研究業績

2010
  • フラビン含有アミノ酸脱水素酵素の機能開発
    アミノ酸研究, 3, 29-38, 2010.03
    大島敏久; 川上竜巳; 櫻庭春彦

  • First Crystal Structure of l-Lysine 6-Dehydrogenase as an NAD-dependent Amine Dehydrogenase
    Journal of Biological Chemistry., 285, 8444-8453, 2010.01
    Kazunari Yoneda; Junya Fukuda; Haruhiko Sakuraba; Toshihisa Ohshima


2009
  • 大腸菌で生産される超好熱菌由来の不活性型グルタミン酸脱水素酵素の活性化機構
    生化学, 81, 1049-1055, 2009.12
    郷田秀一郎; 櫻庭春彦; 大島敏久

  • A novel cytotoxic protein, Karatoxin, from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis.
    Toxin Reviews., 28, 260 - 265, 2009.11
    Kuniko Nagasaka; Hideyuki Nakagawa; Fumihiko Satoh; Takefumi Hosotani; Kumio Yokoigawa; Hitomi Sakai; Haruhiko Sakuraba; Toshihisa Ohshima; Mitsuko Shinohara; Kiyoshi Ohura

  • Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.
    Biochimica et Biophysica Acta., 1794, 1496-1504, 2009.06
    Ryushi Kawakami; Haruhiko Sakuraba; Shuichiro Goda; Hideaki Tsuge; Toshihisa Ohshima

  • An amperometric D-amino acid biosensor prepared with a thermostable D-proline dehydrogenase and a carbon nanotube-ionic liquid gel.
    Analytical Sciences., 25, 919-923, 2009.05
    Yuji Tani; Yukiko Itoyama; Kenichi Nishi; Chikahiro Wada; Yoshio Shoda; Takenori Satomura; Haruhiko Sakuraba; Toshihisa Ohshima; Yukako Hayashi; Tomoki Yabutani; Junko Motonaka

  • Development of a novel immobilization method for enzymes from hyperthermophiles.
    Biotechnology Letters., 31, 1037-1041, 2009.03
    Kosuke Minamihata; Masamichi Tokunaga; Noriho Kamiya; Shiro Kiyoyama; Haruhiko Sakuraba; Toshihisa Ohshima; Masahiro Goto

  • 超好熱性アーキアのユニークな糖代謝系.
    蛋白質 核酸 酵素., 54, 134-140, 2009.02
    大島敏久; 櫻庭春彦

  • 超好熱性アーキアのフラビン含有アミノ酸脱水素酵素の機能と構造、及び応用.
    日本応用酵素協会誌., 43, 33-44, 2009.02
    大島敏久; 櫻庭春彦; 川上竜巳; 里村武範; 津下英明

  • Structure of a D-tagatose 3-epimerase-related protein from the hyperthermophilic bacterium Thermotoga maritima.
    Acta Crystallographica., F65, 199-203, 2009.01
    Haruhiko Sakuraba; Kazunari Yoneda; Takenori Satomura; Ryushi Kawakami; Toshihisa Ohshima


 2008
  • A Novel Flavin Adenine Dinucleotide (FAD) Containing D-Lactate Dehydrogenase from the Thermoacidophilic Crenarchaeota Sulfolobus tokodaii Strain 7: Purification, Characterization and Expression in Escherichia coli.
    Journal of Bioscience and Bioengineering
    ., 106, 16-21, 2008.07
    Takenori Satomura;Ryushi Kawakami; Haruhiko Sakuraba
    ; Toshihisa Ohshima
  • Development of a D-amino acids electrochemical sensor based on immobilization of thermostable D-proline dehydrogenase within agar gel membrane.
    Analytica Chimica Acta., 619, 215-220, 2008.07
    Yuji Tani; KatsuhitoTanaka; Tomoki Yabutani; Yuji Mishima; Haruhiko Sakuraba; Toshihisa Ohshima; Junko Motonaka

