{"id":3631,"date":"2012-01-25T10:14:37","date_gmt":"2012-01-25T01:14:37","guid":{"rendered":"http:\/\/www.ag.kagawa-u.ac.jp?post_type=research&p=3631"},"modified":"2024-05-09T11:07:46","modified_gmt":"2024-05-09T02:07:46","slug":"%e5%90%89%e5%8e%9f%e6%98%8e%e7%a7%80%e3%80%80%ef%bc%88%e9%85%b5%e7%b4%a0%e5%88%a9%e7%94%a8%e5%ad%a6%ef%bc%89","status":"publish","type":"research","link":"https:\/\/www.ag.kagawa-u.ac.jp\/?research=%e5%90%89%e5%8e%9f%e6%98%8e%e7%a7%80%e3%80%80%ef%bc%88%e9%85%b5%e7%b4%a0%e5%88%a9%e7%94%a8%e5%ad%a6%ef%bc%89","title":{"rendered":"\u5409\u539f\u3000\u660e\u79c0"},"content":{"rendered":"
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\u65e5\u672c\u8a9e<\/div><\/div>
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\u9818\u57df\u540d\u3000\u3000\u98df\u54c1\u79d1\u5b66<\/mark><\/strong><\/h2>\n\n\n\n

\u6559\u54e1\u6c0f\u540d\u3000\u3000 \u5409\u3000\u539f\u3000\u660e\u3000\u79c0<\/mark><\/strong><\/h2>\n<\/div>\n\n\n\n
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\u7814\u7a76\u5206\u91ce\u3000\u9175\u7d20\u5229\u7528\u5b66<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n
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\u7814\u7a76\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u5e0c\u5c11\u7cd6\uff0c\u5fae\u751f\u7269\uff0c\u9175\u7d20<\/strong><\/p>\n<\/div>\n\n\n\n

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\u6700\u8fd1\u306e\u7814\u7a76\u8ab2\u984c\u3000<\/strong><\/h2>\n\n\n\n
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\uff11\uff0e\u81ea\u7136\u754c\u304b\u3089\u65b0\u898f\u9175\u7d20\u304a\u3088\u3073\u65b0\u898f\u5fae\u751f\u7269\u306e\u63a2\u7d22\u3068\u305d\u308c\u3089\u3092\u7528\u3044\u305f\u5e0c\u5c11\u7cd6\u751f\u7523<\/strong><\/h2>\n\n\n\n

\u3000\u8eab\u306e\u56de\u308a\u306b\u6570\u591a\u304f\u5b58\u5728\u3059\u308b\u5fae\u751f\u7269\u306f\u3001\u69d8\u3005\u306a\u9175\u7d20\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u81ea\u7136\u754c\u306b\u591a\u91cf\u306b\u5b58\u5728\u3059\u308b\u5358\u7cd6\u304b\u3089\u3001\u81ea\u7136\u754c \u306b\u5fae\u91cf\u306b\u3057\u304b\u5b58\u5728\u3057\u306a\u3044\u5e0c\u5c11\u7cd6\u306b\u8ee2\u63db\u3067\u304d\u308b\u65b0\u898f\u5fae\u751f\u7269\u3084\u65b0\u898f\u9175\u7d20\u3092\u63a2\u7d22\u3057\u307e\u3059\u3002\u5f97\u3089\u308c\u305f\u5fae\u751f\u7269\u3084\u9175\u7d20\u3092\u7528\u3044\u3066\u69d8\u3005\u306a\u5e0c\u5c11\u7cd6\u306e\u751f\u7523\u3092\u884c\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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\uff12\uff0e\u69d8\u3005\u306a\u5fae\u751f\u7269\u3084\u9175\u7d20\u3092\u7528\u3044\u305f\u30c7\u30aa\u30ad\u30b7\u5e0c\u5c11\u7cd6\u306e\u751f\u7523\u3000<\/strong><\/h2>\n\n\n\n

