{"id":26511,"date":"2021-07-26T10:40:22","date_gmt":"2021-07-26T01:40:22","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/?post_type=research&p=26511"},"modified":"2025-10-03T08:32:00","modified_gmt":"2025-10-02T23:32:00","slug":"%e6%9d%be%e6%b2%a2-%e6%99%ba%e5%bd%a6","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e6%9d%be%e6%b2%a2-%e6%99%ba%e5%bd%a6","title":{"rendered":"\u677e\u6ca2 \u667a\u5f66"},"content":{"rendered":"
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\u9818\u3000\u57df\u3000\u540d\u3000\u3000\u751f\u547d\u6a5f\u80fd\u79d1\u5b66<\/mark><\/strong><\/h2>\n\n\n\n

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\u7814\u7a76\u5206\u91ce\u3000\u9175\u7d20\u5b66<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
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\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c<\/strong><\/h2>\n\n\n\n

\uff11. \u690d\u7269\u306e\u7d30\u80de\u58c1\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u306e\u63a2\u7d22<\/strong><\/h2>\n\n\n\n

\u3000\u690d\u7269\u306e\u7d30\u80de\u58c1\u306b\u306f\u69d8\u3005\u306a\u591a\u7cd6\u985e\u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u4e2d\u306b\u306f\u975e\u5e38\u306b\u8907\u96d1\u306a\u69cb\u9020\u3092\u3057\u305f\u591a\u7cd6\u985e\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u5fae\u751f\u7269\u306f\u3053\u306e\u7d30\u80de\u58c1\u3092\u5229\u7528\u3059\u308b\uff08\u98df\u3079\u308b\uff09\u305f\u3081\u306b\u591a\u7a2e\u591a\u69d8\u306a\u5206\u89e3\u9175\u7d20\u3092\u751f\u7523\u3057\u3066\u3044\u307e\u3059\u3002\u751f\u7523\u3055\u308c\u308b\u9175\u7d20\u306f\u305d\u308c\u305e\u308c\u7570\u306a\u3063\u305f\u6a5f\u80fd\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u9175\u7d20\u304c\u5354\u8abf\u7684\u306b\u50cd\u304f\u3053\u3068\u306b\u3088\u3063\u3066\u5206\u89e3\u306f\u6210\u3057\u9042\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000\u3053\u308c\u3089\u4e00\u3064\u4e00\u3064\u306e\u9175\u7d20\u3001\u307e\u305f\u305d\u306e\u9175\u7d20\u3092\u751f\u7523\u3059\u308b\u5fae\u751f\u7269\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u300c\u8907\u96d1\u306a\u591a\u7cd6\u985e\u3092\u7dfb\u5bc6\u306b\u5206\u89e3\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\uff08\uff1d\u5fae\u751f\u7269\u306e\u6226\u7565<\/strong>\uff09\u300d\u3092\u89e3\u660e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\"\u30ad\u30b7\u30ed\u30b0\u30eb\u30ab\u30f3\uff08\u7d30\u80de\u58c1\u591a\u7cd6\u985e\uff09\u3092\u5206\u89e3\u3059\u308b\u9eb9\u83cc\u306e\u9175\u7d20\"<\/figure>\n\n\n\n

\uff12. \u9175\u7d20\u306e\u9032\u5316<\/strong><\/h2>\n\n\n\n

\u3000<\/strong>\u751f\u7269\u3082\u305d\u306e\u751f\u7269\u304c\u6301\u3064\u9175\u7d20\u3082\u9577\u3044\u5e74\u6708\u3092\u304b\u3051\u3066\u5c11\u3057\u305a\u3064\u5909\u5316\u3057\u3001\u65b0\u3057\u3044\u6027\u8cea\uff08\u7279\u5fb4\uff09\u3092\u6301\u3064\u3082\u306e\u304c\u51fa\u73fe\u3057\u307e\u3059\u3002\u5b9f\u9a13\u5ba4\u306b\u304a\u3044\u3066\u3082\u3001\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5b89\u5b9a\u6027\u304c\u5411\u4e0a\u3057\u305f\u308a\uff08\u4f4e\u4e0b\u3057\u305f\u308a\uff09\u3001\u89e6\u5a92\u3059\u308b\u53cd\u5fdc\u304c\u5909\u5316\u3057\u305f\u308a\u3057\u307e\u3059\u3002\u3053\u306e\u9175\u7d20\u306e\u9032\u5316\u3092\u5229\u7528\u3057\u3001\u9175\u7d20\u306e\u6027\u80fd\u306e\u5411\u4e0a\u3084\u3001\u9175\u7d20\u306e\u53cd\u5fdc\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

