{"id":130,"date":"2026-10-17T08:49:15","date_gmt":"2026-10-16T23:49:15","guid":{"rendered":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi_wp_test\/?page_id=130"},"modified":"2026-10-20T17:25:42","modified_gmt":"2026-10-20T08:25:42","slug":"eisosome","status":"publish","type":"page","link":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/eisosome\/","title":{"rendered":"\u9175\u6bcd\u306e\u7d30\u80de\u819c\u30de\u30a4\u30af\u30ed\u30c9\u30e1\u30a4\u30f3\u300cEisosome\u300d\u306e\u6a5f\u80fd\u3092\u89e3\u660e\u3059\u308b"},"content":{"rendered":"\n

1. \u7d30\u80de\u819c\u306b\u306f\u7279\u6b8a\u306a\u69cb\u9020\u300cEisosome\u300d\u304c\u5b58\u5728\u3059\u308b<\/h2>\n\n\n\n

\u3000\u3059\u3079\u3066\u306e\u751f\u7269\u306e\u7d30\u80de\u306f\u3001\u7d30\u80de\u819c\u306b\u3088\u3063\u3066\u5916\u754c\u3068\u9694\u3066\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u819c\u306f\u3001\u7d30\u80de\u5185\u5916\u306e\u7269\u8cea\u306e\u8f38\u9001\u3084\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u3092\u611f\u77e5\u3059\u308b\u306a\u3069\u3001\u751f\u547d\u6d3b\u52d5\u306b\u6b20\u304b\u305b\u306a\u3044\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3000\u3000
\u3000\u51fa\u82bd\u9175\u6bcd\u306e\u7d30\u80de\u819c\u306b\u306f\u3001MCC\uff08Membrane Compartment occupied by Can1\uff09<\/strong> \u3068\u547c\u3070\u308c\u308b\u7279\u6b8a\u306a\u819c\u9818\u57df\uff08\u30de\u30a4\u30af\u30ed\u30c9\u30e1\u30a4\u30f3<\/strong>\uff09\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u3053\u306e\u9818\u57df\u3067\u306f\u3001\u7d30\u80de\u819c\u304c\u5185\u5074\u306b\u7d30\u9577\u304f\u304f\u307c\u3093\u3067\u304a\u308a\u3001\u305d\u306e\u5185\u5074\u306b\u306f Eisosome\uff08\u30a8\u30a4\u30bd\u30bd\u30fc\u30e0\uff09<\/strong> \u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u304c\u5f62\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u3000Eisosome\u306f\u3001\u7d30\u80de\u819c\u306e\u69cb\u9020\u3092\u7dad\u6301\u3057\u3001\u5916\u90e8\u304b\u3089\u306e\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u5fdc\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>
\n

\u56f31\uff0eEisosome\u306e\u7d30\u80de\u5185\u5c40\u5728\u3068\u5fae\u7d30\u69cb\u9020<\/strong>
\u5de6\uff1a\u86cd\u5149\u9855\u5fae\u93e1\u306b\u3088\u308b\u89b3\u5bdf\u3067\u306f\u3001Eisosome\u306e\u4e3b\u8981\u69cb\u6210\u30bf\u30f3\u30d1\u30af\u8ceaPil1\u304c\u3001\u7d30\u80de\u819c\u306b\u6cbf\u3063\u3066\u70b9\u72b6\u307e\u305f\u306f\u7dda\u72b6\u306b\u5206\u5e03\u3059\u308b\u69d8\u5b50\u304c\u78ba\u8a8d\u3067\u304d\u307e\u3059\u3002
\u53f3\uff1a\u6025\u901f\u51cd\u7d50\u30ec\u30d7\u30ea\u30ab\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5\u306b\u3088\u3063\u3066\u89b3\u5bdf\u3057\u305f\u9175\u6bcd\u306e\u7d30\u80de\u819c\u3067\u3059\u3002\u77e2\u5370\u3067\u793a\u3057\u305f\u7d30\u9577\u3044\u6e9d\u72b6\u306e\u69cb\u9020\u304cMCC\/Eisosome\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002\u3053\u306e\u69cb\u9020\u306f\u9577\u3055\u7d04200\u301c300 nm\u3001\u6df1\u3055\u7d0450 nm\u3068\u3044\u3046\u975e\u5e38\u306b\u5c0f\u3055\u306a\u3082\u306e\u3067\u3059\u3002
\u5927\u962a\u516c\u7acb\u5927\u5b66\u30fb\u5bae\u7530\u5148\u751f\u3001\u7530\u539f\u5148\u751f\uff08\u73fe\u30fbNANIWA-EM<\/a>\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308b<\/p>\n<\/div><\/div>\n\n\n\n

<\/p>\n\n\n\n

2. Eisosome\u306f\u3069\u306e\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u3067\u304d\u3066\u3044\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n

\u3000Eisosome\u306b\u306f20\u7a2e\u985e\u4ee5\u4e0a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5c40\u5728\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u591a\u304f\u306e\u50cd\u304d\u306f\u307e\u3060\u5341\u5206\u306b\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002
\u3000\u305d\u306e\u4e2d\u3067\u3082\u3001Pil1\u3068Lsp1\u306fEisosome\u306e\u57fa\u672c\u69cb\u9020\u3092\u5f62\u6210\u3059\u308b\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea<\/strong>\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u7d30\u80de\u819c\u306e\u5185\u5074\u306b\u7d50\u5408\u3057\u3001\u819c\u304c\u304f\u307c\u3093\u3060\u69cb\u9020\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\u3000\u4e00\u65b9\u3001Sur7\u30d5\u30a1\u30df\u30ea\u30fc\u3084Nce102\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3082Eisosome\u306b\u5c40\u5728\u3057\u3001\u305d\u306e\u5f62\u6210\u3084\u6a5f\u80fd\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>
\n