  • 大腸菌体内で不活性型遺伝子組換え酵素として生産される好熱菌由来のグルタミン酸脱水素酵素の活性化とそれに伴う構造変化.
    ビタミン, 82, 337-343, 2008.06
    郷田秀一郎; 櫻庭春彦; 柊 弓絃; 大島敏久

  • Crystal structure of an archaeal alanine:glyoxylate aminotransferase.
    Acta Crystallographica., D64, 696-699, 2008.06
    Haruhiko Sakuraba; Kazunari Yoneda; Kiyo Takeuchi; Hideaki Tsuge; Nobuhiko Katunuma; Toshihisa Ohshima

  • Structure of L-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii.
    Biochim Biophys Acta
    ., 1784, 563-571, 2008.05
    Haruhiko Sakuraba; Kazunari Yoneda; Issaku Asai; Hideaki Tsuge; Nobuhiko Katunuma; Toshihisa Ohshima

  • 超好熱菌アルドラーゼが触媒するアルドール縮合反応.
    日本生物工学会誌., 86, 165-167, 2008.04
    櫻庭春彦; 大島敏久

  • Molecular and functional characterization of D-3-phosphoglycerate dehydrogenase in the serine biosynthetic pathway of the hyperthermophilic archaeon Sulfolobus tokodaii.
    Archives of Biochemistry and Biophysics
    ., 470, 120-128, 2008.02
    Yasuhiro Shimizu; Haruhiko Sakuraba; Katsumi Doi; Toshihisa Ohshima



 2007
  • Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-D-ribose-5-phosphate aldolase.
    Applied and Environmental Microbiology
    ., 73, 7427-7434, 2007.11
    Haruhiko Sakuraba; Kazunari Yoneda; Kumiko Yoshihara; Kyoko Satoh; RyushiKawakami; Yoshihiro Uto; Hideaki Tsuge; Katsuyuki Takahashi; Hitoshi Hori; Toshihisa Ohshima

  • Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase-NAD-citrate ternary complex. Federation of European Biochemical Societies journal., 274, 4315-4325, 2007.08
    Kazunari Yoneda; Haruhiko Sakuraba; Hideaki Tsuge; Nobuhiko Katunuma; Toshihisa Ohshima

  • Gene cloning and characterization of the very large NAD-dependent L-glutamate dehydrogenase from the psychrophile Janthinobacterium lividum, isolated from cold soil.
    Journal of Bacteriology
    ., 189, 5626-5633, 2007.08
    Ryushi Kawakami; Haruhiko Sakuraba; Toshihisa Ohshima

  • Gene expression and characterization of 2-keto-3-deoxygluconate kinase, a key enzyme in the modified Entner-Doudoroff pathway of the aerobic and acidphilic hyperthermophile Sulfolobus tokodaii.
    Protein Expression and Purification
    ., 54, 73-78, 2007.07
    Toshihisa Ohshima; Ryushi Kawakami; Yuichiro Kanai; Shuichiro Goda; Haruhiko Sakuraba

  • An enzymatic cycling assay for nicotinic acid adenine dinucleotide phosphate using NAD synthetase.
    Analytical Biochemistry
    ., 364, 97-103, 2007.05
    Fumihiko Yamaguchi; Toshihisa Ohshima; Haruhiko Sakuraba

  • Comparative analysis of the protein folding activities of two chaperonin subunits of Thermococcus strain KS-1; the effects of beryllium fluoride.
    Extremophiles
    ., 11, 225-235, 2007.03
    Takao Yoshida; Ryo Iizuka; Keisuke Itami; Takuo Yasunaga; Haruhiko Sakuraba; Toshihisa Ohshima; Masafumi Yohda; Tadashi Maruyama

  • 超好熱菌由来新規色素依存性L-プロリン脱水素酵素の機能および構造解析とバイオセンサーへの応用.
    2005医科学応用研究財団研究報告., 24, 57-60, 2007.02
    櫻庭春彦

  • Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: contribution of cross-domain polar networks to thermostability.
    Journal of Molecular Biology
    ., 365, 362-378, 2007.01
    Hitoshi Nakayama; Tatsuro Shimamura; Takahito Imagawa; Nobuaki Shirai; Takashi Itoh; Yoshihiko Sako; Masashi Miyano; Haruhiko Sakuraba; Toshihisa Ohshima; Norimichi Nomura; Hideaki Tsuge



