{"id":136,"date":"2023-09-29T16:14:42","date_gmt":"2023-09-29T07:14:42","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/hara\/?page_id=136"},"modified":"2026-04-26T13:13:30","modified_gmt":"2026-04-26T04:13:30","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/www.ag.kagawa-u.ac.jp\/hara\/%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be\/","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"\n
\u539f\u8457\u8ad6\u6587\uff08Original articles\uff09<\/h5>\n\n\n\n
[bold<\/strong>: Lab member]

Hara Y.<\/strong>*; Matsuoka Y.; Takaya A.; Ishibashi M.
Two new mycobactins, mycobactins U and V, and their ferric complexes isolated from Mycolicibacterium septicum<\/em> IFM 12283<\/a>
J. Nat. Med.<\/em> 80, 439-444 (2026). (shared https:\/\/rdcu.be\/e2biU<\/a>)

Lu Y.; Seto Y.; Hara Y.<\/strong>; Takaya A.; Uchida M.; Kusuya Y.; Ishibashi M.; Nakamura Y.; Takahashi H.
Comparative genomics of Nocardia tsunamiensis<\/em> IFM 10818, a new source of the antibacterial macrolide nargenicin A1<\/a>
Microbiol. Spectr.<\/em> 13, e01220-25 (2025).

Ujie Y.; Saito S.; Iwata C.; Kuwahara R.; Kishimoto S., Watanabe K.; Goto Y.; Ogawa K.; Hara Y.<\/strong>; Kusuya Y.; Takahashi H.; Yaguchi T.; Ishibashi M.; Arai M. A.
Host\u2013Pathogen Interaction Activated Biosynthesis of Natural Products<\/a>
J. Nat. Prod.<\/em> 88, 2204-2215 (2025).

Hara Y.<\/strong>*; Nakamura A.; Manome T.; Takaya A.; Takahashi H.; Ban S.; Yaguchi T.; Ishibashi M.
A new diterpenoid, carneadiol, isolated from Nocardia carnea <\/em>IFM 12324<\/a>
J. Nat. Med.<\/em> 79, 435-440 (2025).

Hanaki Y.; Hara Y.<\/strong>; Mori M.<\/strong>; Tomiyoshi K.
Identification of lotus cultivar-specific rhizome compounds and evaluation of their growth inhibitory activity against Fusarium commune<\/em><\/a>
Fundam. Toxicol. Sci.<\/em> 12(1), 1-5 (2025).

Hanaki Y.; Abe R.; Sugiyama Y.; Hara Y.<\/strong>; Yanagita R. C.
A new labdane-type diterpenoid from leaves of Vitex rotundifolia<\/em><\/a>
Results Chem.<\/em> 7, 101512 (2024).

Yamaguchi J.; Manome T.; Hara Y.<\/strong>; Yamazaki Y.; Nakamura Y.; Ishibashi M.; Takaya A.
Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus<\/em> by binding to AgrA<\/a>
Front. Pharmacol.<\/em> 15, 1365815 (2024).

Fujii K.; Iwata I.; Takaya A.; Ishibashi M.; Hara Y.<\/strong>*
New biflavonoids isolated from Xylia kerrii<\/em> leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells<\/a>
J. Nat. Med.<\/em> 78(3), 732-740 (2024).(https:\/\/rdcu.be\/dEhFu<\/a>)

Rakhi S. A.; Hara Y.<\/strong>; Islam M. S.; Manome T.; Alam S.; Emon N. U.; Al-Mansur M. A., Kuddus M. R.; Sarkar M. R.; Ishibashi M.; Ahmed F.
Isolation of bioactive phytochemicals from Crinum asiaticum<\/em> L. along with their cytotoxic and TRAIL-resistance abrogating prospect assessment<\/a>
Heliyon<\/em>, 10(3), e25049 (2023).