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\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>

\"\"<\/figure><\/div>\n\n\n\n
    \n
  • Matsuzawa, T., et al. <\/em>(2021) Enzymatic degradation of xyloglucans by Aspergillus <\/em>species: a comparative view of this\u00a0 genus. Appl. Microbiol. Biotechnol.<\/em><\/strong> 105:2701\u20132711<\/li>\n\n\n\n
  • Matsuzawa, T., et al<\/em>. (2020) Identification and characterization of two xyloglucan-specific endo-1,4-glucanases in Aspergillus oryzae<\/em>. Appl. Microbiol. Biotechnol.<\/em><\/strong> 104:8761\u20138773<\/li>\n\n\n\n
  • Matsuzawa, T., et al. <\/em>(2020) Identification and characterization of \u03b1-xylosidase involved in xyloglucan degradation in Aspergillus oryzae<\/em>. Appl. Microbiol. Biotechnol.<\/em><\/strong> 104:201\u2013210<\/li>\n\n\n\n
  • Matsuzawa, T., et al. <\/em>(2019) Cooperation between \u03b2-galactosidase and an isoprimeverose-producing oligoxyloglucan hydrolase is key for xyloglucan degradation in Aspergillus oryzae<\/em>. FEBS J. <\/em><\/strong>286:3182\u20133193<\/li>\n\n\n\n
  • Matsuzawa, T., et al. <\/em>(2019) Crystal structure and substrate recognition mechanism of Aspergillus oryzae<\/em> isoprimeverose-producing enzyme. J. Struct. Biol.<\/em><\/strong> 205:84\u201390<\/li>\n\n\n\n
  • Matsuzawa, T., et al. <\/em>(2016) Identification of the gene encoding isoprimeverose-producing oligoxyloglucan hydrolase in Aspergillus oryzae<\/em>. J. Biol. Chem.<\/em><\/strong> 291:5080\u20135087<\/li>\n\n\n\n
  • Matsuzawa, T., et al. <\/em>(2016) Crystal structure and identification of a key amino acid for glucose tolerance, substrate specificity, and transglycosylation activity of metagenomic \u03b2-glucosidase Td2F2. FEBS J.<\/em><\/strong> 283:2340\u20132353<\/li>\n<\/ul>\n\n<\/div>
    \n\n
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    Research Area:\u3000Applied Life Science<\/mark><\/strong><\/h2>\n\n\n\n

    Research Specialization:\u3000Enzymology<\/mark><\/strong><\/h2>\n\n\n\n

    Name:\u3000MATSUZAWA, Tomohiko<\/mark><\/strong><\/h2>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    Key ward\uff1a Enzyme, Sugar, Fungi, Yeast, Metagenome<\/p>\n<\/div>\n\n\n\n

    \n
    \"MATSUZAWA,<\/figure>\n<\/div>\n<\/div>\n\n\n\n

    Recent Research<\/strong><\/h2>\n\n\n\n

    \uff11. Plant Polysaccharides Degradation-Related Enzymes<\/strong><\/h2>\n\n\n\n

    \u3000Plants produce many kinds of polysaccharides and microorganisms produce plant polysaccharides degradation-related enzymes to assimilate plant polysaccharides. Each enzyme has distinct functions in the degradation, and cooperative actions of these enzymes are crucial to degrade plant polysaccharides.<\/p>\n\n\n\n

