{"id":30793,"date":"2023-04-03T14:20:47","date_gmt":"2023-04-03T05:20:47","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/?post_type=research&p=30793"},"modified":"2024-07-19T13:58:01","modified_gmt":"2024-07-19T04:58:01","slug":"%e5%8e%9f%e3%80%80%e5%ba%b7%e9%9b%85","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e5%8e%9f%e3%80%80%e5%ba%b7%e9%9b%85","title":{"rendered":"\u539f\u3000\u5eb7\u96c5"},"content":{"rendered":"
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\u9818\u3000\u57df\u3000\u540d\u3000\u751f\u7269\u5206\u5b50\u5316\u5b66<\/mark>\u3000\u3000\u3000<\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000 \u539f   \u5eb7 \u96c5<\/mark><\/strong>\u3000<\/strong><\/h2>\n<\/div>\n\n\n\n
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\u7814\u7a76\u5206\u91ce\u3000\u6d3b\u6027\u69cb\u9020\u5316\u5b66<\/mark>\u3000<\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
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\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u5929\u7136\u7269\uff0c\u690d\u7269\uff0c\u5fae\u751f\u7269\uff0c\u5171\u57f9\u990a\uff0c\u751f\u7269\u6d3b\u6027<\/strong><\/p>\n<\/div>\n\n\n\n

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\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c<\/strong><\/p>\n\n\n\n

\uff11\uff0e\u5929\u7136\u8cc7\u6e90\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u306e\u69cb\u7bc9<\/strong><\/h2>\n\n\n\n
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\u3000\u81ea\u7136\u754c\u306b\u5b58\u5728\u3059\u308b\u5929\u7136\u8cc7\u6e90\u304b\u3089\uff0c\u3053\u308c\u307e\u3067\u306b\u591a\u69d8\u306a\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\uff08\u5929\u7136\u7269\uff09\u304c\u5358\u96e2\uff0c\u69cb\u9020\u6c7a\u5b9a\u3055\u308c\u3066\u304d\u305f\uff0e\u305d\u3053\u3067\uff0c\u79c1\u9054\u306f\uff0c\u690d\u7269\u3084\u5fae\u751f\u7269\u7b49\u306e\u5929\u7136\u8cc7\u6e90\u3092\u72ec\u81ea\u306b\u53ce\u96c6\u30fb\u4fdd\u5b58\u3057\uff0c\u5929\u7136\u8cc7\u6e90\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u3084\u305d\u306e\u62bd\u51fa\u7269\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u306e\u69cb\u7bc9\u3092\u9032\u3081\u3066\u3044\u308b\uff0e\u3053\u306e\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u3092\u7528\u3044\u3066\u5929\u7136\u7269\u63a2\u7d22\u3092\u5b9f\u65bd\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

2\uff0e\u5fae\u751f\u7269\u306e\u4f11\u7720\u907a\u4f1d\u5b50\u6d3b\u6027\u5316<\/strong><\/h2>\n\n\n\n

\u3000\u5fae\u751f\u7269\u306e\u3082\u3064\u5929\u7136\u7269\u7523\u751f\u306b\u95a2\u4e0e\u3059\u308b\u751f\u5408\u6210\u907a\u4f1d\u5b50\u306f\uff0c\u305d\u306e\u591a\u304f\u304c\u4f11\u7720\u72b6\u614b\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u308b\uff0e\u305d\u3053\u3067\uff0c\u3053\u306e\u4f11\u7720\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u306b\u7e4b\u304c\u308b\uff0c\u69d8\u3005\u306a\u5fae\u751f\u7269\u57f9\u990a\u6cd5\u3092\u5b9f\u65bd\u30fb\u958b\u767a\u3057\uff0c\u65b0\u898f\u5929\u7136\u7269\u306e\u53d6\u5f97\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\uff0e\u3053\u306e\u57f9\u990a\u306e\u5b9f\u65bd\u30fb\u958b\u767a\u306f\uff0c1. \u3067\u793a\u3057\u305f\u5929\u7136\u8cc7\u6e90\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u306e\u62e1\u5145\u306b\u3082\u7e4b\u304c\u308b\uff0e\u8fd1\u5e74\uff0c\u79c1\u9054\u306f\u52d5\u7269\u7d30\u80de\u5b58\u5728\u4e0b\u3067\u306e\u5fae\u751f\u7269\u306e\u57f9\u990a\u6cd5\u306b\u3088\u308b\u5929\u7136\u7269\u63a2\u7d22\u3092\u63d0\u5531\u3057\uff0c\u5fae\u751f\u7269\u306e\u307f\u306e\u57f9\u990a\u3067\u306f\u7523\u751f\u3055\u308c\u306a\u3044\u65b0\u898f\u5929\u7136\u7269\u3092\u898b\u51fa\u3057\u305f\uff0e<\/p>\n<\/div>\n\n\n\n

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\uff13\uff0e\u65b0\u898f\u5929\u7136\u7269\u3084\u751f\u7269\u6d3b\u6027\u5929\u7136\u7269\u306e\u63a2\u7d22<\/strong><\/h2>\n\n\n\n