 2006
  • The first archaeal L-aspartate dehydrogenase from the hyperthermophile Archaeoglobus fulgidus: gene cloning and enzymological characterization.
    Biochimica et Biophysica Acta
    ., 1764, 1087-1093, 2006.06
    Kazunari Yoneda; Ryushi Kawakami; Yuya Tagashira; Haruhiko Sakuraba; Shuichiro Goda; Toshihisa Ohshima

  • 超好熱菌タンパク質の耐熱化の分子戦略.
    化学と生物., 44, 305-312, 2006.05
    櫻庭春彦; 郷田秀一郎; 川上竜巳; 大島敏久; 津下英明; 勝沼信彦

  • Bilirubin oxidase activity of Bacillus subtilis CotA.
    Applied and Environmental Microbiology
    ., 72, 972-975, 2006.01
    Shin-ichi Sakasegawa; Hidehiko Ishikawa; Shigeyuki Imamura; Haruhiko Sakuraba; Shuichiro Goda; Toshihisa Ohishima

  • 新規ダイフラビン酵素ファミリー: FAD, FMN, ATP結合L-プロリン脱水素酵素複合体.
    生化学., 78, 41-45, 2006.01
    津下英明; 川上竜巳; 櫻庭春彦; 安藝謙嗣; 勝沼信彦; 大島敏久



 2005
  • Intersubunit interaction induced by subunit rearrangement is essential for the catalytic activity of the hyperthermophilic glutamate dehydrogenase from Pyrobaculum islandicum.
    Biochemistry
    ., 44, 15304-15313, 2005.11
    Shuichiro Goda; Masaki Kojima; Yoshimi Nishikawa; Chizu Kujo; Ryushi Kawakami; Seiki Kuramitsu; Haruhiko Sakuraba; Yuzuru Hiragi; Toshihisa Ohshima

  • 超好熱アーキアの新規フラビン含有アミノ酸脱水素酵素の機能開発.
    酵素工学ニュース., 54, 31-36, 2005.10
    川上竜巳; 櫻庭春彦; 大島敏久

  • Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii.
    Journal of Biological Chemistry
    ., 280, 31045-31049, 2005.09
    Hideaki Tsuge; Ryushi Kawakami; Haruhiko Sakuraba; Hideo Ago; Masashi Miyano; Kenji Aki; Nobuhiko Katunuma; Toshihisa Ohshima

  • First archaeal inorganic polyphosphate/ATP-dependent NAD kinase, from hyperthermophilic archaeon Pyrococcus horikoshii: cloning, expression, and characterization.
    Applied and Environmental Microbiology
    ., 9, 317-324, 2005.08
    Haruhiko Sakuraba; Ryushi Kawakami; Toshihisa Ohshima

  • L-Threonine dehydrogenase from the hyperthermophilic archaeon Pyrococcus horikoshii OT3: gene cloning and enzymatic characterization.
    Extremophiles
    ., 71, 4352-4358, 2005.08
    Yasuhiro Shimizu; Haruhiko Sakuraba; Ryushi Kawakami; Shuichiro Goda; Yutaka Kawarabayasi; Toshihisa Ohshima

  • A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3.
    Federation of European Biochemical Societies journal
    ., 272, 4044-4054, 2005.08
    Ryushi Kawakami; Haruhiko Sakuraba; Hideaki Tsuge; Shuichiro Goda; Nobuhiko Katunuma; Toshihisa Ohshima

  • Crystal structure of the NAD biosynthetic enzyme quinolinate synthase.
    Journal of Biological Chemistry
    ., 280, 26645-26648, 2005.07
    Haruhiko Sakuraba; Hideaki Tsuge; Kazunari Yoneda; Nobuhiko Katunuma; Toshihisa Ohshima

  • The first crystal structure of an archaeal helical repeat protein.
    Acta Crystallographica
    ., F61, 636-639, 2005.07
    Kazunari Yoneda; Haruhiko Sakuraba; Hideaki Tsuge; Nobuhiko Katunuma; Seiki Kuramitsu; Takeshi Kawabata; Toshihisa Ohshima