    \u00a0 Our study focus on the identification and characterization of novel plant polysaccharides degradation-related enzymes from microorganisms, including fungi and metagenome.<\/p>\n\n\n\n

    \"Xyloglucan<\/figure>\n\n\n\n

    \uff12. Evolution of Enzymes<\/strong><\/h2>\n\n\n\n

    \u3000Random and site-direct mutagenesis can change enzymatic properties, such as thermal stability and substrate specificity.\u00a0 We use the mutagenesis techniques to improve the enzymatic activities and to elucidate the molecular mechanism of enzymatic reactions.<\/p>\n\n\n\n

    \n

    Publications<\/strong><\/p>\n<\/div>

    \"\"<\/figure><\/div>\n\n\n\n
      \n
    • Matsuzawa, T., et al. <\/em>(2021) Enzymatic degradation of xyloglucans by Aspergillus <\/em>species: a comparative view of this\u00a0 genus. Appl. Microbiol. Biotechnol.<\/em><\/strong> 105:2701\u20132711<\/li>\n\n\n\n
    • Matsuzawa, T., et al<\/em>. (2020) Identification and characterization of two xyloglucan-specific endo-1,4-glucanases in Aspergillus oryzae<\/em>. Appl. Microbiol. Biotechnol.<\/em><\/strong> 104:8761\u20138773<\/li>\n\n\n\n
    • Matsuzawa, T., et al. <\/em>(2020) Identification and characterization of \u03b1-xylosidase involved in xyloglucan degradation in Aspergillus oryzae<\/em>. Appl. Microbiol. Biotechnol.<\/em><\/strong> 104:201\u2013210<\/li>\n\n\n\n
    • Matsuzawa, T., et al. <\/em>(2019) Cooperation between \u03b2-galactosidase and an isoprimeverose-producing oligoxyloglucan hydrolase is key for xyloglucan degradation in Aspergillus oryzae<\/em>. FEBS J. <\/em><\/strong>286:3182\u20133193<\/li>\n\n\n\n
    • Matsuzawa, T., et al. <\/em>(2019) Crystal structure and substrate recognition mechanism of Aspergillus oryzae<\/em> isoprimeverose-producing enzyme. J. Struct. Biol.<\/em><\/strong> 205:84\u201390<\/li>\n\n\n\n
    • Matsuzawa, T., et al. <\/em>(2016) Identification of the gene encoding isoprimeverose-producing oligoxyloglucan hydrolase in Aspergillus oryzae<\/em>. J. Biol. Chem.<\/em><\/strong> 291:5080\u20135087<\/li>\n\n\n\n
    • Matsuzawa, T., et al. <\/em>(2016) Crystal structure and identification of a key amino acid for glucose tolerance, substrate specificity, and transglycosylation activity of metagenomic \u03b2-glucosidase Td2F2. FEBS J.<\/em><\/strong> 283:2340\u20132353<\/li>\n<\/ul>\n\n<\/div><\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":26631,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-26511","research","type-research","status-publish","has-post-thumbnail","hentry","research_keyword-210","research_keyword-163","research_category-184","center_category-257","center_category-260","sdgs_category-348","sdgs_category-12"],"uagb_featured_image_src":{"full":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01.png",818,235,false],"thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01-150x150.png",150,150,true],"medium":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01-300x86.png",300,86,true],"medium_large":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01-768x221.png",640,184,true],"large":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01.png",640,184,false],"1536x1536":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01.png",818,235,false],"2048x2048":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01.png",818,235,false],"gb-block-post-grid-landscape":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01.png",600,172,false],"gb-block-post-grid-square":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01.png",600,172,false],"post-thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2021\/07\/img01-818x198.png",818,198,true]},"uagb_author_info":{"display_name":"\u7ba1\u7406\u8005","author_link":"https:\/\/www.ag.kagawa-u.ac.jp\/?author=1"},"uagb_comment_info":0,"uagb_excerpt":null,"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/26511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26511"}],"version-history":[{"count":7,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/26511\/revisions"}],"predecessor-version":[{"id":61530,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/26511\/revisions\/61530"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/26631"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}