Ito T.; Hara Y<\/strong>.; Fukaya M.; Ryu K.; Iinuma M.
Resveratrol tetramer vaticanol N with a tribenzobicyclo[3.3.2]decatriene skeleton isolated from the leaves of Vatica bantamensis<\/em><\/a>
Phytochem. Lett.<\/em> 57, 16-21 (2023).<\/h6>\n\n\n\n
Hara Y.<\/strong>*; Manome T.; Suehiro W.; Harada S.; Yamagishi Y.; Takaya A.; Ogra Y.; Ishibashi M.
Isolation of two new trichorzin PA derivatives, trichorzin PA X and XI, from the terrestrial fungus Trichoderma harzianum<\/em> IFM 66736<\/a>
Tetrahedron Lett.<\/em> 121, 15488 (2023).<\/h6>\n\n\n\n
Manome T.; Hara Y.<\/strong>*; Ishibashi M.
Isolation of various flavonoids with TRAIL resistance-overcoming activity from Blumea lacera<\/em><\/a>
Molecules<\/em> 28(1), 264-264 (2023).<\/h6>\n\n\n\n
Manome T.; Hara Y.<\/strong>*; Ishibashi M.
A new 1,2-diketone physalin isolated from Physalis minima<\/em> and TRAIL-resistance overcoming activity of physalins<\/a>
J. Nat. Med. <\/em>77 (2), 370-378 (2023).<\/h6>\n\n\n\n
Fujii, K.; Hara, Y.<\/strong>*; Arai, M.A.; Sadhu, S.K.; Ahmed, F.; Ishibashi, M.
Natural compounds with BMI1 promoter inhibitory activity from Mammea siamensis<\/em> and Andrographis paniculata<\/em><\/a>
Chem. Pharm. Bull.<\/em> 70 (12), 885-891 (2022).<\/h6>\n\n\n\n
Jitrangsri, K.; Hara, Y.<\/strong>*; Takaya, A.; Ishibashi, M.
New polyoxygenated cyclohexenes isolated from Uvaria rufa<\/em> and cinnamtannin B1 isolated from Nephelium hypoleucum<\/em> with TRAIL-resistance-overcoming activity<\/a>
Phytochem. Lett.<\/em> 52, 7-9 (2022).<\/h6>\n\n\n\n
Hara, Y.<\/strong>*; Watanabe, K.; Takaya, A.; Ebihara, I.; Manome, T.; Arai, M.A.; Yaguchi, T.; Ishibashi, M.
Two bioactive compounds, uniformides A and B, isolated from a culture of Nocardia uniformis<\/em> IFM0856T<\/sup> in the presence of animal cells<\/a>
Org. Lett.<\/em> 24 (27), 4998-5002 (2022); Correction: 24 (31), 5867 (2022).<\/h6>\n\n\n\n
Manome, T.; Hara, Y.<\/strong>*; Ahmed, F.; Sadhu, S.K.; Ishibashi, M.
Thannilignan glucoside and 2-(\u03b2-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica<\/em><\/a>
J. Nat. Med. <\/em>76 (2), 482-489 (2022).<\/h6>\n\n\n\n
Hara, Y.<\/strong>*; Chiba, M.; Watanabe, K.; Ishibashi, M.
Isolation of ikahonone, 4-methyl-2,4-dihydroxy-3-pentanone from Bacillus cereus<\/em> IFM12235<\/a>
Heterocycles<\/em> 105 (1), 523-531 (2022).<\/h6>\n\n\n\n
Hara, Y.<\/strong>*; Tanimura, D.; Manome, T.; Arai, M.A.; Yaguchi, T.; Ishibashi, M.
Isolation of peptidolipin NA derivatives from the culture of Nocardia arthiritidis<\/em> IFM10035T<\/sup> in the presence of mouse macrophage cells<\/a>
Heterocycles<\/em> 104 (1), 185-190 (2022).<\/h6>\n\n\n\n
Jitrangsri, K.; Takaya, A.; Hara, Y.<\/strong>; Sadhu, S.K.; Ahmed, F.; Ishibashi, M.
Bioactivity-guided isolation of TRAIL-resistance overcoming activity compounds from the leaves of Murraya exotica<\/em><\/a>
Nat. Prod. Commun<\/em>. 16 (12), 1934578X211065843 (2021). <\/h6>\n\n\n\n
Arai, M.A.; Sakuraba, K.; Makita, Y.; Hara, Y.<\/strong>; Ishibashi, M.
Evaluation of naturally occurring HIF-1 inhibitors for pulmonary arterial hypertension<\/a>
ChemBioChem<\/em> 22, 2799-2804 (2021).<\/h6>\n\n\n\n
Ohizumi, Y.; Kawada, M.; Kamada, M.; Nakajima, A.; Kajima, K.; Uozumi, N.; Hara, Y<\/strong>.; Guo, Y.; Ishibashi, M.
Isolation of adenosine and cordysinin B from Anredera cordifolia<\/em> that stimulates CRE-mediated transcription in PC12 cells<\/a>
Planta Med. Int.<\/em> Open<\/em> 8 (01), e19-e24 (2021).<\/h6>\n\n\n\n
Arai, M.A.; Ebihara, I.; Makita, Y.; Hara, Y.<\/strong>; Yaguchi, T.; Ishibashi, M.
Isolation of nocobactin NAs as Notch signal inhibitors from Nocardia farcinica<\/em>, a possibility of invasive evolution<\/a>
J. Antibiot.<\/em> 74 (4), 255-259 (2021).<\/h6>\n\n\n\n
Hara, Y.<\/strong>; Totsugi, Y.; Ichikawa, H.; Harada, S.; Fujii, K.; Ahmed, F.; Sadhu, S.K.; Arai, M.A.; Ishibashi, M.
Acacienone, a terpenoid\u2011like natural product having an unprecedented C20 framework isolated from Acacia mangium<\/em> leaves<\/a>
J. Nat. Med.<\/em> <\/strong>75 (1), 99-104 (2021).<\/h6>\n\n\n\n
Sakai, K.; Hara, Y.<\/strong>; Ishibashi, M.; Sakai, M.; Kawahara, S.; Imanishi, S.; Harada, K.; Hoshino, Y.; Komaki, H.; Mukai, A.; Gonoi, T.
Characterization of nocardithiocin derivatives produced by amino acid substitution of precursor peptide notG<\/a>
Int. J. Pept. Res. Ther.<\/em> 26, 281-290 (2020).<\/h6>\n\n\n\n
Sato, T.; Arai, M.A.; Yixizhuoma; Hara, Y.<\/strong>; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