  • 超好熱菌酵素を素子とするバイオセンサーの開発:ポリアミン関連酵素の機能解析とD-プロリン脱水素酵素機能電極センサーの開発.
    徳島大学工学部研究報告., 50, 33-40, 2005.05
    郷田秀一郎; 薮谷智規; 櫻庭春彦; 本仲純子; 大島 敏久

  • 超好熱菌由来アルドラーゼのユニークな4次構造と高度耐熱性.
    生物物理., 45, 97-100, 2005.04
    櫻庭春彦; 大島敏久; 津下英明; 勝沼信彦

  • The first archaeal agmatinase from anaerobic hyperthermophilic archaeon Pyrococcus horikoshii: cloning, expression, and characterization.
    Biochimica et Biophysica Acta
    ., 1748, 110-115, 2005.04
    Shuichiro Goda; Haruhiko Sakuraba; Yutaka Kawarabayasi; Toshihisa Ohshima

  • A new enzymatic cycling method for ammonia assay using NAD synthetase.
    Clinica Chimica Acta
    ., 352, 165-173, 2005.02
    Fumihiko Yamaguchi; Takashi Etoh; Mamoru Takahashi; Hideo Misaki; Haruhiko Sakuraba; Toshihisa Ohshima

  • The first crystal structure of hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.
    Journal of Molecular Biology
    ., 345, 325-337, 2005.01
    Mohammad W. Bhuiya; Haruhiko Sakuraba; Toshihisa Ohshima; Takahito Imagawa; Nobuhiko Katunuma; Hideaki Tsuge



 2004
  • Crystallization and preliminary X-ray diffraction analysis of homing endonuclease I-Tsp061I.
    Acta Crystallographica
    ., D60, 2006-2008, 2004.11
    Takahito Imagawa; Hitoshi Nakayama; Nobuhiko Katunuma; Haruhiko Sakuraba; Toshihisa Ohshima; Takashi Itoh; Yoshihiko Sako; Norimichi Nomura; Hideaki Tsuge

  • Oxidative stress response in an anaerobic hyperthermophilic archaeon: presence of a functional peroxiredoxin in Pyrococcus horikoshii.
    Journal of Biochemistry
    ., 136, 541-547, 2004.10
    Ryushi Kawakami; Haruhiko Sakuraba; Shintaro Kamohara; Shuichiro Goda; Yutaka Kawarabayasi; Toshihisa Ohshima

  • 超好熱菌の酵素の構造解析に基づく新規耐熱性酵素の創製.
    日本農芸化学会誌., 78, 761-763, 2004.08
    大島敏久; 櫻庭春彦; 津下英明

  • Novel archaeal alanine:glyoxylate aminotransferase from Thermococcus litoralis.
    Journal of Bacteriology
    ., 186, 5513-5518, 2004.08
    Haruhiko Sakuraba; Ryushi Kawakami; Hajime Takahashi; Toshihisa Ohshima

  • Crystallization and preliminary X-ray diffraction analysis of the hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.
    Acta Crystallographica
    ., 8, 99-108, 2004.04
    Mohammad W. Bhuiya; Haruhiko Sakuraba; Kazunari Yoneda; Toshihisa Ohshima; Takahito Imagawa; Nobuhiko Katunuma; Hideaki Tsuge

  • Gene and primary structures of dye-linked L-proline dehydrogenase from the hyperthermophilic archaeon Thermococcus profundus show the presence of a novel heterotetrameric amino acid dehydrogenase complex.
    Extremophiles
    ., D60, 715-717, 2004.04
    Ryushi Kawakami; Haruhiko Sakuraba; Toshihisa Ohshima

  • Unique sugar metabolism and novel enzymes of hyperthermophilic archaea.
    The Chemical Record
    ., 3, 281-287, 2004.03
    Haruhiko Sakuraba; S. Goda; T. Ohshima

