{"id":3093,"date":"2012-01-23T11:24:45","date_gmt":"2012-01-23T02:24:45","guid":{"rendered":"http:\/\/www.ag.kagawa-u.ac.jp?post_type=research&p=3093"},"modified":"2024-05-09T11:42:25","modified_gmt":"2024-05-09T02:42:25","slug":"%e6%9c%a8%e6%9d%91%e7%be%a9%e9%9b%84%e3%80%80%ef%bc%88%e5%be%ae%e7%94%9f%e7%89%a9%e7%94%9f%e7%90%86%e5%ad%a6","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e6%9c%a8%e6%9d%91%e7%be%a9%e9%9b%84%e3%80%80%ef%bc%88%e5%be%ae%e7%94%9f%e7%89%a9%e7%94%9f%e7%90%86%e5%ad%a6","title":{"rendered":"\u6728\u6751\u3000\u7fa9\u96c4"},"content":{"rendered":"
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\u9818\u3000\u57df\u3000\u540d\u3000\u5fdc\u7528\u751f\u547d\u79d1\u5b66<\/mark><\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000 \u6728\u6751\u7fa9\u96c4<\/mark>\u3000<\/strong><\/h2>\n<\/div>\n\n\n\n
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\u7814\u7a76\u5206\u91ce\u3000\u5fae\u751f\u7269\u751f\u7406\u5b66<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
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\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u7c98\u6db2\u7d30\u83cc, \u30b7\u30b0\u30ca\u30eb\u7269\u8cea, ATP\u5408\u6210,\u65b0\u898f\u5fae\u751f\u7269\u8cc7\u6e90\u3000<\/strong><\/p>\n<\/div>\n\n\n\n

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\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c\u3000<\/strong><\/h2>\n\n\n\n
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\uff11\uff0e\u7c98\u6db2\u7d30\u83cc\u306e\u30b7\u30b0\u30ca\u30eb\u7269\u8cea\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n\n

\u751f\u7269\u306f\u74b0\u5883\u306e\u5909\u5316\u304c\u8d77\u3053\u308b\u3068\u30b7\u30b0\u30ca\u30eb\u7269\u8cea\u3092\u751f\u7523\u3057\u3066\u3001\u74b0\u5883\u306e\u5909\u5316\u306b\u9069\u5fdc\u3059\u308b\u3088\u3046\u306b\u306a\u308b\u3002\u3057\u304b\u3057\u3001\u7d30\u83cc\u306b\u304a\u3051\u308b\u666e\u904d\u7684\u306a\u30b7\u30b0\u30ca\u30eb\u7269\u8cea\u3068\u3057\u3066\u306f\u30a2\u30df\u30ce\u9178\u98e2\u9913\u6642\u306b\u4f5c\u3089\u308c\u308bppGpp\u3057\u304b\u8a8d\u77e5\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n<\/div>\n\n\n\n

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\u3000\u305d\u3053\u3067\u751f\u7269\u5168\u822c\u306b\u304a\u3044\u3066\u30a2\u30df\u30ce\u9178\u98e2\u9913\u6642\u306b\u4f5c\u3089\u308c\u308b\u30a2\u30c7\u30ce\u30b7\u30f3\u30dd\u30ea\u30ea\u30f3\u9178(ApnA\uff1an=3-6)\u3068\u6570\u5341\u304b\u3089\u6570\u5343\u306e\u30ea\u30f3\u9178\u304c\u91cd\u5408\u3057\u305f\u30dd\u30ea\u30ea\u30f3\u9178\u304c\u3001\u7c98\u6db2\u7d30\u83cc\u306e\u3069\u306e\u3088\u3046\u306a\u9175\u7d20\u306b\u3088\u3063\u3066\u5408\u6210\u53ca\u3073\u5206\u89e3\u3055\u308c\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u305d\u308c\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u7269\u8cea\u3092\u5408\u6210\u30fb\u5206\u89e3\u3059\u308b\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u7834\u58ca\u682a\u3092\u4f5c\u88fd\u3057\u3001\u305d\u308c\u3089\u306e\u9175\u7d20\u53ca\u3073\u30b7\u30b0\u30ca\u30eb\u7269\u8cea\u306e\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

\u3000\u4e00\u65b9\u3001\u305d\u308c\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u7269\u8cea\u306fATP\u306e\u5408\u6210\u57fa\u8cea\u306b\u306a\u308b\u3068\u3044\u3046\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u304d\u3066\u3044\u308b\u306e\u3067\u3001\u3053\u308c\u3089\u3092\u57fa\u8cea\u3068\u3057\u305f\u98e2\u9913\u6642\u306eATP\u5408\u6210\u30b7\u30b9\u30c6\u30e0\u306b\u3064\u3044\u3066\u306e\u89e3\u660e\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