Cadinane sesquiterpenoids isolated from Santalum album<\/em> using a screening program for Wnt signal inhibitory activity<\/a>
J. Nat. Med. <\/em>74 (2), 476-481 (2020).<\/h6>\n\n\n\n
Jomori, T.; Hara, Y.<\/strong>; Sasaoka, M.; Harada, K.; Setiawan, A.; Hirata, K.; Kimishima, A.; Arai, M.
Mycobacterium smegmatis<\/em> alters the production of secondary metabolites by marine-derived Aspergillus niger<\/em><\/a>
J. Nat. Med.<\/em> 74 (1), 76-82 (2020).<\/h6>\n\n\n\n
Kobayashi, N.; Hara, Y.<\/strong>; Arai, M.A.; Hara, S.; Gonoi, T.; Yaguchi, T.; Ishibashi, M.
Isolation of inohanalactone, a \u03b3-butyrolactone, from Nocardia inohanensis<\/em> IFM0092T<\/sup><\/a>
Heterocycles<\/em> 101 (1), 312-317 (2020).<\/h6>\n\n\n\n
Yokoyama, Y.; Arai, M.A.; Hara, Y.<\/strong>; Ishibashi, M.
Nonactic acid derivatives isolated from Streptomyces werraensis<\/em> IFM12104 in a screening program for BMI1 promoter inhibitory activity<\/a>
Nat. Prod. Commun.<\/em> 14 (7), 1934578X1986658. (2019).<\/h6>\n\n\n\n
Yokoyama, Y.; Arai, M.A.; Hara, Y.<\/strong>; Ishibashi, M.
Identification of BMI1 promoter inhibitors from Streptomyces<\/em> sp. IFM-11958<\/a>
Bioorg. Med. Chem.<\/em>, 27 (13), 2998-3003 (2019).<\/h6>\n\n\n\n
Hara, S.; Hara, Y<\/strong>.; Arai, M.A.; Kusuya, Y.; Takahashi, H.; Yaguchi, T.; Ishibashi, M.
Isolation of nabscessin C from Nocardia abscessus<\/em> IFM 10029T<\/sup> and a study on biosynthetic pathway for nabscessins<\/a>
Chem. Pharm. Bull.<\/em> 66 (10), 976-982 (2018).<\/h6>\n\n\n\n
Hara, Y.<\/strong>; Arai, M.A.; Toume, K.; Masu, H.; Sato, T.; Komatsu, K.; Yaguchi, T.; Ishibashi, M.
Coculture of a pathogenic actinomycete and animal cells to produce nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect<\/a>
Org. Lett.<\/em> 20 (18), 5831-5834 (2018).<\/h6>\n\n\n\n
Hara, Y.<\/strong>; Arai, M.A.; Sakai, K.; Ishikawa, N.; Gonoi, T.; Yaguchi, T.; Ishibashi, M.
Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis<\/em> IFM 10554T<\/sup> in the presence of animal cells<\/a>
J. Nat. Med. <\/em>72 (1), 280-289 (2018).<\/h6>\n\n\n\n
Hara, S.; Ishikawa, N.; Hara, Y.<\/strong>; Nehira, T.; Sakai, K.; Gonoi, T.; Ishibashi, M.
Nabscessins A and B, aminocyclitol derivatives from Nocardia abscessus <\/em>IFM 10029T<\/sup><\/a>
J. Nat. Prod.<\/em> 80 (2), 565-568 (2017).<\/h6>\n\n\n\n
Ito, T.; Hara, Y.<\/strong>; Kubota, Y.; Sawa, R.; Iinuma, M.
Absolute structure of resveratrol hexamers in Dipterocarpaceaeous plants<\/a>
Tetrahedron<\/em> 72 (7), 891-899 (2016). <\/h6>\n\n\n\n
Ito, T.; Hoshino, R.; Hara, Y.<\/strong>; Oyama, M.; Iinuma, M.
Absolute configuration and conformational analysis of C<\/em>-glucoside of a resveratrol trimer: Structure of hopeaside E from Hopea utilis<\/em><\/a>
Phytochem. Lett.<\/em> 6 (2), 193-197 (2013). <\/h6>\n\n\n\n
Ito, T.; Hara, Y.<\/strong>; Oyama, M.; Tanaka, T.; Murata, J.; Darnaedi, D.; Iinuma, M.
Occurrence of bergenin phenylpropanoates in Vatica bantamensis<\/em><\/a>
Phytochem. Lett.<\/em> 5 (4), 743-746 (2012).<\/h6>\n\n\n\n
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\u7dcf\u8aac\uff08Reviews<\/span>\uff09<\/h5>\n\n\n\n
Hara Y.*<\/strong>
Search for natural products from actinomycetes of the genus Nocardia<\/em><\/a>
Journal of Natural Medicines<\/em>, 78 (4), 828-837 (2024).(invited)<\/strong><\/h6>\n\n\n\n
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\u7279\u8a31<\/strong>\uff08Patent\uff09<\/h5>\n\n\n\n
\u51fa\u9858\u756a\u53f7: \u7279\u98582016-120162
\u540d\u79f0: \u30ca\u30d6\u30bb\u30b7\u30f3A\u3001\u30ca\u30d6\u30bb\u30b7\u30f3B\u3001\u53ca\u3073\u305d\u306e\u88fd\u9020\u65b9\u6cd5
\u767a\u660e\u8005: \u77f3\u6a4b\u6b63\u5df1\u30fb\u539f\u6607\u5b50\u30fb\u539f\u5eb7\u96c5\u30fb\u77f3\u5ddd\u76f4\u6a39\u30fb\u9152\u4e95\u9999\u5948\u6c5f\u30fb\u4e94\u30ce\u4e95\u900f
\u51fa\u9858\u4eba: \u5343\u8449\u5927\u5b66\u3000\u51fa\u9858\u65e5:2016.6.16
\u516c\u958b\u756a\u53f7: \u7279\u958b2017-222617\u3000\u516c\u958b\u65e5:2017.12.21<\/h6>\n\n\n\n
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\u8457\u66f8\u53ca\u3073\u305d\u306e\u4ed6\uff08Books and Others<\/span>\uff09<\/h5>\n\n\n\n
\u539f\u5eb7\u96c5
\u300c\u30b2\u30ce\u30e0\u89e3\u6790\u3088\u308a\u898b\u3044\u3060\u3055\u308c\u305f\u30da\u30d7\u30c1\u30c9\u306fCa2+<\/sup>\u4f9d\u5b58\u6027\u6297\u751f\u7269\u8cea\u958b\u62d3\u306b\u7e4b\u304c\u308b\u304b\uff1f\u300d<\/a>
\u30d5\u30a1\u30eb\u30de\u30b7\u30a2<\/em>, 61 (1), 68 (2025). (invited<\/strong>)

