{"id":2182,"date":"2012-01-18T11:29:28","date_gmt":"2012-01-18T02:29:28","guid":{"rendered":"http:\/\/www.ag.kagawa-u.ac.jp?post_type=research&p=2182"},"modified":"2026-04-02T08:59:44","modified_gmt":"2026-04-01T23:59:44","slug":"%e6%9f%b3%e7%94%b0-%e4%ba%ae-%ef%bc%88%e3%82%b1%e3%83%9f%e3%82%ab%e3%83%ab%e3%83%90%e3%82%a4%e3%82%aa%e3%83%ad%e3%82%b8%e3%83%bc%ef%bc%89","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e6%9f%b3%e7%94%b0-%e4%ba%ae-%ef%bc%88%e3%82%b1%e3%83%9f%e3%82%ab%e3%83%ab%e3%83%90%e3%82%a4%e3%82%aa%e3%83%ad%e3%82%b8%e3%83%bc%ef%bc%89","title":{"rendered":"\u6801\u7530\u3000\u4eae"},"content":{"rendered":"
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\u65e5\u672c\u8a9e<\/div><\/div>
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English<\/div><\/div><\/div><\/div>\n
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\u9818\u57df\u540d \u751f\u7269\u5206\u5b50\u5316\u5b66<\/mark>   <\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000 \u67f3\u3000\u7530\u3000\u3000\u4eae<\/mark><\/strong><\/h2>\n<\/div>\n\n\n\n
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\u7814\u7a76\u5206\u91ce \u30b1\u30df\u30ab\u30eb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
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\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u5929\u7136\u7269\uff0c\u767a\u304c\u3093\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\uff0c\u30a2\u30ca\u30ed\u30b0\u5408\u6210<\/strong><\/p>\n\n\n\n

\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c<\/strong><\/h2>\n<\/div>\n\n\n\n
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1. \u65b0\u898f\u6a5f\u80fd\u6027\u3092\u6301\u3064\u767a\u304c\u3093\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u30a2\u30ca\u30ed\u30b0\u306e\u958b\u767a<\/strong><\/h2>\n\n\n\n
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\u3000\u767a\u304c\u3093\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3068\u306f\uff0c\u6f5c\u5728\u7684\u816b\u760d\u7d30\u80de\u3092\u30af\u30ed\u30fc\u30ca\u30eb\u306b\u5897\u6b96\u3055\u305b\u816b\u760d\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u5316\u5408\u7269\u306e\u7dcf\u79f0\u3067\u3042\u308b\uff0e\u6700\u8fd1\uff0c\u5929\u7136\u306e\u767a\u304c\u3093\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u69cb\u9020\u3092\u6539\u5909\u3059\u308b\u3053\u3068\u3067\uff0c\u671b\u307e\u3057\u3044\u6a5f\u80fd\u6027\u3092\u6301\u3064\u65b0\u898f\u30a2\u30ca\u30ed\u30b0\u306e\u958b\u767a\u304c\u884c\u308f\u308c\u3066\u3044\u308b\uff0e\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u6297\u816b\u760d\u6027\u5316\u5408\u7269\u3084\u304c\u3093\u5316\u6a5f\u69cb\u3092\u63a2\u308b\u30c4\u30fc\u30eb\u306e\u5275\u88fd\u3092\u76ee\u6307\u3057\u3066\uff0c\u30a2\u30e1\u30d5\u30e9\u30b7\u7531\u6765\u306e\u30a2\u30d7\u30ea\u30b7\u30a2\u30c8\u30ad\u30b7\u30f3\u3084\u30bb\u30ea\u79d1\u690d\u7269\u7531\u6765\u306e\u30bf\u30d7\u30b7\u30ac\u30eb\u30ae\u30f3\u3068\u3044\u3063\u305f\u5929\u7136\u767a\u304c\u3093\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u5358\u7d14\u5316\u30a2\u30ca\u30ed\u30b0\u306e\u958b\u767a\u3092\u884c\u3063\u3066\u3044\u308b<\/p>\n<\/div>\n\n\n\n

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2. \u6297\u816b\u760d\u6027\u3092\u793a\u3059\u65b0\u898f\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc C \u30ea\u30ac\u30f3\u30c9\u306e\u63a2\u7d22<\/strong><\/h2>\n\n\n\n
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\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcC (PKC) \u306f\uff0c\u304c\u3093\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff0cHIV \u6cbb\u7642\u85ac\u306e\u6a19\u7684\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u5408\u6210 PKC C1\u30da\u30d7\u30c1\u30c9\u3092\u4f7f\u3063\u3066\uff0c\u69d8\u3005\u306a\u690d\u7269\u30bd\u30fc\u30b9\u304b\u3089\u65b0\u898f PKC \u6d3b\u6027\u5316\u5264\u306e\u63a2\u7d22\u3092\u884c\u3063\u3066\u3044\u308b\uff0e<\/p>\n<\/div>\n\n\n\n

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3. \u5e0c\u5c11\u7cd6\u3092\u57fa\u306b\u3057\u305f\u65b0\u898f\u6a5f\u80fd\u6027\u5206\u5b50\u306e\u958b\u767a<\/strong><\/h2>\n\n\n\n

