{"id":3242,"date":"2012-01-23T16:50:07","date_gmt":"2012-01-23T07:50:07","guid":{"rendered":"http:\/\/www.ag.kagawa-u.ac.jp?post_type=research&p=3242"},"modified":"2024-05-09T11:39:06","modified_gmt":"2024-05-09T02:39:06","slug":"%e7%94%b0%e4%b8%ad-%e7%9b%b4%e5%ad%9d","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e7%94%b0%e4%b8%ad-%e7%9b%b4%e5%ad%9d","title":{"rendered":"\u7530\u4e2d\u3000\u76f4\u5b5d"},"content":{"rendered":"\n\n<\/map>\n\n\n<\/map>\n\n
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\u9818\u57df\u540d\u3000\u751f\u547d\u6a5f\u80fd\u79d1\u5b66<\/mark><\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000\u3000 \u7530\u3000\u4e2d\u3000\u76f4\u3000\u5b5d<\/mark><\/strong><\/h2>\n<\/div>\n\n\n\n
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\u7814\u7a76\u5206\u91ce\u3000\u5fdc\u7528\u5fae\u751f\u7269\u5b66<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
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\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u5206\u88c2\u9175\u6bcd\u3001\u30b4\u30eb\u30b8\u4f53\u3001\u5206\u6ccc\u7d4c\u8def\u3001\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30a2\u30b0\u30de\u30c1\u30f3<\/strong><\/p>\n<\/div>\n\n\n\n

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\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c<\/strong><\/h2>\n\n\n\n

1. \u7cd6\u9396\u3092\u4ecb\u3057\u305f\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8f38\u9001\u5236\u5fa1<\/h2>\n\n\n\n

\u3000<\/strong>\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u5c0f\u80de\u4f53\u3067\u8f38\u9001\u5c0f\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u30b4\u30eb\u30b8\u4f53\u3092\u901a\u904e\u3057\u3001\u7d30\u80de\u8868\u9762\u3084\u9069\u3057\u305f\u30aa\u30eb\u30ac\u30cd\u30e9\u3078\u3068\u904b\u3070\u308c\u308b\u3002\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u7cd6\u9396\u4fee\u98fe\u306f\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u54c1\u8cea\u7ba1\u7406\u3084\u9069\u5207\u306a\u5c0f\u80de\u3078\u306e\u30d1\u30c3\u30b1\u30fc\u30b8\u30f3\u30b0\u306b\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u7279\u7570\u7684\u306a\u7cd6\u9396\u3068\u7d50\u5408\u3059\u308b\u30ec\u30af\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9078\u5225\u8f38\u9001\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u304c\u3001\u8f38\u9001\u3055\u308c\u308b\u30ab\u30fc\u30b4\uff08\u7a4d\u307f\u8377\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u533a\u5225\u3059\u308b\u6a5f\u69cb\u3084\u5c40\u5728\u5316\u6a5f\u69cb\u306b\u95a2\u3057\u3066\u306f\u4e0d\u660e\u306a\u90e8\u5206\u304c\u591a\u3044\u3002\u79c1\u9054\u306f\u5206\u88c2\u9175\u6bcd\u306e\u30ec\u30af\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7834\u58ca\u682a\u304c\u793a\u3059\u8868\u73fe\u578b\u306e\u89e3\u6790\u304b\u3089\u3001\u30ec\u30af\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u89e3\u660e\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

2. \u5206\u88c2\u9175\u6bcd\u306e\u30b4\u30eb\u30b8\u4f53\u5c64\u677f\u5f62\u6210\u6a5f\u69cb\u306e\u89e3\u6790<\/h2>\n\n\n\n