interviewee: \u539f\u5eb7\u96c5
\u751f\u7269\u304c\u5275\u308a\u51fa\u3059\u672a\u77e5\u306e\u5929\u7136\u7269\u3084\u6709\u7528\u306a\u5929\u7136\u7269\u3092\u3055\u304c\u3059\uff01
\u9999\u5ddd\u5927\u5b66\u8fb2\u5b66\u90e8 \u300c\u9ad8\u6821\u751f\u306e\u305f\u3081\u306e\u6ce8\u76ee\u306e\u7814\u7a76\u8005\u30fb\u7814\u7a76\u30df\u30cb\u89e3\u8aac\u7b2c13\u56de\u300d 2024\u5e7412\u670823\u65e5 (\u8fb2\u5b66\u90e8HP<\/a>, Instagram<\/a>\u516c\u958b)

\u539f\u5eb7\u96c5
2022\u5e74\u5ea6\u732a\u4e4b\u9f3b\u5968\u5b66\u4f1a\u7814\u7a76\u52a9\u6210\u91d1\u7814\u7a76\u5831\u544a\u300c\u653e\u7dda\u83cc Nocardia<\/em> \u306e\u7523\u751f\u3059\u308b\u611f\u67d3\u5bbf\u4e3b\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u5bc4\u4e0e\u3059\u308b\u5929\u7136\u7269\u306e\u63a2\u7d22\u3068\u305d\u306e\u6a5f\u80fd\u89e3\u660e<\/a>\u300d
\u5343\u8449\u533b\u5b66<\/em>, 99 (6), 156-157 (2023).

