{"id":2258,"date":"2012-01-18T11:40:55","date_gmt":"2012-01-18T02:40:55","guid":{"rendered":"http:\/\/www.ag.kagawa-u.ac.jp?post_type=research&p=2258"},"modified":"2024-05-09T11:49:05","modified_gmt":"2024-05-09T02:49:05","slug":"%e7%a7%8b%e5%85%89%e3%80%80%e5%92%8c%e4%b9%9f%e3%80%80%ef%bc%88%e6%a4%8d%e7%89%a9%e7%97%85%e7%90%86%e5%ad%a6%ef%bc%89","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e7%a7%8b%e5%85%89%e3%80%80%e5%92%8c%e4%b9%9f%e3%80%80%ef%bc%88%e6%a4%8d%e7%89%a9%e7%97%85%e7%90%86%e5%ad%a6%ef%bc%89","title":{"rendered":"\u79cb\u5149\u3000\u548c\u4e5f"},"content":{"rendered":"\n
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English<\/div><\/div><\/div><\/div>\n
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\u9818\u3000\u57df\u3000\u540d\u3000\u3000\u690d\u7269\u79d1\u5b66\u3000<\/mark>\u3000\u3000\u3000<\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000  \u79cb\u3000\u5149\u3000\u548c\u3000\u4e5f<\/mark>\u3000<\/strong><\/h2>\n<\/div>\n\n\n\n
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\u7814\u7a76\u5206\u91ce\u3000\u690d\u7269\u75c5\u7406\u5b66<\/mark>\u3000<\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
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\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a  \u5bbf\u4e3b\u7279\u7570\u7684\u6bd2\u7d20, \u5e0c\u5c11\u7cd6,\u30b2\u30ce\u30e0, \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2, \u30ab\u30f3\u30ad\u30c4<\/strong><\/p>\n<\/div>\n\n\n\n

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\uff11\uff0eAlternaria<\/em>\u5c5e\u83cc\u306e\u751f\u7523\u3059\u308b\u5bbf\u4e3b\u7279\u7570\u7684\u6bd2\u7d20\u751f\u5408\u6210\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n

Alternaria<\/em>\u5c5e\u83cc\u306e\u3044\u304f\u3064\u304b\u306e\u7cfb\u7d71\u304c\u751f\u7523\u3059\u308b\u4f4e\u5206\u5b50\u306e2\u6b21\u5316\u5408\u7269\u306b\u3001\u5bbf\u4e3b\u7279\u7570\u7684\u6bd2\u7d20\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u304c\u3042\u308b\uff0e\u5bbf\u4e3b\u5f97\u7684\u6bd2\u7d20\u304c\u6bd2\u6027\u3092\u793a\u3059\u690d\u7269\u3068\uff0c\u305d\u306e\u6bd2\u7d20\u306e\u751f\u7523\u83cc\u304c\u611f\u67d3\u3067\u304d\u308b\u5bbf\u4e3b\u7bc4 \u56f2\u306f\u4e00\u81f4\u3057\uff0c\u6bd2\u7d20\u751f\u7523\u80fd\u306e\u6d88\u5931\u306f\u75c5\u539f\u6027\u306e\u5931\u6d3b\u306b\u76f4\u7d50\u3059\u308b\uff0e\u672c\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u30c7\u30ab\u30c8\u30ea\u30a8\u30f3\u9178\u30a8 \u30b9\u30c6\u30eb\u5316\u5408\u7269\uff08ACT\u6bd2\u7d20\uff09\u3068\u30dd\u30ea\u30b1\u30c1\u30c9\u5316\u5408\u7269\uff08ACR\u6bd2\u7d20\uff09\u306e\u5bbf\u4e3b\u7279\u7570\u7684\u6bd2\u7d20\u306b\u7740\u76ee\u3057\u3001\u3053\u308c\u3089\u306e \u751f\u5408\u6210\u9175\u7d20\u3084\u5236\u5fa1\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u306f\uff0c\u7279\u5b9a\u306e\u5c0f\u578b\u67d3\u8272\u4f53\u4e0a\u306b\u30af\u30e9\u30b9\u30bf\u30fc\u5316\u3057\u3066\u5ea7 \u4e57\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3057\u305f\uff0e\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u7fa4\u306e\u6a5f\u80fd\u3092\uff0c\u76f8\u540c\u7d44\u307f\u63db\u3048\u3092\u4ecb\u3057\u305f\u6a19\u7684\u907a\u4f1d\u5b50\u7834 \u58ca\u6cd5\u3084RNA\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u6cd5\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\uff0c\u6a19\u7684\u3068\u3059\u308b\u907a\u4f1d\u5b50\u7523\u7269\u306e\u6a5f\u80fd\u6d88\u5931\u304c\u6bd2\u7d20\u751f\u7523 \u306e\u505c\u6b62\u306b\u76f4\u7d50\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u6bd2\u7d20\u751f\u5408\u6210\u306b\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u3066\u304d\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

