{"id":88,"date":"2021-02-02T22:41:20","date_gmt":"2021-02-02T13:41:20","guid":{"rendered":"\/?page_id=88"},"modified":"2025-11-23T00:21:31","modified_gmt":"2025-11-22T15:21:31","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/?page_id=88","title":{"rendered":"Publications"},"content":{"rendered":"

Peer-Reviewed Papers<\/strong><\/h4>\n

\uff08Bold<\/strong> : Lab member,\u00a0 *<\/strong> Corresponding author\uff09<\/p>\n

 <\/p>\n

Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C<\/strong><\/a>.<\/p>\n

Mana Morishita, Kohei Hada, Yusuke Araki, Keisuke Fukaya, Daisuke Urabe, Ryo C. Yanagita, Jumpei Maki, Yusuke Hanaki<\/strong>, Masaki Kita, Kazuhiro Irie, Toshio Nishikawa*<\/strong>.<\/p>\n

Eur. J. Org. Chem.<\/em> 2025<\/strong>, 28 (42), e202500890.<\/p>\n

 <\/p>\n

Production of rare sugars by transketolase in combination with ketose 3-epimerase<\/strong><\/a>.<\/p>\n

Akihide Yoshihara*<\/strong>, Yusuke Hanaki<\/strong>, Susumu Mochizuki, Hiromi Yoshida, Ken Izumori, Shigehiro Kamitori.<\/p>\n

Methods Enzymol.<\/em> 2025<\/strong>, 772 (2025), 429\u2013446.<\/p>\n

 <\/p>\n

Synthetic Study of 8- and 9-Carbon Sugars by Transaldolase<\/strong><\/a>.<\/p>\n

Akihide Yoshihara*<\/strong>, Erika Miyoshi, Shunsuke Tomino, Yusuke Hanaki<\/strong>, Susumu Mochizuki, Hiromi Yoshida, Ken Izumori, Shigehiro Kamitori*<\/strong>.<\/p>\n

J. Agric. Food Chem.<\/em> 2025<\/strong>, 73 (30), 18914\u201318922.<\/p>\n

 <\/p>\n

Efficient production of D-sedoheptulose using transketolase from Thermus thermophilus<\/em> HB8 and epimerization reaction using D-tagatose 3-epimerase from Pseudomonas cichorii<\/em> ST24<\/strong><\/a>.<\/p>\n

Kana Watanuki, Susumu Mochizuki, Yusuke Hanaki<\/strong>, Hiromi Yoshida, Shigehiro Kamitori, Ken Izumori, Akihide Yoshihara*<\/strong>.<\/p>\n

Biosci. Biotechnol. Biochem.<\/em> 2025<\/strong>, 89 (9), 1279\u20131285.<\/p>\n

 <\/p>\n

Six-step synthesis and epithelial\u2013mesenchymal transition-inhibitory activity of a tetralone-based vitetrifolin analog<\/strong><\/a>. \"\"<\/a><\/p>\n

Yusuke Hanaki*<\/strong>, Yasunori Sugiyama, Ryo C. Yanagita.<\/p>\n

Biosci. Biotechnol. Biochem.<\/em> 2025<\/strong>, 89 (6), 805\u2013810. \"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Identification of lotus cultivar-specific rhizome compounds and evaluation of thier growth inhibitory activity against Fusarium commune<\/em><\/strong><\/a>. \"\"<\/a><\/p>\n

Yusuke Hanaki*<\/strong>, Yasumasa Hara, Miu Mori, Keita Tomiyoshi.<\/p>\n

Fundam. Toxicol. Sci.<\/em> 2025<\/strong>, 12 (1), 1\u20135. \"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R<\/em>)-(\u2013)-carvone-based core<\/strong><\/a>.<\/p>\n

Ryo C. Yanagita*<\/strong>, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki<\/strong>, Kazuhiro Irie.<\/p>\n

Biosci. Biotechnol. Biochem.<\/em> 2024<\/strong>, 88 (9), 992\u2013998.<\/p>\n

 <\/p>\n

A new labdane-type diterpenoid from leaves of Vitex rotundifolia<\/em><\/strong><\/a>. \"\"<\/a><\/p>\n

Yusuke Hanaki*<\/strong>, Rintaro Abe<\/strong>, Yasunori Sugiyama, Yasumasa Hara, Ryo C. Yanagita.<\/p>\n