  • Expression of foreign proteins in Escherichia coli by fusing with an archaeal FK506 binding protein.
    Applied Microbiology and Biotechnology
    ., 64, 99-105, 2004.03
    A. Ideno; M. Furutani; T. Iwabushi; T. Iida; Y. Iba; Y. Kurosawa; Haruhiko Sakuraba; T. Ohshima; Y. Kawarabayasi; T. Maruyama

  • Highly stable L-lisine 6-dehydrogenase from the thermophile Geobacillus stearothermophilus isolated from a Japanese hot spring: characterization, gene cloning and sequencing, and expression.
    Applied and Environmental Microbiology
    ., 70, 937-942, 2004.02
    Mojgan Heydari; Toshihisa Ohshima; Naoki Nunoura-Kominato; Haruhiko Sakuraba



 2003
  • The Sulfolobus tokodaii gene ST1704 codes highly thermostable glucose dehydrogenase.
    Journal of Molecular Catalysis B: Enzymatic
    ., 23, 273-279, 2003.09
    T. Ohshima; Y. Ito; Haruhiko Sakuraba; S. Goda; Y. Kawarabayasi

  • A nicotinamide mononucleotide adenylyltransferase with unique adenylyl group donor specificity from a hyperthermophilic archaeon, Pyrococcus horikoshii OT3.
    Journal of Molecular Catalysis B: Enzymatic
    ., 23, 281-289, 2003.09
    Haruhiko Sakuraba; Kyouhei Kanai; Shuichiro Goda; Yutaka Kawarabayasi; Toshihisa Ohshimai

  • 新奇解糖系—超好熱アーキアの変形Embden-Meyerhof経路と新規酵素.
    蛋白質 核酸 酵素., 48, 1256-1262, 2003.08
    櫻庭春彦; 大島敏久

  • The first crystal structure of archaeal aldolase: unique tetrameric structure of 2-deoxy-D-ribose-5-phosphate aldolase from the hyperthermophilic archaea Aeropyrum pernix.
    Journal of Biological Chemistry
    ., 278, 10799-10806, 2003.03
    Haruhiko Sakuraba; Hideaki Tsuge; Ikuko Shimoya; Ryushi Kawakami; Shuichiro Goda; Yutaka Kawarabayasi; Nobuhiko Katunuma; Hideo Ago; Masashi Miyano; Toshihisa Ohshima

  • Cloning, expression, and characterization of the first archaeal ATP-dependent glucokinase from aerobic hyperthermophilic archaeon Aeropyrum pernix.
    Journal of Biochemistry
    ., 133, 219-224, 2003.02
    Haruhiko Sakuraba; Yuri Mitani; Shuichiro Goda; Yutaka Kawarabayasi; Toshihisa Ohshima

  • 超好熱アーキア特有の解糖系路の酵素の解析とATP再生系.
    ビタミン., 77, 11-23, 2003.01
    櫻庭春彦

  • 最古の糖代謝系?—超好熱菌が持つユニークなエネルギー代謝—.
    日本生物工学会誌., 81, 20, 2003.01
    櫻庭春彦; 大島敏久



 2002
  • Fishing for bioactive substances from scorpionfish and some sea urchins.
    Journal of Natural Toxins
    ., 11, 297-304, 2002.12
    F. Satoh; H. Nakagawa; H. Yamada; K. Nagasaka; T. Nagasaka; Y. Araki; Y. Tomihara; M. Nozaki; Haruhiko Sakuraba; T. Ohshima; T. Hatakeyama; H. Aoyagi

  • Stable ammonia-specific NAD synthase from Bacillus stearothermophilus: purification, characterization, gene cloning and applications.
    Bioscience, Biotechnology, and Biochemistry
    ., 66, 2052-2059, 2002.10
    Fumihiko Yamaguchi; Shinji Koga; Issei Yoshioka; Mamoru Takahashi; Haruhiko Sakuraba; Toshihisa Ohshimai

  • Crystal structure of the ADP-dependent glucokinase from Pyrococcus horikoshii at 2.0-Å resolution: a large conformational change in ADP-dependent glucokinase.
    Protein Science
    ., 11, 2456-2463, 2002.10
    Hideaki Tsuge; Haruhiko Sakuraba; Toru Kobe; Akira Kujime; Nobuhiko Katunuma; Toshihisa Ohshima