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\uff12\uff0etRNA-Ala\u306e\u4ecb\u5728\u9818\u57df\u4fee\u98fe\u4e0d\u5168\u306b\u3088\u308b\u690d\u7269\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u767a\u751f\u6a5f\u69cb<\/strong><\/h2>\n\n\n\n

   \u5bbf\u4e3b\u7279\u7570\u7684ACR\u6bd2\u7d20\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u30b3\u30fc\u30c9\u3059\u308bACRS\u907a\u4f1d\u5b50\u306f\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u306etRNA-Ala\u306e\u4ecb\u5728\u9818\u57df\u306b\u5ea7\u4e57\u3057, \u975e\u611f\u53d7\u6027\u54c1\u7a2e\u3067\u306f\u30d7\u30ed\u30bb\u30c3\u30b7\u30f3\u30b0\u306b\u3088\u308a\u4fee\u98fe\u5206\u89e3\u3055\u308c\u308b\uff0e\u672c\u7814\u7a76\u5ba4\u3067\u306f, \u3053\u306e\u30d7\u30ed\u30bb\u30c3\u30b7\u30f3\u30b0\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8907\u5408\u4f53\u306e\u69cb\u6210\u30bf\u30f3\u30d1\u30af\u3092\u7db2\u7f85\u7684\u306b\u89e3\u6790\u3057\uff0c\uff11\uff0e\u306e\u7814\u7a76\u3068\u3068\u3082\u306b, \u690d\u7269\u5074\u30fb\u75c5\u539f\u83cc\u5074\u306e\u53cc\u65b9\u304b\u3089\u7279\u7570\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\uff0e<\/p>\n<\/div>\n\n\n\n

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\uff13\uff0e\u5e0c\u5c11\u7cd6\u306e\u690d\u7269\u3078\u306e\u4f5c\u7528\u3068\u305d\u306e\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/h2>\n\n\n\n

   \u672c\u7814\u7a76\u306f\uff0c\u8fb2\u696d\u751f\u7523\u5206\u91ce\u306b\u5e0c\u5c11\u7cd6\u3092\u5229\u7528\u3057\u305f\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u5275\u51fa\u3092\u76ee\u6307\u3057\uff0c\u9999\u5ddd\u5927\u5b66\u304c\u6709\u3059\u308b\u72ec\u5275\u7684\u306a\u5e0c\u5c11\u7cd6\u7814\u7a76\u30b7\u30fc\u30ba\u3092\u6d3b\u7528\u3057\u3066\uff0c\u95a2\u4fc2\u4f01\u696d\u3068\u9023\u643a\u3092\u56f3\u308a\u306a\u304c\u3089\uff0c\u690d\u7269\u306e\u751f\u4f53\u9632\u5fa1\u3084\u751f\u9577\u8abf\u7bc0\u3082\u3057\u304f\u306f\u75c5\u539f\u83cc\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u304a\u3044\u3066\uff0c\u5e0c\u5c11\u7cd6\u306e\u679c\u305f\u3059\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u8a66\u307f\u3066\u3044\u308b\uff0e\u3055\u3089\u306b\uff0c\u5e0c\u5c11\u7cd6\u3092\u751f\u7523\u3059\u308b\u690d\u7269\u3067\u3042\u308b\u30ba\u30a4\u30ca\u306e\u7d44\u7e54\u57f9\u990a\u6cd5\u3092\u78ba\u7acb\u3057\uff0c\u30ba\u30a4\u30ca\u306e\u7279\u6027\u3092\u62c5\u3046\u751f\u7406\u30fb\u751f\u5316\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\u7684\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

HP<\/mark>\u3000http:\/\/www.ag.kagawa-u.ac.jp\/plantpathology\/index.html<\/a><\/strong><\/p>\n<\/div>\n\n\n\n

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\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>

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Endopolygalacturonase is essential for citrus black rot caused by Alternaria citri <\/em>but not brown spot caused by Alternaria alternata<\/em>(2001) A Isshiki, K Akimitsu, M Yamamoto, H Yamamoto, Molecular Plant-Microbe Interactions 14 : 749-757.<\/mark><\/p>\n\n\n\n

Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata <\/em>(2012) T Tsuge, Y Harimoto, K Akimitsu, K Ohtani, M Kodama, Y Akagi, M Egusa, \u2026, FEMS Microbiology Reviews 37: 44-66.<\/mark><\/p>\n\n\n\n

Molecular, ecological and evolutionary approaches to understanding Alternaria diseases of citrus (2003) K Akimitsu, TL Peever, LW Timmer, Molecular Plant Pathology 4: 435-446.<\/mark><\/p>\n\n\n\n

Sensitivity to Alternaria alternata <\/em>toxin in citrus because of altered mitochondrial RNA processing (2002) K Ohtani, H Yamamoto, K Akimitsu, Proceedings of the National Academy of Sciences 99: 2439-2444.<\/mark><\/p>\n\n\n\n