Results Chem.<\/em>\u00a02024<\/strong>, 7, 101512. \"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation<\/strong><\/a>.<\/p>\n

Jumpei Maki, Yusuke Hanaki<\/strong>, Ryo C. Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie*<\/strong>.<\/p>\n

Biosci. Biotechnol. Biochem.<\/em> 2023<\/strong>, 87 (12), 1453\u20131461.<\/p>\n

 <\/p>\n

In vivo<\/em> anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest<\/strong><\/a>.<\/p>\n

Yusuke Hanaki<\/strong>, Yuki Shikata, Masayuki Kikumori, Mutsumi Okamura, Shingo Dan, Masaya Imoto, Kazuhiro Irie*<\/strong>.<\/p>\n

Biochem. Biophys. Res. Commun.<\/em> 2023<\/strong>, 675, 19\u201325.<\/p>\n

 <\/p>\n

Cell Morphology-Based Screening Identified Vitetrifolin D from <\/strong>Vitex Rotundifolia<\/em><\/strong> as an Inhibitor of Phorbol Ester-Induced Downregulation of E-Cadherin in HHUA Endometrial Cells<\/strong><\/a>. \"\"<\/a><\/p>\n

Yusuke Hanaki*<\/strong>, Nichika Iwase<\/strong>, Yasunori Sugiyama, Sena Miyoshi<\/strong>, Ryo C. Yanagita.<\/p>\n

BPB Reports<\/em> 2023<\/strong>, 6 (3), 103-107. \"\"<\/a><\/p>\n

\"\"<\/p>\n

 <\/p>\n

A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities<\/a><\/strong>.<\/p>\n

Tomoki Sekido, Kosuke Yamamoto, Ryo C. Yanagita*<\/strong>, Yasuhiro Kawanami, Yusuke Hanaki<\/strong>, Kazuhiro Irie.<\/p>\n

Bioorg. Med. Chem. <\/em>2022<\/strong>, 73, 116988.<\/p>\n

 <\/p>\n

12-<\/strong>O<\/em><\/strong>-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial\u2013mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases<\/strong><\/a>.<\/p>\n

Yusuke Hanaki*<\/strong>, Sena Miyoshi<\/strong>, Yasunori Sugiyama, Ryo C. Yanagita, Masashi Sato.<\/p>\n

Biosci. Biotechnol. Biochem.<\/em> 2022<\/strong>, 86 (10), 1417-1422. [Accepted Manuscript\"\"<\/strong><\/a>]<\/p>\n

\"\"<\/p>\n

 <\/p>\n

Design, synthesis, and biological activity of synthetically accessible analog of aplysiatoxin with (<\/strong>R<\/em><\/strong>)-(\u2013)-carvone-based conformation-controlling unit<\/strong><\/a>.<\/p>\n

Yoshiyuki Suzuki, Keiichi Moritoki, Mizuki Kajiwara, Ryo C. Yanagita*<\/strong>, Yasuhiro Kawanami, Yusuke Hanaki<\/strong>, Kazuhiro Irie.<\/p>\n

Biosci. Biotechnol. Biochem.<\/em> 2022<\/strong>, 86 (8), 1013-1023.<\/p>\n

 <\/p>\n

Analysis of binding mode of vibsanin A with protein kinase C C1 domeins: An experimental and molecular dynamics simulation study<\/a><\/strong>.<\/p>\n

Ryo C. Yanagita*<\/strong>, Mao Otani, Satoshi Hatanaka, Hiroto Nishi, Shota Miyake, Yusuke Hanaki<\/strong>, Masashi Sato, Yasuhiro Kawanami, Kazuhiro Irie.<\/p>\n

J. Mol. Struct.<\/em> 2022<\/strong>, 1260, 132866.<\/p>\n

 <\/p>\n

Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines<\/a><\/strong>.<\/p>\n

Yusuke Hanaki*<\/strong>, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita.<\/p>\n

Heterocycles<\/em> 2021<\/strong>, 102 (12), 2353-2362.<\/p>\n

 <\/p>\n

Evaluation of the <\/strong>in vitro<\/em><\/strong> cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions<\/strong><\/a>. \"\"<\/a><\/p>\n

Yusuke Hanaki*<\/strong>, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita.<\/p>\n