  • L-Aspartate oxidase is present in the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii OT-3: characteristics and role in the de novo biosynthesis of nicotinamide adenine dinucleotide proposed by genome sequencing.
    Extremophiles
    ., 6, 275-281, 2002.08
    Haruhiko Sakuraba; Takenori Satomura; Ryushi Kawakami; Sanae Yamamoto; Yutaka Kawarabayashi; Hisasi Kikuchi; Toshihisa Ohshima

  • Crystallization and preliminary X-ray diffraction analysis of glutamate dehydrogenase from an aerobic hyperthermophilic archaeon, Aeropyrum pernix K1.
    Acta Crystallographica
    ., D58, 1338-1339, 2002.08
    Mohammad W. Bhuiya; Hideaki Tsuge; Haruhiko Sakuraba; Kazunari Yoneda; Nobuhiko Katunuma; Toshihisa Ohshima

  • Stabilization of Flavobacterium meningosepticum glycerol kinase by introduction of a hydrogen bond.
    Bioscience, Biotechnology, and Biochemistry
    ., 66, 1374-1377, 2002.06
    Shin-ichi Sakasegawa; Hideki Takehara; Issei Yoshioka; Hideo Misaki; Haruhiko Sakuraba; Toshihisa Ohshima

  • Novel energy metabolism in anaerobic hyperthermophilic archaea: the modified Embden-Meyerhof pathway.
    Journal of Bioscience and Bioengineering
    ., 93, 441-448, 2002.05
    Haruhiko Sakuraba; Toshihisa Ohshima

  • Dye-linked D-proline dehydrogenase from hyperthermophilic archaeon Pyrobaculum islandicum is a novel FAD-dependent amino acid dehydrogenase.
    Journal of Biological Chemistry
    ., 277, 12861-12867, 2002.04
    Takenori Satomura; Ryushi Kawakami; Haruhiko Sakuraba; Toshihisa Ohshima

  • ADP-dependent glucokinase/phosphofructokinase, a novel bifunctional enzyme from the hyperthermophilic archaeon Methanococcus jannaschii.
    Journal of Biological Chemistry
    ., 66, 873-876, 2002.04
    Haruhiko Sakuraba; Issei Yoshioka; Sinji Koga; Mamoru Takahashi; Yuki Kitahama; Takenori Satomura; Ryushi Kawakami; Toshihisa Ohshima

  • Temperature dependence of kinetic parameters for hyperthermophilic glutamate dehydrogenase from Aeropyrum pernix K1.
    Bioscience, Biotechnology,and Biochemistry
    ., 277, 12495-12498, 2002.04
    Mohammad W. Bhuiya; Haruhiko Sakuraba; Toshihisa Ohshima



 2001
  • ゲノム情報からみえた超好熱菌のNAD生合成系 -酵素の構造や機能、そして進化についての新たな情報に期待-.
    化学と生物., 39, 774-776 2001.12
    櫻庭春彦; 大島敏久

  • Increasing the themostability of Flavobacterium meningosepticum glycerol kinase by changing Ser329 to Asp in the subunit interface region.
    Protein Engineering
    ., 268, 4740-4747, 2001.09
    Shin-ichi Sakasegawa; Hideki Takehara; Issei Yoshioka; Mamoru Takahashi; Yoshitaka Kagimoto; Hideo Misaki; Haruhiko Sakuraba; Toshihisa Ohshima

  • A novel hyperthermophilic archaeal glyoxylate reductase from Thermococcus litoralis: characterization, gene cloning, nucleotide sequence and expression in Escherichia coli.
    European Journal of Biochemistry
    ., 14, 663-667, 2001.09
    Toshihisa Ohshima; Naoki-Kominato Nunoura; Tomomi Kudome; SAKURABA Haruhiko