The rare sugar D-allose acts as a triggering molecule of rice defence via ROS generation (2013) A Kano, T Fukumoto, K Ohtani, A Yoshihara, T Ohara, S Tajima, K Izumori, . K Akimitsu, Journal of Experimental Botany 64: 4939-4951.<\/mark><\/p>\n\n<\/div>

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Research Area:\u3000<\/strong>Plant Science<\/mark><\/h2>\n\n\n\n

Research Specialization:\u3000<\/strong>Plant Pathology<\/mark>\u3000<\/strong><\/h2>\n\n\n\n

Name:\u3000<\/strong>AKIMITSU, Kazuya<\/mark><\/h2>\n\n\n\n
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Keywords\uff1a Host-selective toxin, Rare sugar, Genome, Mitochondria, Citrus<\/p>\n<\/div>\n\n\n\n

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Recent Research<\/strong><\/h2>\n\n\n\n

\uff11\uff0eBiosynthesis gene cluster of Host-selective Toxin from Alternaria <\/em>species<\/strong><\/h2>\n\n\n\n

     Host-selective toxins are second metabolic compounds with a low molecular weight, which are produced by several different pathotypes of Alternaria <\/em>species.  The host-range of toxin producer is equal to the host-selectivity of the toxin, and a loss of the toxin production leads a loss of pathogenicity. In our laboratory, we identified one dispensable chromosome carrying biosynthetic gene cluster for esters of 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (ACT-toxin) and another chromosome carrying that for polyketide (ACR-toxin). Target gene disruption and RNA silencing of the genes in the respective cluster caused a loss of the toxin production and pathogenicity, indicating the necessity of these genes in the toxin production as well as the pathogenicity.<\/p>\n\n\n\n

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\uff12\uff0eMechanism for appearance of plant mitochondrial disease cause by disfunction in modification of internal region of tRNA-Ala<\/strong><\/h2>\n\n\n\n

   ACRS<\/em> gene encoding ACR-toxin receptor protein is located in the internal region of tRNA-Ala in mitochondrial genome, and the transcript of the region is processed in the toxin-insensitive cultivars of citrus.  We examine the processing protein complex of the receptor gene transcript, and qualify the mechanism of host selectivity from both pathogen and host sides.<\/p>\n<\/div>\n\n\n\n

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\uff13\uff0eMechanism of rare sugar effects in plants<\/strong><\/h2>\n\n\n\n

   Rare sugars give effects on plants; such as a transient growth inhibition and induction of defense-related gene expression. The mechanism controlling these effects was identified and we are  trying to use them for agricultural practices. Itea<\/em> plant producing rare sugar is also examined on the processes of the sugar production as well as the evolutional role of rare sugar production.<\/p>\n<\/div>\n\n\n\n

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HP<\/mark>\u3000http:\/\/www.ag.kagawa-u.ac.jp\/plantpathology\/index.html<\/a><\/strong><\/p>\n\n\n\n

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References<\/strong><\/p>\n<\/div>

\"\"<\/figure><\/div>\n\n\n\n

Endopolygalacturonase is essential for citrus black rot caused by Alternaria citri <\/em>but not brown spot caused by Alternaria alternata<\/em>(2001) A Isshiki, K Akimitsu, M Yamamoto, H Yamamoto, Molecular Plant-Microbe Interactions 14 : 749-757.<\/mark><\/p>\n\n\n\n

Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata <\/em>(2012) T Tsuge, Y Harimoto, K Akimitsu, K Ohtani, M Kodama, Y Akagi, M Egusa, \u2026, FEMS Microbiology Reviews 37: 44-66.<\/mark><\/p>\n\n\n\n

Molecular, ecological and evolutionary approaches to understanding Alternaria diseases of citrus (2003) K Akimitsu, TL Peever, LW Timmer, Molecular Plant Pathology 4: 435-446.<\/mark><\/p>\n\n\n\n

Sensitivity to Alternaria alternata <\/em>toxin in citrus because of altered mitochondrial RNA processing (2002) K Ohtani, H Yamamoto, K Akimitsu, Proceedings of the National Academy of Sciences 99: 2439-2444.<\/mark><\/p>\n\n\n\n

The rare sugar D-allose acts as a triggering molecule of rice defence via ROS generation (2013) A Kano, T Fukumoto, K Ohtani, A Yoshihara, T Ohara, S Tajima, K Izumori, . K Akimitsu, Journal of Experimental Botany 64: 4939-4951.<\/mark><\/p>\n\n<\/div><\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":15793,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","ub_ctt_via":"","footnotes":""},"class_list":["post-2258","research","type-research","status-publish","has-post-thumbnail","hentry","research_category-158","center_category-257","center_category-258","sdgs_category-6","sdgs_category-9","sdgs_category-17","sdgs_category-12","sdgs_category-18","sdgs_category-5"],"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/2258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2258"}],"version-history":[{"count":25,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/2258\/revisions"}],"predecessor-version":[{"id":32750,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/2258\/revisions\/32750"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/15793"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}