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\uff12\uff0eSorangium<\/em>\u5c5e\u306e\u81ea\u7136\u754c\u304b\u3089\u306e\u5206\u96e2\u3068\u6709\u7528\u7269\u8cea\u306e\u63a2\u7d22<\/strong><\/h2>\n\n\n\n

\u7d30\u83cc\u306e\u4e2d\u3067\u6700\u3082\u591a\u304f\u306e\u907a\u4f1d\u5b50\u3092\u6709\u3059\u308b\u3053\u3068\u304b\u3089\u65b0\u898f\u306a\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3092\u751f\u7523\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3082\u306e\u306e\u3001\u96e3\u57f9\u990a\u6027\u7d30\u83cc\u3067\u3042\u308b\u305f\u3081\u7d14\u5316\u304c\u96e3\u3057\u304f\u3001\u65e5\u672c\u3067\u306f\u5206\u96e2\u3055\u308c\u3066\u3044\u306a\u3044\u7c98\u6db2\u7d30\u83cc\u306e\u5206\u96e2\u53ca\u3073\u7d14\u5316\u65b9\u6cd5\u3092\u78ba\u7acb\u3057\u3001\u653e\u7dda\u83cc\u306b\u66ff\u308f\u308b\u65b0\u3057\u3044\u5fae\u751f\u7269\u8cc7\u6e90\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u81ea\u7136\u754c\u304b\u3089\u7c98\u6db2\u7d30\u83cc\u3092\u5206\u96e2\u3057\u3066\u3044\u308b\u3002\u7c98\u6db2\u7d30\u83cc\u306e\u83cc\u682a\u3068\u57f9\u990a\u62bd\u51fa\u7269\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u3067\u3001\u4f01\u696d\u7b49\u306e\u5171\u540c\u7814\u7a76\u306b\u304a\u3044\u3066\u5275\u85ac\u306e\u305f\u3081\u306e\u65b0\u898f\u30ea\u30fc\u30c9\u5316\u5408\u7269\u306e\u63a2\u7d22\u3092\u884c\u3044\u305f\u3044\u3002<\/p>\n<\/div>\n\n\n\n

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\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>

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    \n
  • Kimura, Y. et al. (2017). High concentrations of intracellular Ap4A and\/or Ap5A in developing Myxococcus\u00a0xanthus<\/em>\u00a0cells inhibit sporulation. Microbiology 163:86-93.<\/li>\n\n\n\n
  • Oka, M. et al. (2016). Lysyl-tRNA synthetase from Myxococcus\u00a0xanthus<\/em>\u00a0catalyzes the formation of diadenosine penta- and\u3000hexaphosphates from adenosine tetraphosphate. Archieves of Biochemistry and Biophysics. 604:152-158.<\/li>\n\n\n\n
  • Sasaki, M. et al. (2014). Enzymatic characteristics of an ApaH-like phosphatase, PrpA, and a diadenosine tetraphosphate hydrolase, ApaH, from Myxococcus xanthus<\/em> enzymes. FEBS Letters 588:3395-3402.<\/li>\n\n\n\n
  • Kimura, Y. et al. (2012). Function analysis of a bacterial tyrosine kinase, BtkB, in Myxococcus xanthus<\/em>. FEMS<\/em> Microbiological Letters<\/em> 336(1):45-51 (2012).<\/li>\n\n\n\n
  • Mori, Y. et al. (2012). PhpA, a tyrosine phosphatase of Myxococcus xanthus<\/em>, is involved in the production of exopoly-saccharide. Microbiology<\/em>158(10):2546-2555.<\/li>\n\n\n\n
  • Kimura, Y. et al. (2011). A Myxococcus xanthus<\/em> bacterial tyrosine kinase, BtkA, is required for the formation of mature spores. Journal of Bacteriology<\/em> 193(20):5853-5857.<\/li>\n<\/ul>\n\n<\/div>
    \n\n
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    Research Area:\u3000<\/strong>Applied Life Science<\/mark><\/h2>\n\n\n\n

    Research Specialization:\u3000<\/strong>MicrobialPhysiology<\/mark>\u3000<\/strong><\/h2>\n\n\n\n

    Name:\u3000<\/strong>KIMURA, Yoshio<\/mark><\/h2>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    Keywords: Myxobacteria, signal transduction, ATP synthesis, \u00a0Novel microbial resources<\/p>\n<\/div>\n\n\n\n