Fundam. Toxicol. Sci.<\/em> 2021<\/strong>, 8 (3), 69-73. \"\"<\/a><\/p>\n

 <\/p>\n

<\/h4>\n

 <\/p>\n

Before Kagawa Univ.<\/strong><\/h4>\n

 <\/p>\n

Stereodivergent Attached-Ring Synthesis via Non-Covalent Interactions: A Short Formal Synthesis of Merrilactone A<\/a><\/strong>.<\/p>\n

Benjamin J. Huffman, Tiffany Chu, Yusuke Hanaki<\/strong>, Jonathan Wong, Shuming Chen, Ken Houk, Ryan A. Shenvi*<\/strong>.<\/p>\n

Angew. Chem. Int. Ed.<\/em> 2022<\/strong>, 61 (3), e202114514.<\/p>\n

 <\/p>\n

Total synthesis and biological evaluation of oscillatoxins D, E, and F<\/a><\/strong>.<\/p>\n

Yusuke Araki\u2020<\/sup>, Yusuke Hanaki<\/strong>\u2020<\/sup> (\u2020<\/sup>equal contribution), Masaki Kita, Koutaro Hayakawa, Kazuhiro Irie, Yoshihiko Nokura, Atsuo Nakazaki, Toshio Nishikawa*<\/strong>.<\/p>\n

Biosci. Biotechnol. Biochem<\/em>. 2021<\/strong>, 85 (6), 1371-1382.<\/p>\n

 <\/p>\n

Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, a Potential Anti-Cancer Lead Derived from Debromoaplysiatoxin<\/a><\/strong>.<\/p>\n

Koutaro Hayakawa, Yusuke Hanaki<\/strong>, Harukuni Tokuda, Ryo C. Yanagita, Yu Nakagawa, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie*<\/strong>.<\/p>\n

Heterocycles<\/em> 2018<\/strong>, 97 (1), 478-492.<\/p>\n

 <\/p>\n

Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines<\/a><\/strong>.<\/p>\n

Yusuke Hanaki<\/strong>, Yuki Shikata, Masayuki Kikumori, Natsuki Hotta, Masaya Imoto, Kazuhiro Irie*<\/strong>.<\/p>\n

Biochem.<\/em> Biophys. Res. Commun.<\/em> 2018<\/strong>, 495 (1), 438-445.<\/p>\n

 <\/p>\n

Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-Aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities<\/a><\/strong>.<\/p>\n

Yusuke Hanaki<\/strong>, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie*<\/strong>.<\/p>\n

Molecules<\/em> 2017<\/strong>, 22 (4), 631.<\/p>\n

 <\/p>\n

Synthetic Models of Quasi-Stable Amyloid \u03b240 Oligomers with Significant Neurotoxicity<\/a><\/strong>.<\/p>\n

Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki<\/strong>, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-ichi Akagi, Kazuhiro Irie*<\/strong>.<\/p>\n

ACS Chem. Neurosci.<\/em> 2017<\/strong>, 8 (4), 807-816.<\/p>\n

 <\/p>\n

Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities<\/a><\/strong>.<\/p>\n

Yusuke Hanaki<\/strong>, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*<\/strong>.<\/p>\n

Biosci. Biotechnol. Biochem.<\/em> 2015<\/strong>, 79 (6), 888-895.<\/p>\n

 <\/p>\n

Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea Producens<\/a><\/strong>.<\/p>\n

Weina Jiang, Satoshi Tan, Yusuke Hanaki<\/strong>, Kazuhiro Irie, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai*<\/strong>.<\/p>\n

Marine Drugs<\/em> 2014<\/strong>, 12 (12), 5788-5800.<\/p>\n

 <\/p>\n

Structure\u2013activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity<\/a><\/strong>.<\/p>\n

Yusuke Hanaki<\/strong>, Masayuki Kikumori, Sayo Ueno, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*<\/strong>.<\/p>\n

T<\/em>etrahedron<\/em> 2013<\/strong>, 69 (36), 7636-7645.<\/p>\n","protected":false},"excerpt":{"rendered":"

Peer-Reviewed Papers \uff08Bold : Lab member,\u00a0 * Corres …<\/p>\n","protected":false},"author":1,"featured_media":145,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"spay_email":""},"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=\/wp\/v2\/pages\/88"}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=88"}],"version-history":[{"count":269,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=\/wp\/v2\/pages\/88\/revisions"}],"predecessor-version":[{"id":924,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=\/wp\/v2\/pages\/88\/revisions\/924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=\/wp\/v2\/media\/145"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/hanaki\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=88"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}