\u539f\u5eb7\u96c5
\u9999\u5ddd\u5927\u5b66\u7814\u7a76\u30b7\u30fc\u30ba\u306e\u7d39\u4ecb\uff08\u7b2c101\u56de\uff09\u300c\u690d\u7269\u3084\u5fae\u751f\u7269\u304b\u3089\u306e\u5929\u7136\u7269\u63a2\u7d22\u300d
\u4e00\u822c\u8ca1\u56e3\u6cd5\u4eba\u767e\u5341\u56db\u7d4c\u6e08\u7814\u7a76\u6240: \u8abf\u67fb\u6708\u5831No.438, 2023\u5e749\u6708.

\u539f\u5eb7\u96c5
\u60c5\u5831\u30fb\u653f\u7b56\u30c8\u30d4\u30c3\u30af\u30b9\u300c\u690d\u7269\u3084\u5fae\u751f\u7269\u304b\u3089\u306e\u5929\u7136\u7269\u63a2\u7d22<\/a>\u300d
\u9999\u5ddd\u30cb\u30e5\u30fc\u30d3\u30b8\u30cd\u30b9\u30af\u30e9\u30d6\u4e8b\u52d9\u5c40: KNBC News No. 279, 2023\u5e749\u6708.

\u539f\u5eb7\u96c5
\u300cB. gladioli<\/em>\u83cc\u7531\u6765\u306e\u5929\u7136\u7269\u306f\u30b7\u30c7\u30ed\u30d5\u30a9\u30a2\u304b\uff1f<\/a>\u300d
\u5316\u5b66<\/em>, 76 (8), 62-63 (2021). (invited)<\/strong>

interviewee: \u539f\u5eb7\u96c5, \u77f3\u6a4b\u6b63\u5df1
\u300c\u83cc\u306e\u5316\u5408\u7269\u3000\u65b0\u63a2\u7d22\u6cd5\u300d
\u65e5\u7d4c\u7523\u696d\u65b0\u805e 2018\u5e743\u670828\u65e5.

\u539f\u5eb7\u96c5
\u300c\u653e\u7dda\u83cc\u306b\u52d5\u7269\u7d30\u80de\u3092\u6df7\u305c\u3066\u5f97\u305f\u65b0\u3057\u3044\u5316\u5408\u7269<\/a>\u300d
\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c138\u5e74\u4f1a (\u91d1\u6ca2) \u5831\u9053\u6a5f\u95a2\u5411\u3051\u8b1b\u6f14\u30cf\u30a4\u30e9\u30a4\u30c8, 2018, 30.

\u539f\u5eb7\u96c5
\u300c\u81e8\u5e8a\u5206\u96e2\u83cc\u304b\u3089\u5f97\u3089\u308c\u305f\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u306f\u591a\u5264\u8010\u6027\u7d50\u6838\u514b\u670d\u3078\u306e\u5e0c\u671b\u3068\u306a\u308b\u304b\uff1f<\/a>\u300d
\u30d5\u30a1\u30eb\u30de\u30b7\u30a2<\/em>, 54 (2), 165 (2018). (invited)<\/strong><\/h6>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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