{"id":25127,"date":"2020-10-06T17:13:06","date_gmt":"2020-10-06T08:13:06","guid":{"rendered":"?post_type=research&p=25127"},"modified":"2025-10-03T08:31:32","modified_gmt":"2025-10-02T23:31:32","slug":"%e8%8a%b1%e6%9c%a8%e7%a5%90%e8%bc%94","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e8%8a%b1%e6%9c%a8%e7%a5%90%e8%bc%94","title":{"rendered":"\u82b1\u6728 \u7950\u8f14"},"content":{"rendered":"
\n
\n
\n
\u65e5\u672c\u8a9e<\/div><\/div>
\n
English<\/div><\/div><\/div><\/div>\n
\n\n
\n
\n
\n
\n

\u9818\u3000\u57df\u3000\u540d\u3000\u751f\u7269\u5206\u5b50\u5316\u5b66<\/mark><\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000\u82b1\u3000\u6728\u3000\u3000\u7950\u3000\u8f14<\/mark><\/strong><\/h2>\n<\/div>\n\n\n\n
\n

\u7814\u7a76\u5206\u91ce\u3000\u751f\u7269\u5236\u5fa1\u5206\u5b50\u5316\u5b66<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u751f\u7269\u6d3b\u6027\u5206\u5b50\uff0c\u8ee2\u79fb\u963b\u5bb3\uff0c\u5897\u6b96\u963b\u5bb3\uff0c\u6709\u6a5f\u5408\u6210<\/strong><\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c<\/strong><\/h2>\n\n\n\n
\n
\n

1. \u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u306e\u69cb\u7bc9<\/strong><\/h2>\n\n\n\n

\u3000\u65b0\u3057\u3044\u85ac\u5264\u3092\u63a2\u7d22\u3059\u308b\u5834\u5408\u306b\u306f\uff0c\u63a2\u7d22\u8cc7\u6e90\u3068\u3057\u3066\u591a\u69d8\u306a\u5316\u5408\u7269\u3092\u5165\u624b\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u304c\u6210\u5426\u306e\u9375\u3092\u63e1\u308b\uff0e\u305d\u3053\u3067\uff0c\u690d\u7269\u3084\u98df\u54c1\u7d20\u6750\u306a\u3069\u306e\u542b\u6709\u6210\u5206\u3092\u62bd\u51fa\u3057\uff0c\u751f\u7269\u6d3b\u6027\u5206\u5b50\u306e\u7cbe\u88fd\u306a\u3089\u3073\u306b\u69cb\u9020\u89e3\u6790\u3092\u884c\u3046\uff0e\u307e\u305f\uff0c\u5929\u7136\u306b\u306f\u5b58\u5728\u3057\u306a\u3044\u30e6\u30cb\u30fc\u30af\u306a\u69cb\u9020\u3092\u3082\u3063\u305f\u5316\u5408\u7269\u3092\u6709\u6a5f\u5408\u6210\u306b\u3088\u3063\u3066\u4f9b\u7d66\u3059\u308b\uff0e\u5929\u7136\u7269\u3068\u5408\u6210\u5316\u5408\u7269\u306e\u4e21\u65b9\u3092\u542b\u3093\u3060\u72ec\u81ea\u306e\u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u69cb\u7bc9\u3057\uff0c\u751f\u7269\u6d3b\u6027\u8a55\u4fa1\u3092\u884c\u3046\uff0e<\/p>\n\n\n\n

2. \u8ee2\u79fb\u30fb\u5897\u6b96\u963b\u5bb3\u5264\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/strong><\/h2>\n\n\n\n

\u3000\u5b50\u5bae\u4f53\u90e8\u306e\u5185\u58c1\u3092\u69cb\u6210\u3057\u3066\u3044\u308b\u5185\u819c\u7d30\u80de\u306f\u5468\u8fba\u306e\u7d44\u7e54\u306b\u8ee2\u79fb\u3057\u3084\u3059\u304f\uff0c\u5b50\u5bae\u5185\u819c\u75c7\u30fb\u817a\u7b4b\u75c7\u3068\u3044\u3063\u305f\u75be\u60a3\u304c\u597d\u767a\u3059\u308b\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\uff0e\u5f93\u3063\u3066\uff0c\u672c\u7d30\u80de\u306e\u8ee2\u79fb\u3084\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b\u5316\u5408\u7269\u306f\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6709\u671b\u3067\u3042\u308b\uff0e\u305d\u3053\u3067\uff0c\u5b50\u5bae\u7531\u6765\u306e\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066\u7c21\u4fbf\u306b\u8ee2\u79fb\u304a\u3088\u3073\u5897\u6b96\u963b\u5bb3\u6d3b\u6027\u3092\u8a55\u4fa1\u3059\u308b\u65b9\u6cd5\u3092\u78ba\u7acb\u3057\uff0c\u300c\u8ab2\u984c1\u300d\u3067\u96c6\u3081\u305f\u5316\u5408\u7269\u306e\u4e2d\u304b\u3089\u533b\u85ac\u54c1\u5019\u88dc\u3092\u63a2\u7d22\u3059\u308b\uff0e<\/p>\n\n\n\n