  • Transcriptional regulation of phosphoenolpyruvate synthase by maltose in the hyperthermophilic archaeon, Pyrococcus furiosus.
    Journal of Bioscience and Bioengineering
    ., 92, 108-113, 2001.08
    Haruhiko Sakuraba; Emi Utsumi; Harold J. Schreier; Toshihisa Ohshima

  • 超好熱菌―その特異的なエネルギー代謝と酵素.
    バイオサイエンスとバイオインダストリー., 59, 439-444, 2001.07
    櫻庭春彦; 大島敏久

  • Purification, characterization, and application of a novel dye-linked L-proline dehydrogenase from a hyperthermophilic archaeon, Thermococcus profundus.
    Applied and Environmental Microbiology
    ., 67, 1470-1475, 2001.04
    Haruhiko Sakuraba; Yoshinori Takamatsu; Takenori Satomura; Ryushi Kawakami; Toshihisa Ohshima



 2000
  • Glutamate dehydrogenase from the aerobic hyperthermophilic archaeon Aeropyrum pernix K1: enzymatic characterization, identification of the encoding gene and phylogenetic implications.
    Extremophiles
    ., 4, 333, 2000.12
    Mohammad W. Bhuiya; Haruhiko Sakuraba; Chizu Kujo; Naoki-Kominato Nunoura; Yutaka Kawarabayashi; Hisasi Kikuchi; Toshihisa Ohshima

  • Biochemical characterization, cloning and sequencing of ADP-dependent (AMP-forming) glucokinase from two hyperthermophilic archaea, Pyrococcus furiosus and Thermococcus litoralis.
    Journal of Biochemistry
    ., 128, 1079-1085, 2000.12
    Shinji Koga; Issei Yoshioka; Haruhiko Sakuraba; Mamoru Takahashi; Shinichi Sakasegawa; Sakayu Shimizu; Toshihisa Ohshima

  • 高効率蛋白質発現システムの開発
    (超好熱菌のタンパク質折り畳み機構を利用した高効率蛋白質発現システムの開発).
    平成11年度知的基盤創造・利用技術研究開発事業報告書., 2000.03
    大島 敏久; 櫻庭春彦

  • 嫌気性超好熱菌の簡便な培養法.
    生化学., 72, 203-206, 2000.03
    公庄千寿; 櫻庭春彦; 大島敏久



 1999
  • 新規超好熱菌用培養装置の開発と超好熱菌の分離.
    三島海雲記念財団研究報告集., 36, 11-14, 1999.12
    大島 敏久; 櫻庭春彦

  • The NAD-dependent glutamate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum: cloning sequencing, and expression of the enzyme gene.
    Biochimica et Biophysica Acta
    ., 1434, 365-371, 1999.10
    Chizu Kujo; Haruhiko Sakuraba; Naoki Nunoura; Toshihisa Ohshima

  • An AMP-dependent (ATP-forming) kinase in the hyperthermophilic archaeon Pyrococcus furiosus: characterization and novel physiological role.
    Archives of Biochemistry and Biophysics
    ., 364, 125-128, 1999.04
    Haruhiko Sakuraba; Emi Utsumi; Chizu Kujo; Toshihisa Ohshima

  • 超好熱古細菌 Pyrococcus furiosus に存在する特異的なATP再生酵素.
    ビタミン., 73, 206-208, 1999.03
    櫻庭春彦; 大島敏久



 1996以前
  • Metabolism of glyoxylate, the end product of purin degradation in liver peroxisomes of fresh water fish.
    Biochemical and Biophysical Research Communications
    ., 229, 603-606, 1996.12
    Haruhiko Sakuraba; Satoko Fujiwara; Tomoo Noguchi

  • Alcohol: NAD+ oxidoreductase is present in rat liver peroxisomes.
    Journal of Biological Chemistry
    ., 270, 37-40, 1995.01
    Haruhiko Sakuraba; Tomoo Noguchi

  • 尿酸分解酵素群の動物進化に伴う変化-細胞内局在様式と分子構造に大きな差異.
    化学と生物., 1994.07
    野口知雄; 藤原智子; 林寿恵子; 櫻庭春彦

