{"id":1946,"date":"2012-01-17T17:47:28","date_gmt":"2012-01-17T08:47:28","guid":{"rendered":"http:\/\/www.ag.kagawa-u.ac.jp?post_type=research&p=1946"},"modified":"2024-05-09T13:25:29","modified_gmt":"2024-05-09T04:25:29","slug":"%e4%bd%90%e8%97%a4%e6%ad%a3%e8%b3%87%e3%80%80%ef%bc%88%e7%94%9f%e7%89%a9%e6%b4%bb%e6%80%a7%e5%a4%a9%e7%84%b6%e7%89%a9%e5%8c%96%e5%ad%a6%ef%bc%89","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e4%bd%90%e8%97%a4%e6%ad%a3%e8%b3%87%e3%80%80%ef%bc%88%e7%94%9f%e7%89%a9%e6%b4%bb%e6%80%a7%e5%a4%a9%e7%84%b6%e7%89%a9%e5%8c%96%e5%ad%a6%ef%bc%89","title":{"rendered":"\u4f50\u85e4\u3000\u6b63\u8cc7"},"content":{"rendered":"
\n
\n
\n
\u65e5\u672c\u8a9e<\/div><\/div>
\n
English<\/div><\/div><\/div><\/div>\n
\n\n
\n
\n
\n
\n

\u9818\u3000\u57df\u3000\u540d\u3000\u3000\u751f\u7269\u5206\u5b50\u5316\u5b66<\/mark><\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000\u3000 \u4f50\u3000\u85e4\u3000\u6b63\u3000\u8cc7<\/mark><\/strong><\/h2>\n<\/div>\n\n\n\n
\n

\u7814\u7a76\u5206\u91ce\u3000\u751f\u7269\u6d3b\u6027\u5929\u7136\u7269\u5316\u5b66<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u3000\u751f\u7269\u6d3b\u6027\u7269\u8cea\uff0c\u7dda\u866b\uff0c\u5e0c\u5c11\u7cd6\uff0c\u6297\u8001\u5316<\/strong><\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c<\/strong><\/h2>\n\n\n\n
\n
\n

\uff11\uff0e\u6297\u8001\u5316\u52b9\u679c\u3092\u3082\u3064\u5e0c\u5c11\u7cd6\u306e\u63a2\u7d22<\/strong><\/h2>\n\n\n\n

\u6442\u53d6\u30ab\u30ed\u30ea\u30fc\u306e\u5236\u9650\u306f\uff0c\u69d8\u3005\u306a\u5b9f\u9a13\u52d5\u7269\u306e\u5bff\u547d\u3092\u5ef6\u9577\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082\uff0c\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306f\u7cd6\u5c3f\u75c5\uff0c\u764c\u306a\u3069\u52a0\u9f62\u6027\u75be\u60a3\u306e\u767a\u75c7\u3092\u9045\u3089\u305b\uff0c\u305d\u306e\u7d50\u679c\uff0c\u5bff\u547d\u3092\u5ef6\u9577\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\uff0c\u4ee3\u8b1d\u6291\u5236\u52b9\u679c\u3092\u3082\u3064\u5e0c\u5c11\u7cd6\u304c\u4f53\u5185\u3092\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u72b6\u614b\u306b\u3057\u3066\uff0c\u52d5\u7269\u306e\u5bff\u547d\u3092\u5ef6\u9577\u3059\u308b\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u305f\u3002\u8001\u5316\u7814\u7a76\u306e\u30e2\u30c7\u30eb\u751f\u7269\u3067\u3042\u308b\u7dda\u866bC.elegans<\/em>\u3092\u7528\u3044\u3066\u7814\u7a76\u3092\u884c\u3044\uff0c\u5e0c\u5c11\u7cd6 D-\u30d7\u30b7\u30b3\u30fc\u30b9\uff08D-\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u306e\u7570\u6027\u4f53\uff09\u306e\u5bff\u547d\u5ef6\u9577\u52b9\u679c\u3092\u5831\u544a\u3057\u305f\u3002\u73fe\u5728\uff0c50\u7a2e\u985e\u4ee5\u4e0a\u306e\u5e0c\u5c11\u7cd6\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u306e\u4e2d\u304b\u3089\u65b0\u305f\u306a\u6297\u8001\u5316\u5e0c\u5c11\u7cd6\u3092\u63a2\u7d22\u3059\u308b\u3053\u3068\uff0c\u307e\u305f\uff0c\u591a\u6570\u306e\u8a66\u6599\u306e\u4e2d\u304b\u3089\uff0c\u7c21\u4fbf\u30fb\u8fc5\u901f\u306b\u6d3b\u6027\u7269\u8cea\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6cd5\u3092\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
\n
\n