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    \"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

    Recent Research<\/strong><\/h2>\n\n\n\n
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    1.\u00a0 Signal molecules of Myxobacteria.<\/strong><\/h2>\n\n\n\n

    \u00a0 When environmental conditions\u00a0become unfavorable,organisms produce signal molecules and can respond to changes in their environment.\u00a0\u00a0Diadenosine polyphosphate (Apn<\/sub>A; n=3-6) and polyphosphateare produced during amino acid-starvation. We try to identify and characterize key enzymes involved in these signal molecules of synthesis and degradation. Further, we generate\u00a0 gene-broken strains in which the enzyme genes are broken, and we will clarify the function of these enzymes and signal molecules.<\/p>\n<\/div>\n\n\n\n

    \n
    \"\"<\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n

    \u00a0\u00a0On the other hand, we are revealing that these signal molecules are substrates for ATP synthesis enzymes. We now studying that ATP synthesis system using these signal molecules under amino acid-starvation.<\/p>\n\n\n\n

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    2. Isolation of Sorangium<\/em> from the natural world andSearch for useful substances.<\/strong><\/h2>\n\n\n\n

    \u3000Gram-negative myxobacteria are an important source of novel classes of secondary metabolites. Of these, the genus\u00a0Sorangium<\/em>\u00a0is particularly valuable. Therefore, we are isolating the genus Sorangium<\/em> form soil.<\/p>\n\n\n\n

    \u00a0\u00a0 Natural products are extracted from Sorangium<\/em> cultures, and are provided for microbial growth inhibition experiments. In addition, the extracts are analyzed by LC-MS.\u00a0\u00a0\u00a0 \u3000<\/p>\n\n\n\n

    \u00a0 <\/strong> we are exploring useful substances from these cultures of Sorangium<\/em>.<\/p>\n<\/div>\n\n\n\n

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    Publications<\/strong><\/p>\n<\/div>

    \"\"<\/figure><\/div>\n\n\n\n
      \n
    • Kimura, Y. et al. (2017). High concentrations of intracellular Ap4A and\/or Ap5A in developing Myxococcus\u00a0xanthus<\/em>\u00a0cells inhibit sporulation. Microbiology 163:86-93.<\/li>\n\n\n\n
    • Oka, M. et al. (2016). Lysyl-tRNA synthetase from Myxococcus\u00a0xanthus<\/em>\u00a0catalyzes the formation of diadenosine penta- and\u3000hexaphosphates from adenosine tetraphosphate. Archieves of Biochemistry and Biophysics. 604:152-158.<\/li>\n\n\n\n
    • Sasaki, M. et al. (2014). Enzymatic characteristics of an ApaH-like phosphatase, PrpA, and a diadenosine tetraphosphate hydrolase, ApaH, from Myxococcus xanthus<\/em> enzymes. FEBS Letters 588:3395-3402.<\/li>\n\n\n\n
    • Kimura, Y. et al. (2012). Function analysis of a bacterial tyrosine kinase, BtkB, in Myxococcus xanthus<\/em>. FEMS<\/em> Microbiological Letters<\/em> 336(1):45-51 (2012).<\/li>\n\n\n\n
    • Mori, Y. et al. (2012). PhpA, a tyrosine phosphatase of Myxococcus xanthus<\/em>, is involved in the production of exopoly-saccharide. Microbiology<\/em>158(10):2546-2555.<\/li>\n\n\n\n
    • Kimura, Y. et al. (2011). A Myxococcus xanthus<\/em> bacterial tyrosine kinase, BtkA, is required for the formation of mature spores. Journal of Bacteriology<\/em> 193(20):5853-5857.<\/li>\n<\/ul>\n\n<\/div><\/div>\n\t\t<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":15782,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-3093","research","type-research","status-publish","has-post-thumbnail","hentry","research_category-184","center_category-260","sdgs_category-12"],"uagb_featured_image_src":{"full":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura-150x86.jpg",150,86,true],"medium":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"medium_large":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"large":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"1536x1536":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"2048x2048":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"gb-block-post-grid-landscape":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"gb-block-post-grid-square":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false],"post-thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/kimura.jpg",211,86,false]},"uagb_author_info":{"display_name":"\u7ba1\u7406\u8005","author_link":"https:\/\/www.ag.kagawa-u.ac.jp\/?author=1"},"uagb_comment_info":0,"uagb_excerpt":null,"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3093","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3093"}],"version-history":[{"count":46,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3093\/revisions"}],"predecessor-version":[{"id":32744,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3093\/revisions\/32744"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/15782"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3093"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}