;17(10):2792-2797. doi: <a href=\"https:\/\/doi.org\/10.1039\/c8ob02915f\">10.1039\/c8ob02915f<\/a>. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30793716\/\">30793716<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Zacharova MK, Tulloch LB, Gould ER, Fraser AL, King EF, Menzies SK, Smith TK, Florence GJ. Structure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase. European J Org Chem. 2019 Sep 1;2019(31-32):5434-5440. doi: <a href=\"https:\/\/doi.org\/10.1002\/ejoc.201900541\">10.1002\/ejoc.201900541<\/a>. Epub 2019 May 29. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31598093\/\">31598093<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6774295\/\">PMC6774295<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Evans DM, Hughes J, Jones LF, Murphy PJ, Falfushynska H, Horyn O, Sokolova IM, Christensen J, Coles SJ, Rzymski P. Elucidating cylindrospermopsin toxicity via synthetic analogues: An in&nbsp;vitro approach. Chemosphere. 2019 Nov;234:139-147. doi: <a href=\"https:\/\/doi.org\/10.1016\/j.chemosphere.2019.06.021\">10.1016\/j.chemosphere.2019.06.021<\/a>. Epub 2019 Jun 10. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31207420\/\">31207420<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Monjas L, Fodran P, Kollback J, Cassani C, Olsson T, Genheden M, Larsson DGJ, Wallentin CJ. Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents. Beilstein J Org Chem. 2019 Jul 2;15:1468-1474. doi: <a href=\"https:\/\/doi.org\/10.3762\/bjoc.15.147\">10.3762\/bjoc.15.147<\/a>. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31354863\/\">31354863<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6633193\/\">PMC6633193<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\"><span class=\"cited-content_cbyCitation_article-contributors\"><span class=\"hlFld-ContribAuthor \">Kalmode HP<\/span>, <span class=\"hlFld-ContribAuthor \">Patil SS<\/span>, <span class=\"hlFld-ContribAuthor \">Handore KL<\/span>, <span class=\"hlFld-ContribAuthor \">Athawale PR<\/span>, <span class=\"hlFld-ContribAuthor \">Dandela R<\/span>, <span class=\"hlFld-ContribAuthor \">Verma AK<\/span>, <span class=\"hlFld-ContribAuthor \">Basu A<\/span>, <span class=\"hlFld-ContribAuthor \">Reddy DS<\/span>.&nbsp;<\/span><span class=\"cited-content_cbyCitation_article-title\">Neural Anti\u2010Inflammatory Natural Product Periconianone A: Total Synthesis and Biological Evaluation.&nbsp;<\/span><span class=\"cited-content_cbyCitation_journal-name\">European J Org Chem.<\/span> 2019;2019(13):2376-2381. doi: <a href=\"https:\/\/doi.org\/10.1002\/ejoc.201900048\">10.1002\/ejoc.201900048<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Solinski AE, Scharnow AM, Fraboni AJ, Wuest WM. Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in&nbsp;<i>Streptococcus mutans<\/i>. ACS Infect Dis. 2019 Aug 9;5(8):1480-1486. doi: <a href=\"https:\/\/doi.org\/10.1021\/acsinfecdis.9b00213\">10.1021\/acsinfecdis.9b00213<\/a>. Epub 2019 Jun 25. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31243986\/\">31243986<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7169375\/\">PMC7169375<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Ali R, Guan Y, Leveille AN, Vaughn E, Parelkar S, Thompson PR, Mattson AE. Synthesis and Anticancer Activity of Structure Simplified Naturally-Inspired Dimeric Chromenone Derivatives. European J Org Chem. 2019 Nov 10;2019(41):6917-6929. doi: <a href=\"https:\/\/doi.org\/10.1002\/ejoc.201901026\">10.1002\/ejoc.201901026<\/a>. Epub 2019 Aug 27. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33828411\/\">33828411<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8023304\/\">PMC8023304<\/a>.<\/span><\/li>\n<li><span style=\"color: #000000;\">Tysoe CR, Caner S, Calvert MB, Win-Mason A, Brayer GD, Withers SG. Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic \u03b1-amylase. Chem Sci. 2019 Oct 18;10(48):11073-11077. doi: <a href=\"https:\/\/doi.org\/10.1039\/c9sc02610j\">10.1039\/c9sc02610j<\/a>. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32206255\/\">32206255<\/a>; PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7069248\/\">PMC7069248<\/a>.<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4037,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_locale":"ja","_original_post":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/?p=3908","footnotes":""},"categories":[9],"tags":[],"class_list":["post-3908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-9","ja"],"aioseo_notices":[],"uagb_featured_image_src":{"full":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019.png",4000,2250,false],"thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-150x150.png",150,150,true],"medium":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-300x169.png",300,169,true],"medium_large":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-768x432.png",768,432,true],"large":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-1024x576.png",800,450,true],"1536x1536":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-1536x864.png",1536,864,true],"2048x2048":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-2048x1152.png",2048,1152,true],"onepress-blog-small":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-300x150.png",300,150,true],"onepress-small":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-480x300.png",480,300,true],"onepress-medium":["https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp\/wp-content\/uploads\/2023\/10\/Simplified_analogs_2019-640x400.png",640,400,true]},"uagb_author_info":{"display_name":"RCY","author_link":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/author\/charlesy\/"},"uagb_comment_info":0,"uagb_excerpt":null,"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/posts\/3908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/comments?post=3908"}],"version-history":[{"count":8,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/posts\/3908\/revisions"}],"predecessor-version":[{"id":4039,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/posts\/3908\/revisions\/4039"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/media\/4037"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/media?parent=3908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/categories?post=3908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/charlesy\/wp-json\/wp\/v2\/tags?post=3908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}