\uff12\uff0e\u5e0c\u5c11\u7cd6\u6297\u8001\u5316\u52b9\u679c\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e<\/strong><\/h2>\n\n\n\n

\u751f\u5316\u5b66\uff0c\u5206\u5b50\u751f\u7269\u5b66\u306e\u624b\u6cd5\uff0c\u307e\u305f\uff0c\u8a98\u5c0e\u4f53\u5408\u6210\u306a\u3069\u306e\u751f\u7269\u6709\u6a5f\u5316\u5b66\u7684\u624b\u6cd5\u3092\u7528\u3044\u3066\u5e0c\u5c11\u7cd6\u6297\u8001\u5316\u52b9\u679c\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002<\/p>\n\n\n\n

\uff13\uff0e\u7dda\u866b\u3092\u7528\u3044\u305f\u69d8\u3005\u306a\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u63a2\u7d22<\/strong><\/h2>\n\n\n\n

\u57f9\u990a\u3084\u89b3\u5bdf\u304c\u5bb9\u6613\u306aC.elegans<\/em>\u306f\u751f\u7269\u6d3b\u6027\u7269\u8cea\u63a2\u7d22\u306e\u30d7\u30ed\u30fc\u30d6\uff08\u63a2\u308a\u91dd\uff09\u3068\u306a\u308a\u5f97\u308b\u3002\u3053\u308c\u3092\u7528\u3044\u3066\u5e0c\u5c11\u7cd6\u304b\u3089\u306e\u6297\u7dda\u866b\u6d3b\u6027\u7269\u8cea\u3084\u6297\u80a5\u6e80\u7269\u8cea\u306a\u3069\u306e\u63a2\u7d22\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
\n

\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/h2>\n<\/div>
\"\"<\/figure><\/div>\n\n\n\n
    \n
  • Sato, M. et al.: Potential anthelmintic: D-psicose inhibits motility, growth and reproductive maturity of L1 larvae of Caenorhabditiselegans<\/em>. J. Nat. Med.,62, 244-246, (2008).<\/li>\n\n\n\n
  • Sato, M. et al.: D-Ribose competitively reverses inhibition by D-psicose of Larval growth in Caenorhabditiselegans<\/em>. Biological and Pharmaceutical Bulletin 32, 950-952 (2009) .<\/li>\n\n\n\n
  • Sato, M., et al.: Structural characteristics for superoxide anion radical scavenging and productive activities of green tea polyphenols including proanthocyanidin dimers. Chemical and Pharmaceutical Bulletin 58, 98-102 (2010).<\/li>\n\n\n\n
  • \u65b0\u8c37\u77e5\u4e5f\u4ed6\uff1a \u30ab\u30ed\u30ea\u30fc\u5236\u9650\u6a21\u5023\u7269\u8cea\u3068\u3057\u3066\u306e\u5e0c\u5c11\u7cd6D-\u30d7\u30b7\u30b3\u30fc\u30b9\u53ca\u3073D-\u30a2\u30ed\u30fc\u30b9 \uff0d\u6297\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u52b9\u679c\u304b\u3089\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u3078\uff0d\uff0c\u65e5\u672c\u91b8\u9020\u5354\u4f1a\u8a8c108\uff0c565-574\uff082013\uff09<\/li>\n\n\n\n
  • Sakoguchi, H. et al.: Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans<\/em>: Discovery of a novel bioactive monosaccharide, Bioorg. Med. Chem. Lett., 26 726-729 (2016).<\/li>\n\n\n\n
  • Sakoguchi, H. et al.: Screening of biologically active monosaccharides: growth inhibitory effects of D-allose, D-talose, and L-idose against the nematode Caenorhabditis elegans<\/em>, Biosci. Biotechnol. Biochem., 80 1058-1061 (2016).<\/li>\n<\/ul>\n\n\n\n