\u3000<\/strong>\u5e0c\u5c11\u7cd6\u306e\u751f\u7523\u306f\u3001\u30a2\u30eb\u30c9\u30fc\u30b9\u30fb\u30b1\u30c8\u30fc\u30b9\u9593\u306e\u7570\u6027\u5316\u53cd\u5fdc\u3001\u30b1\u30c8\u30fc\u30b9\u30fb\u30b1\u30c8\u30fc\u30b9\u9593\u306e\u30a8\u30d4\u5316\u53cd\u5fdc\u3001\u30dd\u30ea\u30aa\u30fc\u30eb\u30fb\u30b1\u30c8\u30fc\u30b9\u9593\u306e\u9178\u5316\u9084\u5143\u53cd\u5fdc\u3001\u30dd\u30ea\u30aa\u30fc\u30eb\u30fb\u30a2\u30eb\u30c9\u30fc\u30b9\u9593\u306e\u9178\u5316\u53cd\u5fdc\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u751f\u7406\u6d3b\u6027\u3092\u6709\u3059\u308b\u65b0\u305f\u306a\u5e0c\u5c11\u7cd6\u306e\u751f\u7523\u3092\u76ee\u6307\u3057\u3001\u51fa\u767a\u539f\u6599\u306b\u30c7\u30aa\u30ad\u30b7\u7cd6\u3092\u7528\u3044\u3066\u69d8\u3005\u306a\u9175\u7d20\u53cd\u5fdc\u3092\u884c\u3044\u65b0\u898f\u30c7\u30aa\u30ad\u30b7\u5e0c\u5c11\u7cd6\u306e\u751f\u7523\u3092\u884c\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u3000<\/strong><\/p>\n<\/div>\n\n\n\n

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\uff13\uff0e\u6709\u6a5f\u5408\u6210\u5316\u5408\u7269\u304b\u3089\u5e0c\u5c11\u7cd6\u8a98\u5c0e\u4f53\u306e\u751f\u7523\u306b\u95a2\u3059\u308b\u7814\u7a76<\/strong><\/h2>\n\n\n\n

\u3000\u6709\u6a5f\u5408\u6210\u306e\u624b\u6cd5\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u81ea\u7136\u754c\u306b\u5b58\u5728\u3057\u306a\u3044\u7cd6\u8cea\u304c\u5408\u6210\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u3092\u51fa\u767a\u539f\u6599\u3068\u3057\u3066\u3001\u5fae\u751f\u7269\u3084\u9175\u7d20\u3092\u4f7f\u3046\u4e8b\u3067\u3001\u751f\u7406\u4f5c\u7528\u3092\u6301\u3064\u65b0\u3057\u3044\u7cd6\u8cea\u304c\u751f\u7523\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u8840\u7cd6\u5024\u4e0a\u6607\u6291\u5236\u52b9\u679c\u306a\u3069\u304c\u77e5\u3089\u308c\u308b16\u7a2e\u985e\u306e\u30ce\u30b8\u30ea\u30de\u30a4\u30b7\u30f3\u306e\u7570\u6027\u4f53\u3092\u751f\u7523\u3057\u3066\u3044\u307e\u3059<\/p>\n<\/div>\n\n\n\n

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\u4ee3\u8868\u7684\u306a\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n<\/div>

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  • Akihide Yoshihara  et al. (2013) Isomerization of deoxyhexoses: green bioproduction of 1-deoxy-D-tagatose from L-fucose  and of 6-deoxy-D-tagatose from D-fucose using Enterobacteragglomerans<\/em> strain 221e, Tetrahedron: Asymmetry, 19 (6), 739-745<\/li>\n\n\n\n
  • Pushpakiran Gullapalli et al. (2010) Conversion of L-rhamnose into ten of the sixteen 1- and 6-deoxyketohexoses in water with three reagents: D-tagatose-3-epimerase equilibrates C3 epimers of deoxyketoses, Tetrahedron Letters<\/em>,  51 (6), 895-898<\/li>\n\n\n\n
  • Devendar Rao et al. (2009) A concise approach to the synthesis of all twelve 5-deoxyhexoses: D-tagatose-3-epimerase\u2014a reagent that is both specific and general, Tetrahedron Letters, 50 (26), 3559-3563<\/li>\n\n\n\n
  • Andreas F. G. Glawar et al. (2013) An approach to 8 stereoisomers of homonojirimycin from D-glucose via kinetic &   \u3000\u3000thermodynamic azido-\u03b3-lactones, Organic & Biomolecular Chemistry<\/em>, 11 (40), 6886-6899<\/li>\n<\/ul>\n\n<\/div>
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    Research Area:\u3000<\/strong>Food Science<\/mark>\u3000
    <\/strong>Research Specialization:\u3000<\/strong>Applied enzymology<\/mark>\u3000
    <\/strong>Name:\u3000<\/strong>YOSHIHARA, Akihide<\/mark><\/h2>\n\n\n\n
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    Keywords\uff1aRare sugar, Microbe, Enzyme<\/p>\n<\/div>\n\n\n\n