\u3000\u5206\u88c2\u9175\u6bcd\u306e\u30b4\u30eb\u30b8\u4f53\u306f\u3001\u7d30\u80de\u5185\u306b10\u304b\u308920\u500b\u7a0b\u5ea6\u306e\u30c9\u30c3\u30c8\u72b6\u3068\u3057\u3066\u6563\u5728\u3057\u3066\u3044\u308b\u3002\u4e00\u3064\u4e00\u3064\u306e\u30b4\u30eb\u30b8\u4f53\u306b\u306f\u660e\u78ba\u306a\u5c64\u677f\u69cb\u9020\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u304c\u3001\u5c64\u677f\u5f62\u6210\u6a5f\u69cb\u3060\u3051\u3067\u306a\u304f\u3001\u30b4\u30eb\u30b8\u4f53\u306e\u6570\u3084\u7d30\u80de\u5185\u3067\u306e\u4f4d\u7f6e\u6c7a\u5b9a\u306b\u95a2\u308f\u308b\u6a5f\u69cb\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u3002\u79c1\u9054\u306f\u30b4\u30eb\u30b8\u4f53\u819c\u306e\u8868\u5728\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u7b49\u306b\u6ce8\u76ee\u3057\u3001\u30b4\u30eb\u30b8\u4f53\u6a5f\u80fd\u3078\u306e\u95a2\u308f\u308a\u3092\u89e3\u6790\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

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3. \u5206\u88c2\u9175\u6bcd\u306e\u30a2\u30b0\u30de\u30c1\u30f3\u3092\u4ecb\u3057\u305f\u30dd\u30ea\u30a2\u30df\u30f3\u751f\u5408\u6210\u7d4c\u8def\u306e\u89e3\u6790<\/h2>\n\n\n\n

\u3000\u30dd\u30ea\u30a2\u30df\u30f3\u306f\u69d8\u3005\u306a\u751f\u7269\u3067\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u7269\u8cea\u3067\u3042\u308b\u3002\u30aa\u30eb\u30cb\u30c1\u30f3\u3092\u4ecb\u3057\u305f\u7d4c\u8def\u3067\u306f\u7121\u304f\u3001\u30a2\u30b0\u30de\u30c1\u30f3\u3092\u4ecb\u3057\u305f\u30dd\u30ea\u30a2\u30df\u30f3\u751f\u5408\u6210\u7d4c\u8def\u306e\u751f\u7406\u7684\u5f79\u5272\u3084\u30a2\u30b0\u30de\u30c1\u30f3\u306e\u7269\u8cea\u3068\u3057\u3066\u306e\u6a5f\u80fd\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u3002\u79c1\u9054\u306f\u3001\u30a2\u30b0\u30de\u30c1\u30f3\u306e\u4ee3\u8b1d\u7d4c\u8def\u3092\u963b\u5bb3\u3057\u305f\u907a\u4f1d\u5b50\u7834\u58ca\u682a\u306e\u8868\u73fe\u578b\u3092\u6307\u6a19\u306b\u3001\u751f\u547d\u6a5f\u80fd\u3078\u306e\u95a2\u4e0e\u3092\u89e3\u660e\u3057\u3066\u3044\u308b\u3002<\/p>\n<\/div>\n\n\n\n

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\u3088\u308a\u8a73\u3057\u304f\u77e5\u308a\u305f\u3044\u65b9\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/mark><\/a><\/p>\n\n\n\n

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\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>

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  • Suzuki, S. et al. (2010) Characterization of two different types of UDP-glucose\/-galactose 4-epimerase involved in galactosylation in fission yeast. Microbiology 156: 708\u2013718.<\/li>\n\n\n\n
  • Tanaka, N., et al. (2001) Functional characterization of Gms1p\/UDP-galactose transporter in Schizosaccharomyces<\/em> pombe<\/em>. Yeast 18: 745-757.<\/li>\n<\/ul>\n\n\n\n

    <\/p>\n\n<\/div>

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    Research Area:\u3000<\/strong>Life Science & Biotechnology<\/mark><\/h2>\n\n\n\n

    Research Specialization:\u3000<\/strong>Applied Microbiology<\/mark><\/h2>\n\n\n\n

    Name:\u3000<\/strong>TANAKA, Naotaka<\/mark><\/h2>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    Keywords\uff1a fission yeast\uff0cGolgi apparatus, secretory pathway\uff0cagmatine,glycoprotein<\/p>\n<\/div>\n\n\n\n