\u30001. \u304a\u3088\u30732. \u3067\u69cb\u7bc9\u3057\u305f\u5929\u7136\u8cc7\u6e90\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u3092\uff0c\u304c\u3093\u3084\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff0c\u611f\u67d3\u75c7\u306a\u3069\u3092\u6a19\u7684\u3068\u3057\u305f\u591a\u69d8\u306a\u751f\u7269\u6d3b\u6027\u8a66\u9a13\u3084\uff0cTLC\u3084HPLC\u306a\u3069\u306b\u3088\u308b\u7db2\u7f85\u7684\u5206\u6790\u3092\u7528\u3044\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\uff0e\u305d\u306e\u5f8c\uff0c\u5bfe\u8c61\u3068\u3057\u305f\u5929\u7136\u8cc7\u6e90\u62bd\u51fa\u7269\u3092\u5206\u96e2\u30fb\u7cbe\u88fd\u3057\uff0c\u65b0\u898f\u5929\u7136\u7269\u3084\u751f\u7269\u6d3b\u6027\u5929\u7136\u7269\u306e\u5358\u96e2\u30fb\u69cb\u9020\u6c7a\u5b9a\u3092\u9032\u3081\u3066\u3044\u308b\uff0e\u5358\u96e2\u3057\u305f\u5929\u7136\u7269\u306b\u3064\u3044\u3066\u306f\uff0c\u305d\u306e\u6a5f\u80fd\u89e3\u660e\u3084\u751f\u5408\u6210\u907a\u4f1d\u5b50\u306e\u63a8\u5b9a\u7b49\u3092\u8a66\u307f\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

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\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n
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  • Hara, Y. et al. <\/em>Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis<\/em>IFM 10554T<\/sup> in the presence of animal cells. J. Nat. Med. <\/em>72<\/strong>, 280-289 (2018).<\/li>\n\n\n\n
  • Hara, Y. et al. <\/em>Coculture of a pathogenic actinomycete and animal cells to produce nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect. Org. Lett. <\/em>20<\/strong>, 5831-5834 (2018).<\/li>\n\n\n\n
  • Hara, Y. et al. <\/em>Acacienone, a terpenoid\u2011like natural product having an unprecedented C20 framework isolated from Acacia mangium<\/em> leaves. J. Nat. Med. <\/em>75<\/strong>, 99-104 (2021).<\/li>\n\n\n\n
  • Hara, Y. et al. Isolation of ikahonone, 4-methyl-2,4-dihydroxy-3-pentanone from Bacillus cereus <\/em>IFM12235. Heterocycles<\/em> 105<\/strong>, 523-531 (2022).<\/li>\n\n\n\n
  • Hara, Y. et al. <\/em>Two bioactive compounds, uniformides A and B, isolated from a culture of Nocardia uniformis<\/em> IFM0856T<\/sup> in the presence of animal cells. Org. Lett<\/em>. 24<\/strong>, 5867 and  4998-5002 (2022).<\/li>\n<\/ul>\n\n<\/div>
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    Research Area:\u3000Biological Molecular Chemistry<\/mark>\u3000<\/strong><\/h2>\n\n\n\n

    Research Specialization:\u3000Natural Products Chemistry<\/mark>\u3000<\/strong><\/h2>\n\n\n\n

    Name:\u3000HARA, Yasumasa<\/mark><\/strong><\/h2>\n\n\n\n
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    Key words\uff1anatural products\uff0cplant, microorganism, biological activity<\/p>\n<\/div>\n\n\n\n

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    Recent Research<\/strong><\/h2>\n\n\n\n

    \uff11\uff0eEstablishment of natural resource collection<\/strong><\/h2>\n\n\n\n
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    We collect natural resources such as plants and microorganisms, and establish natural resource collections and the extract collections. We search for new natural products from these collection.<\/p>\n\n\n\n

    2\uff0eActivation of microbial biosynthetic genes<\/strong><\/h2>\n\n\n\n

     Many of the biosynthetic genes involved in the production of natural products in microorganisms are cryptic or silent. Therefore, we conduct and develop various microbial culture methods that lead to the activation of these genes in order to obtain new natural products.<\/p>\n\n\n\n

     Recently, we suggested a new method to search for natural products by culturing microorganisms in the presence of animal cells.<\/p>\n<\/div>\n\n\n\n

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    \uff13\uff0eSearch for new natural products and bioactive natural products<\/strong><\/h2>\n\n\n\n

    \u3000The collected natural resources are screened by various biological activity tests and  analysis by TLC and HPLC. We isolate new natural products and biologically active natural products\u3000from selected natural resources. Also, we try to elucidate the functions and estimate the biosynthetic genes of the isolated compounds.<\/p>\n\n\n\n

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    Publications<\/strong><\/p>\n<\/div>

    \"\"<\/figure><\/div>\n\n\n\n
      \n
    • Hara, Y. et al. <\/em>Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis<\/em>IFM 10554T<\/sup> in the presence of animal cells. J. Nat. Med. <\/em>72<\/strong>, 280-289 (2018).<\/li>\n\n\n\n
    • Hara, Y. et al. <\/em>Coculture of a pathogenic actinomycete and animal cells to produce nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect. Org. Lett. <\/em>20<\/strong>, 5831-5834 (2018).<\/li>\n\n\n\n
    • Hara, Y. et al. <\/em>Acacienone, a terpenoid\u2011like natural product having an unprecedented C20 framework isolated from Acacia mangium<\/em> leaves. J. Nat. Med. <\/em>75<\/strong>, 99-104 (2021).<\/li>\n\n\n\n
    • Hara, Y. et al. Isolation of ikahonone, 4-methyl-2,4-dihydroxy-3-pentanone from Bacillus cereus <\/em>IFM12235. Heterocycles<\/em> 105<\/strong>, 523-531 (2022).<\/li>\n\n\n\n
    • Hara, Y. et al. <\/em>Two bioactive compounds, uniformides A and B, isolated from a culture of Nocardia uniformis<\/em> IFM0856T<\/sup> in the presence of animal cells. Org. Lett<\/em>. 24<\/strong>, 5867 and  4998-5002 (2022).\n
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      • <\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n<\/div><\/div>\n <\/div>\n\n\n