3. \u751f\u7269\u6d3b\u6027\u5206\u5b50\u306e\u4f5c\u7528\u6a5f\u69cb\u89e3\u6790<\/strong><\/h2>\n\n\n\n

\u3000\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u3063\u3066\u898b\u3044\u3060\u3055\u308c\u305f\u5316\u5408\u7269\u304c\uff0c\u751f\u4f53\u5185\u3067\u3069\u306e\u3088\u3046\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u306e\u304b\uff0c\u751f\u5316\u5b66\u30fb\u7d30\u80de\u751f\u7269\u5b66\u7684\u306a\u624b\u6cd5\u3092\u7528\u3044\u3066\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3059\u308b\uff0e<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
\n

\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>

\"\"<\/figure><\/div>\n\n\n\n

\u2022Hanaki, Y. et al<\/em>., Structure\u2013activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity. Tetrahedron<\/em>, 69<\/strong> <\/em>(36), 7636-7645 (2013). <\/p>\n\n\n\n

\u2022 Hanaki, Y. et al<\/em>., Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules<\/em>, 22<\/strong> <\/em>(4), 631 (2017). <\/p>\n\n\n\n

\u2022 Hanaki, Y. et al<\/em>., Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem. Biophys. Res. Commun.<\/em>, 495<\/strong> (1), 438-445 (2018).<\/p>\n\n<\/div>

\n\n
\n
\n

Research Area:\u3000<\/strong>Biological Molecular Chemistry<\/mark>\u3000
<\/strong>Research Specialization:\u3000<\/strong>Organic and Bioregulation Chemistry<\/mark>
<\/strong>Name:\u3000<\/strong>HANAKI, Yusuke<\/mark><\/h2>\n\n\n\n
\"\"<\/figure>\n\n\n\n

Keywords\uff1aBioactive molecule\uff0cMigration inhibitor, Organic synthesis<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

Recent Research<\/strong><\/h2>\n\n\n\n
\n
\n

1.\u3000Establishment of a novel chemical library<\/strong><\/h2>\n\n\n\n

     Chemical libraries contribute to drug discoveries. We are collecting bioactive molecules from natural sources and synthesizing unnatural compounds to create a novel small molecule library.<\/p>\n\n\n\n

2.\u3000Screening for migration\/proliferation inhibitors<\/strong><\/h2>\n\n\n\n

     Migration of endometrial cells is a cause behind common diseases such as adenomyosis and endometriosis.  We are working on developing a rapid screening method for migration\/proliferation inhibitors as novel medicinal seeds.<\/p>\n\n\n\n

3.\u3000Mechanisms of action of bioactive compounds<\/strong><\/h2>\n\n\n\n

     We are trying to elucidate the mode of action of isolated bioactive molecules by biochemical and cell biological approaches.<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n
\n

Publications<\/strong><\/p>\n<\/div>

\"\"<\/figure><\/div>\n\n\n\n
    \n
  • Hanaki, Y. et al<\/em>., Structure\u2013activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity. Tetrahedron<\/em>, 69<\/strong>(36), 7636-7645 (2013).<\/li>\n\n\n\n
  • Hanaki, Y. et al<\/em>., Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules<\/em>, 22<\/strong>(4), 631 (2017).<\/li>\n\n\n\n
  • Hanaki, Y. et al<\/em>., Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem. Biophys. Res. Commun.<\/em>, 495<\/strong> (1), 438-445 (2018).<\/li>\n<\/ul>\n\n<\/div><\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":25385,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","ub_ctt_via":"","footnotes":""},"class_list":["post-25127","research","type-research","status-publish","has-post-thumbnail","hentry","research_keyword-339","research_keyword-340","research_keyword-337","research_keyword-338","research_category-124","center_category-258","center_category-260","sdgs_category-6","sdgs_category-12"],"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/25127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25127"}],"version-history":[{"count":9,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/25127\/revisions"}],"predecessor-version":[{"id":61529,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/25127\/revisions\/61529"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/25385"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}