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    Recent Research<\/strong><\/h2>\n\n\n\n

    1. Transport control of glycoproteins by lectin-like protein<\/h2>\n\n\n\n

    Secreted proteins and membrane proteins are entrapped in transport vesicles in the endoplasmic reticulum, passed through the Golgi apparatus, and transported to the cell surface and suitable organelles. It is known that glycosylation, which is one of posttranslational modifications, is essential for quality control of secreted proteins and packaging in appropriate vesicles. It has been clarified that lectin-like proteins are involved in protein sorting and transport by binding to specific sugar chains, but there are many unclear points about the mechanism that distinguishes cargo proteins and the localization mechanism of lectin-like proteins. We analyze the function of lectin – like protein by analyzing the phenotype indicated by the deficient strain of fission yeast lectin-like protein.<\/p>\n\n\n\n

    2. Analysis of the Golgi apparatus formation mechanism in fission yeast<\/h2>\n\n\n\n

    The Golgi apparatus of fission yeast is scattered in the form of about 10 to 20 dots in the cell. There is a clear layer in each Golgi apparatus, but not only the layer formation mechanism, but also the mechanisms involved in determining the number of Golgi apparatus and position within the cell are not well understood. We focus on the peripheral proteins of the Golgi apparatus and analyze the relationship to the Golgi apparatus function.<\/p>\n\n\n\n

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    3. Analysis of polyamine biosynthetic pathway via agmatine in fission yeast<\/h2>\n\n\n\n

    Polyamines are involved in cell function in various organisms. Ornithine-mediated pathways are well known, but the physiological role of agmatine-mediated polyamine biosynthesis pathway is relatively unknown. We are trying to clarify the involvement in cell function by inhibiting the metabolic pathway of agmatine.<\/p>\n<\/div>\n\n\n\n

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    Publications<\/strong><\/p>\n<\/div>

    \"\"<\/figure><\/div>\n\n\n\n
      \n
    • Suzuki, S. et al. (2010) Characterization of two different types of UDP-glucose\/-galactose 4-epimerase involved in galactosylation in fission yeast. Microbiology 156: 708\u2013718.<\/li>\n\n\n\n
    • Tanaka, N., et al. (2001) Functional characterization of Gms1p\/UDP-galactose transporter in Schizosaccharomyces<\/em> pombe<\/em>. Yeast 18: 745-757.<\/li>\n<\/ul>\n\n<\/div><\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":15778,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_uag_custom_page_level_css":"","ub_ctt_via":"","footnotes":""},"class_list":["post-3242","research","type-research","status-publish","has-post-thumbnail","hentry","research_keyword-208","research_keyword-195","research_keyword-209","research_keyword-210","research_category-184","center_category-260","center_category-259","sdgs_category-15","sdgs_category-12"],"uagb_featured_image_src":{"full":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka.jpg",360,270,false],"thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka-150x150.jpg",150,150,true],"medium":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka-300x225.jpg",300,225,true],"medium_large":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka.jpg",360,270,false],"large":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka.jpg",360,270,false],"1536x1536":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka.jpg",360,270,false],"2048x2048":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka.jpg",360,270,false],"gb-block-post-grid-landscape":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka.jpg",360,270,false],"gb-block-post-grid-square":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka.jpg",360,270,false],"post-thumbnail":["https:\/\/www.ag.kagawa-u.ac.jp\/wp-content\/uploads\/2012\/01\/tanaka-360x198.jpg",360,198,true]},"uagb_author_info":{"display_name":"\u7ba1\u7406\u8005","author_link":"https:\/\/www.ag.kagawa-u.ac.jp\/?author=1"},"uagb_comment_info":0,"uagb_excerpt":null,"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3242"}],"version-history":[{"count":63,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3242\/revisions"}],"predecessor-version":[{"id":32740,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3242\/revisions\/32740"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/15778"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}