  • Identification of chicken liver mitochondrial alanine: 2-oxoglutarate aminotransferase and its response to starvation.
    Archives of Biochemistry and Biophysics
    ., 32, 420-422, 1994.05
    Satoko Fujiwara; Haruhiko Sakuraba; Tomoo Noguchi

  • The permeation of pyridoxal 5’-phosphate in chicken liver peroxisomes.
    Archives of Biochemistry and Biophysics
    ., 310,497-503, 1994.03
    Haruhiko Sakuraba; Tomoo Noguchi

  • Is the guinea-pig (Cavia Porcellus) a rodent?
    Comp. Biochem. Physiol.
    ., 107B, 179-182, 1994.02
    T. Noguchi; S. Fujiwara; S. Hayashi; Haruhiko Sakuraba

  • Subcellular localization and some properties of NADP+-linked malic enzymes in Euglena gracilis.
    Bioscience, Biotechnology, and Biochemistry.
    ., 57, 488-489, 1993.03
    Kazutaka Miyatake; Haruhiko Sakuraba; Hiroshi Inui; Shozaburo Kitaoka; Yoshihisa Nakano

  • ペルオキシソームのアラニン:グリオキシル酸アミノトランスフェラーゼ.
    生体の化学., 42, 189-193, 1991.06
    野口知雄; 藤原智子; 林寿恵子; 櫻庭春彦

  • Purification and characterization of peroxisomal apo and holo alanine:glyoxylate aminotransferase from bird liver.
    Archives of Biochemistry and Biophysics., 286, 453-460, 1991.05
    Haruhiko Sakuraba; Satoko Fujiwara; Tomoo Noguchi

  • Response of hepatic alanine: glyoxylate aminotransferase 1 to hormone differs among mammalian.
    Biochemical and Biophysical Research Communications., 1989.11
    Sueko Hayashi; Haruhiko Sakuraba; Tomoo Noguchi

  • Intraperoxisomal form of alanine: glyoxylate aminotransferase in the peroxisomes of bird kidney.
    Biochemical and Biophysical Research Communications., 176, 1450-1453, 1991.05
    Haruhiko Sakuraba; Satoko Fujiwara; Tomoo Noguchi

  • Birds are classified into two groups on the basis of intraperoxisomal form of hepatic alanine:glyoxylate aminotransferase.
    Enzymes Dependent on Pyridoxal Phosphate and Other Carbonyl Compound as Cofactors., 233-235, 1990.10
    Haruhiko Sakuraba; S. Fujiwara; T. Noguchi

  • ペルオキシソームの機能・生合成・病態-プリン,アミノ酸,グリオキシル酸-.
    蛋白質 核酸 酵素., 35, 1418-1426, 1990.01
    野口知雄; 藤原智子; 林寿恵子; 櫻庭春彦

  • Response of hepatic alanine: glyoxylate aminotransferase 1 to hormone differs among mammalian.
    Biochemical and Biophysical Research Communications., 165, 372-376, 1989.11
    Sueko Hayashi; Haruhiko Sakuraba; Tomoo Noguchi

  • Alanine:glyoxylate aminotransferase is present as the apoenzyme in the peroxisomes of chicken kidney.
    Biochemical and Biophysical Research Communications., 161, 696-699, 1989.06
    Haruhiko Sakuraba; Satoko Fujiwara; Tomoo Noguchi

  • Separation and determination of adenine nucleotides by high-performance liquid chromatography.
    Agricultural and Biological Chemistry., 51, 253-255, 1987.01
    Kazutaka Miyatake; Haruhiko Sakuraba; Shozaburo Kitaokai

  • Fructose-2, 6-bisphosphate activates pyruvate kinase from the protist Euglena gracilis.
    Agricultural and Biological Chemistry., 50, 2647-2649, 1986.10
    Kazutaka Miyatake; Haruhiko Sakuraba; Shozaburo Kitaoka

  • Purification and characterization of malate dehydrogenase from the phototrophic bacterium, Rhodopseudomonas capsulata.
    Biochimica et Biophysica Acta., 869, 171-177, 1986.02
    Toshihisa Ohshima; Haruhiko Sakuraba