    <\/p>\n\n<\/div>

    \n\n
    \n
    \n

    Research Area:\u3000Biological Molecular Chemistry<\/mark><\/strong><\/h2>\n\n\n\n

    Research<\/strong> Specialization:\u3000Bioactive Natural Products Chemistry<\/mark><\/strong><\/h2>\n\n\n\n

    Name:\u3000SATO, Masashi<\/mark><\/strong><\/h2>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    Keywords\uff1a Biologically active substance, C. elegans<\/em>, Rare sugar, Anti-aging<\/strong><\/p>\n<\/div>\n\n\n\n

    \n
    \"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

    Recent Research<\/strong><\/strong><\/h2>\n\n\n\n
    \n
    \n

    1.\u3000Exploration of anti-aging rare sugars\u3000<\/strong><\/strong><\/h2>\n\n\n\n

       Restriction of calorie intake is known to prolong the life span of various experimental animals. Even in humans, calorie restriction retards the onset of age-related diseases such as diabetes and cancer, and as a result it is thought to prolong life span. We thought that rare sugars having a metabolic suppression effect would make the body calorie restricted and prolong the life of the animal. We conducted the research using the nematode Caenorhabditis elegans<\/em>, a model animal of aging research, and have reported that the rare sugar D-allulose (a stereoisomer of D-fructose) extended the lifespan of C. elegans<\/em>. Currently, we are working on searching for novel anti-aging substances from over 50 kinds of rare sugars and their derivatives, and are developing screening methods to find active substances conveniently and quickly.<\/p>\n<\/div>\n\n\n\n

    \n
    \"\"<\/figure>\n\n\n\n
    \"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
    \n
    \n

    2.\u3000Mechanism of the anti-aging effect of rare sugars\u3000<\/strong><\/strong><\/h2>\n\n\n\n

    \u3000We are working on elucidating the mechanism of action of rare sugar anti-aging effect by biochemical, molecular biological techniques, and bio-organic chemical approaches such as derivatives synthesis.<\/p>\n<\/div>\n\n\n\n

    \n
    \"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
    \n

    Publications<\/strong><\/h2>\n<\/div>
    \"\"<\/figure><\/div>\n\n\n\n
      \n
    • Sato, M. et al.: Potential anthelmintic: D-psicose inhibits motility, growth and reproductive maturity of L1 larvae of Caenorhabditis elegans<\/em>. J. Nat. Med.,62, 244-246, (2008).<\/li>\n\n\n\n
    • Sato, M. et al.: D-Ribose competitively reverses inhibition by D-psicose of Larval growth in Caenorhabditiselegans<\/em>. Biological and Pharmaceutical Bulletin 32, 950-952 (2009) .<\/li>\n\n\n\n
    • Sato, M., et al.: Structural characteristics for superoxide anion radical scavenging and productive activities of green tea polyphenols including proanthocyanidin dimers. Chemical and Pharmaceutical Bulletin 58, 98-102 (2010).<\/li>\n\n\n\n
    • Sakoguchi, H. et al.: Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans<\/em>: Discovery of a novel bioactive monosaccharide, Bioorg. Med. Chem. Lett., 26 726-729 (2016).<\/li>\n\n\n\n
    • Sakoguchi, H. et al.: Screening of biologically active monosaccharides: growth inhibitory effects of D-allose, D-talose, and L-idose against the nematode Caenorhabditis elegans<\/em>, Biosci. Biotechnol. Biochem., 80 1058-1061 (2016).<\/li>\n<\/ul>\n\n\n\n

      <\/p>\n\n<\/div><\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":15798,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","ub_ctt_via":"","footnotes":""},"class_list":["post-1946","research","type-research","status-publish","has-post-thumbnail","hentry","research_keyword-_","research_keyword-135","research_keyword-281","research_keyword-282","research_category-124","center_category-258","center_category-260","sdgs_category-6","sdgs_category-12"],"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/1946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1946"}],"version-history":[{"count":44,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/1946\/revisions"}],"predecessor-version":[{"id":32761,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/1946\/revisions\/32761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/15798"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}