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    Recent Research<\/strong><\/h2>\n\n\n\n
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    1. Screening of microbe and enzyme. Production of rare sugars using their microbe and enzymes<\/strong><\/h2>\n\n\n\n

    Microbe produces a lot of enzymes. Rare sugars are produced by their biotransformation. Therefore many researchers isolate microbe for effective production of  rare sugars. In this research, We screen various rare sugar producing microbes and enzymes. Optimum condition determine for rare sugar production, We try to produce a lot of rare sugars  <\/p>\n<\/div>\n\n\n\n

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    2. Production of rare sugar derivatives using microbial and enzymatic reaction<\/strong><\/h2>\n\n\n\n

    Rare sugars are produced by several enzymes. These enzymes are able to classify into following  four groups.<\/p>\n\n\n\n

    \u30fbIsomerase catalyzes reversible aldose-ketose isomerization<\/p>\n\n\n\n

    \u30fbEpimerase catalyzes reversible ketose C-3 epimerization.<\/p>\n\n\n\n

    \u30fbDehydrogenase catalyzes the oxidation of polyols to corresponding ketoses.<\/p>\n\n\n\n

    \u30fbOxidase catalyzes the oxidation of polyols to corresponding aldoses.<\/p>\n\n\n\n

    In this research, we try to produce novel rare sugar derivatives that have physiologically activity by microbial and enzymatic reactions. We focus to deoxy monosaccharides, azido monosaccharides and their derivatives.<\/p>\n<\/div>\n\n\n\n

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    Publications<\/strong><\/p>\n<\/div>

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    • Akihide Yoshihara  et al. (2013) Isomerization of deoxyhexoses: green bioproduction of 1-deoxy-D-tagatose from L-fucose  and of 6-deoxy-D-tagatose from D-fucose using Enterobacteragglomerans<\/em> strain 221e, Tetrahedron: Asymmetry, 19 (6), 739-745<\/li>\n\n\n\n
    • Pushpakiran Gullapalli et al. (2010) Conversion of L-rhamnose into ten of the sixteen 1- and 6-deoxyketohexoses in water with three reagents: D-tagatose-3-epimerase equilibrates C3 epimers of deoxyketoses, Tetrahedron Letters<\/em>,  51 (6), 895-898<\/li>\n\n\n\n
    • Devendar Rao et al. (2009) A concise approach to the synthesis of all twelve 5-deoxyhexoses: D-tagatose-3-epimerase\u2014a reagent that is both specific and general, Tetrahedron Letters, 50 (26), 3559-3563<\/li>\n\n\n\n
    • Andreas F. G. Glawar et al. (2013) An approach to 8 stereoisomers of homonojirimycin from D-glucose via kinetic &  thermodynamic azido-\u03b3-lactones, Organic & Biomolecular Chemistry<\/em>, 11 (40), 6886-6899<\/li>\n<\/ul>\n\n<\/div><\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":15767,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","ub_ctt_via":"","footnotes":""},"class_list":["post-3631","research","type-research","status-publish","has-post-thumbnail","hentry","research_keyword-135","research_keyword-195","research_keyword-163","research_category-217","center_category-258","center_category-259","sdgs_category-6","sdgs_category-15","sdgs_category-5"],"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3631","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3631"}],"version-history":[{"count":30,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3631\/revisions"}],"predecessor-version":[{"id":32727,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/research\/3631\/revisions\/32727"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/15767"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3631"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}