\u3000\u5929\u7136\u306b\u7a00\u306b\u3057\u304b\u5b58\u5728\u3057\u306a\u3044\u5358\u7cd6\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u306e\u4e2d\u306b\u306f\uff0c\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308b\u5897\u6b96\u6291\u5236\u6d3b\u6027\u306a\u3069\u6709\u7528\u306a\u751f\u7269\u6d3b\u6027\u3092\u793a\u3059\u3082\u306e\u304c\u3042\u308b\u3053\u3068\u304c\u3053\u308c\u307e\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u5e0c\u5c11\u7cd6\u306e\u8a98\u5c0e\u4f53\u5316\u306b\u3088\u308b\u304c\u3093\u7d30\u80de\u5897\u6b96\u6291\u5236\u6d3b\u6027\u306e\u5411\u4e0a\uff0c\u5206\u5b50\u30d7\u30ed\u30fc\u30d6\u5316\u306b\u3088\u308b\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

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\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>

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  • Ueno, S., et al. <\/em>Identification and Biological Activities of Bryostatins from Japanese Bryozoan. Biosci. Biotechnol. Biochem. <\/em>2012<\/strong>, 76<\/em>, 1041\u20131043.<\/li>\n\n\n\n
  • Yanagita, R. C., et al. <\/em>Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities. Bioorg. Med. Chem. Lett<\/em>. 2013<\/strong>, 23<\/em>, 4319\u20134323.<\/li>\n\n\n\n
  • Yanagita, R. C., et al. <\/em>Anti-proliferative activity of 6-O<\/em>-acyl-D-allose against the human leukemia MOLT-4F cell line. Biosci. Biotechnol. Biochem. <\/em>2014<\/strong>, 78, 190\u2013194.<\/li>\n\n\n\n
  • Ashida, Y., et al<\/em>. Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure\u2013activity study on simplified analogs of the receptor-recognition domain. Bioorg. Med. Chem<\/em>. 2016<\/strong>, 24<\/em>, 4218\u20134227.<\/li>\n<\/ul>\n\n\n\n

    <\/p>\n\n<\/div>

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    Research Area:\u3000<\/strong>Biological Molecular Chemistry<\/mark>
    Research Specialization:\u3000<\/strong>Chemical Biology<\/mark>\u3000
    <\/strong>Name:\u3000<\/strong>YANAGITA, Ryo C.<\/mark><\/h2>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    Keywords\uff1aNatural product\uff0ctumor promoter\uff0canalog synthesis<\/strong><\/p>\n\n\n\n

    Recent Research<\/strong><\/p>\n<\/div>\n\n\n\n

    <\/div>\n\n\n\n
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    1.Development of simplified analogs of naturally-occurring tumor promoters<\/strong><\/h2>\n\n\n\n
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    \u3000Tumor promoters are compounds which enhance tumorigenesis in cells initiated by a carcinogen.  Recently, design and synthesis of simplified analogs of naturally-occurring tumor promoters with desirable therapeutic effects including anticancer effect have been reported.<\/p>\n\n\n\n

         We are currently studying on the development of simplified analogs of aplysiatoxin, a polyacetate isolated from sea hare, and thapsigargin, a sesquiterpene lactone isolated from Apiaceae plant, being synthetically accessible and having less side effect.<\/p>\n<\/div>\n\n\n\n

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    2.    Screening of new protein kinase C ligands with anti-proliferative activity<\/strong><\/h2>\n\n\n\n
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         Protein kinase C (PKC) is a family of serine\/threonine kinase that involves in many cellular function, and are attracted as potential therapeutic target for the treatment of cancer, Alzheimer\u2019s disease, and AIDS.<\/p>\n\n\n\n

         We are searching for new PKC ligands from plant sources by an assay using synthetic PKC C1 peptides.<\/p>\n<\/div>\n\n\n\n

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    3.Development of biologically active derivatives of naturally-rare monosaccharide<\/strong><\/h2>\n\n\n\n

         Several of naturally-occurring monosaccharides are found to exhibit biological activities including anti-cancer activity. We currently focus our attention on the development of rare monosaccharide derivatives with \u201cunnatural\u201d moiety to improve their cell permeability and biological activities.<\/p>\n\n\n\n

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    Publications<\/strong><\/p>\n<\/div>

    \"\"<\/figure><\/div>\n\n\n\n

    Ueno, S., et al. <\/em>Identification and Biological Activities of Bryostatins from Japanese Bryozoan. Biosci<\/em>. <\/em>Biotechnol<\/em>. <\/em>Biochem<\/em>. <\/em>2012<\/strong>, 76<\/em>, 1041\u20131043.<\/p>\n\n\n\n

    Yanagita, R. C., et al. <\/em>Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities. <\/em>Bioorg<\/em>. Med. Chem. Lett<\/em>. 2013<\/strong>, 23<\/em>, 4319\u20134323.
    Yanagita, R. C., et al. <\/em>Anti-proliferative activity of 6-O<\/em>-acyl-D-allose against the human leukemia MOLT-4F cell line. Biosci<\/em>. <\/em>Biotechnol<\/em>. <\/em>Biochem<\/em>. <\/em>2014<\/strong>, 78, 190\u2013194.<\/p>\n\n\n\n

    Ashida, Y., et al<\/em>. Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure\u2013activity study on simplified analogs of the receptor-recognition domain. Bioorg<\/em>. Med. Chem<\/em>. 2016<\/strong>, 24<\/em>, 4218\u20134227.<\/p>\n\n<\/div><\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":15794,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","ub_ctt_via":"","footnotes":""},"class_list":["post-2182","research","type-research","status-publish","has-post-thumbnail","hentry","research_keyword-141","research_keyword-157","research_keyword-156","research_category-124","center_category-258","center_category-260","sdgs_category-6","sdgs_category-12"],"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/2182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2182"}],"version-history":[{"count":90,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/2182\/revisions"}],"predecessor-version":[{"id":62263,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/2182\/revisions\/62263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/15794"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}