{"id":62981,"date":"2026-07-16T10:31:24","date_gmt":"2026-07-16T01:31:24","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/?p=62981"},"modified":"2026-07-16T10:31:28","modified_gmt":"2026-07-16T01:31:28","slug":"contribution-of-polyphenols-in-wine-grape-extract-to-the-inhibition-of-serine-protease-activity-and-proteinase-activated-receptor-1-mediated-ca%c2%b2%e2%81%basignaling-in-vascular-endothelial-cells","status":"publish","type":"post","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?p=62981","title":{"rendered":"Contribution of polyphenols in wine grape extract to the inhibition of serine protease activity and proteinase-activated receptor 1-mediated Ca\u00b2\u207asignaling in vascular endothelial cells\uff08\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u3068\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\u6d3b\u6027\u5316\u53d7\u5bb9\u4f531\u3092\u4ecb\u3057\u305f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306eCa\u00b2\u207a \u30b7\u30b0\u30ca\u30eb\u306e\u963b\u5bb3\u306b\u5bfe\u3059\u308b\u30ef\u30a4\u30f3\u30d6\u30c9\u30a6\u62bd\u51fa\u6db2\u4e2d\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u5bc4\u4e0e\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u3000\u30ef\u30a4\u30f3\u7528\u30d6\u30c9\u30a6\u2018\u9999\u5927\u8fb2R-1\u2019 \u306f\u30c8\u30ab\u30e9\u5217\u5cf6\u4ee5\u5357\u306b\u81ea\u751f\u3059\u308b\u91ce\u751f\u7a2e\u30ea\u30e5\u30a6\u30ad\u30e5\u30a6\u30ac\u30cd\u30d6\uff08<em>Vitis ficifolia <\/em>var.<em> ganebu<\/em>\uff09\u3068\u683d\u57f9\u54c1\u7a2e\u2018\u30de\u30b9\u30ab\u30c3\u30c8\u30fb\u30aa\u30d6\u30fb\u30a2\u30ec\u30ad\u30b5\u30f3\u30c9\u30ea\u30a2\u2019\uff08<em>Vitis vinifera<\/em>\uff09\u306e\u4ea4\u96d1\u7a2e\u3067\u3042\u308b\u3002\u3053\u306e\u5ea6\u3001\u9999\u5ddd\u5927\u5b66\u8fb2\u5b66\u90e8\u9644\u5c5e\u8fb2\u5834\u3000\u671b\u5ca1\u4eae\u4ecb\u540d\u8a89\u6559\u6388\u3001\u8af8\u9688\u6b63\u88d5\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3068\u9999\u5ddd\u5927\u5b66\u533b\u5b66\u90e8\u81ea\u5f8b\u6a5f\u80fd\u751f\u7406\u5b66\u3000\u5e73\u91ce\u52dd\u4e5f\u540d\u8a89\u6559\u6388\uff08\u73fe\u798f\u5ca1\u6b6f\u79d1\u5927\u5b66\uff09\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001\u305d\u306e50\uff05\u30a8\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269\u306f\u3001\u30c8\u30ed\u30f3\u30d3\u30f3\u306a\u3069\u306e\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u3092\u975e\u7af6\u5408\u7684\u306b\u963b\u5bb3\u3057\u3001\u30d6\u30bf\u5927\u52d5\u8108\u5185\u76ae\u7d30\u80de\u306b\u304a\u3044\u3066\u30c8\u30ed\u30f3\u30d3\u30f3\u8a98\u767a\u306e\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u8840\u7ba1\u75be\u60a3\u306b\u95a2\u4e0e\u3059\u308b\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53<sub>1<\/sub>\uff08PAR<sub>1<\/sub>\uff09\u3092\u4ecb\u3057\u305f\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002\u6210\u5206\u5206\u6790\u306e\u7d50\u679c\u3001\u3053\u306e\u6291\u5236\u52b9\u679c\u306e\u7d04\u534a\u5206\u306f\u62bd\u51fa\u7269\u306b\u542b\u307e\u308c\u308b\u30ab\u30c6\u30ad\u30f3\u3084\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306a\u3069\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u985e\u306b\u8d77\u56e0\u3057\u3066\u304a\u308a\u3001\u8840\u7ba1\u75be\u60a3\u4e88\u9632\u306b\u5411\u3051\u305f\u5929\u7136\u6210\u5206\u6d3b\u7528\u306e\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u30012026\u5e747\u67082\u65e5Fitoterapia\u8a8c\u306b\u767a\u8868\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">URL\uff1a<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X26002868\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X26002868<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u30ef\u30a4\u30f3\u7528\u30d6\u30c9\u30a6\u2018\u9999\u5927\u8fb2R-1\u2019 \u306f\u30c8\u30ab\u30e9\u5217\u5cf6\u4ee5\u5357\u306b\u81ea\u751f\u3059\u308b\u91ce\u751f\u7a2e\u30ea\u30e5\u30a6\u30ad\u30e5\u30a6\u30ac &hellip; 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