\u56f32\uff0eEisosome\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u305d\u306e\u5f79\u5272<\/strong>
\u6b63\u5e38\u306a\u9175\u6bcd\uff08Wild-type\uff09\u3067\u306f\u3001Pil1\u3001Lsp1\u3001Sur7\u30d5\u30a1\u30df\u30ea\u30fc\u3001Nce102\u30d5\u30a1\u30df\u30ea\u30fc\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5354\u8abf\u3057\u3066\u3001\u7d30\u80de\u819c\u306e\u6e9d\u72b6\u69cb\u9020\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002
\u4e00\u65b9\u3001Pil1\u3092\u6b20\u640d\u3055\u305b\u305f\u9175\u6bcd\uff08pil1<\/em>\u0394\uff09\u3067\u306f\u3001Eisosome\u306e\u6b63\u5e38\u306a\u69cb\u9020\u304c\u5931\u308f\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u3001Lsp1\u306a\u3069\u306e\u4e00\u90e8\u306e\u69cb\u6210\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7d30\u80de\u819c\u4e0a\u306b\u6b8b\u5b58\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002
\u4e0b\u6bb5\u306e\u86cd\u5149\u9855\u5fae\u93e1\u5199\u771f\u306f\u3001\u6b63\u5e38\u306a\u9175\u6bcd\u3068Pil1\u6b20\u640d\u682a\u306b\u304a\u3051\u308bEisosome\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c40\u5728\u306e\u9055\u3044\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n

<\/p>\n\n\n\n

3. Eisosome\u306e\u69cb\u9020\u306f\u7d30\u80de\u819c\u3092\u5b88\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308b<\/h2>\n\n\n\n

\u3000\u79c1\u305f\u3061\u306f\u3001Eisosome\u306e\u5f62\u6210\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u50cd\u304d\u3092\u8a73\u3057\u304f\u8abf\u3079\u308b\u305f\u3081\u3001Pil1\u30846\u7a2e\u985e\u306e\u819c\u30bf\u30f3\u30d1\u30af\u8cea\uff086-Tsp\uff09\u3092\u6b20\u640d\u3055\u305b\u305f\u9175\u6bcd\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002
\u3000\u305d\u306e\u7d50\u679c\u3001Pil1\u30686\u7a2e\u985e\u306e\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u540c\u6642\u306b\u6b20\u640d\u3055\u305b\u308b\u3068\u3001\u7d30\u80de\u819c\u306e\u6b63\u5e38\u306a\u6e9d\u72b6\u69cb\u9020\u304c\u5931\u308f\u308c\u3001\u3055\u3089\u306b\u7d30\u80de\u819c\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u308b\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u8457\u3057\u304f\u5f31\u304f\u306a\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002
\u3053\u306e\u3053\u3068\u304b\u3089\u3001Eisosome\u306b\u5b58\u5728\u3059\u308b\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5354\u8abf\u3057\u3066\u3001\u7d30\u80de\u819c\u306e\u69cb\u9020\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u7dad\u6301\u3057\u3066\u3044\u308b<\/strong>\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\"\"<\/figure>
\n

\u56f33\uff0eEisosome\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6b20\u640d\u306b\u3088\u308b\u819c\u69cb\u9020\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u5909\u5316<\/strong><\/p>\n\n\n\n

\u4e0a\u6bb5\uff1a\u96fb\u5b50\u9855\u5fae\u93e1\u306b\u3088\u308b\u7d30\u80de\u819c\u306e\u89b3\u5bdf\u7d50\u679c\u3067\u3059\u3002\u6b63\u5e38\u306a\u9175\u6bcd\u3067\u306f\u6e9d\u72b6\u306e\u69cb\u9020\u304c\u898b\u3089\u308c\u307e\u3059\u304c\u3001Pil1\u30846-Tsp\u3092\u6b20\u640d\u3055\u305b\u308b\u3068\u3001\u305d\u306e\u69cb\u9020\u304c\u5909\u5316\u30fb\u6d88\u5931\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u4e0b\u6bb5\uff1a\u6b63\u5e38\u306a\u9175\u6bcd\u3068\u5404\u7a2e\u907a\u4f1d\u5b50\u6b20\u640d\u682a\u306e\u751f\u80b2\u3092\u6bd4\u8f03\u3057\u305f\u5b9f\u9a13\u3067\u3059\u3002\u7d30\u80de\u819c\u306b\u30b9\u30c8\u30ec\u30b9\u3092\u4e0e\u3048\u308bSDS\u3084\u9ad8\u6fc3\u5ea6\u306e\u5869\uff08NaCl\uff09\u3092\u542b\u3080\u57f9\u5730\u3067\u306f\u3001Pil1\u30686-Tsp\u3092\u540c\u6642\u306b\u6b20\u640d\u3057\u305f\u9175\u6bcd\u306e\u751f\u80b2\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u7d50\u679c\u306f\u3001Eisosome\u304c\u7d30\u80de\u819c\u3092\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u5b88\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n

<\/p>\n\n\n\n

4. \u7d30\u80de\u819c\u306e\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u306fTORC2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u95a2\u308f\u308b<\/h2>\n\n\n\n

\u3000\u7d30\u80de\u306f\u3001\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u3084\u7d30\u80de\u819c\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u611f\u77e5\u3059\u308b\u3068\u3001\u305d\u308c\u306b\u5bfe\u5fdc\u3059\u308b\u305f\u3081\u306e\u3055\u307e\u3056\u307e\u306a\u4ed5\u7d44\u307f\u3092\u50cd\u304b\u305b\u307e\u3059\u3002\u305d\u306e\u4e00\u3064\u304c\u3001TORC2\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306b\u3088\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/strong>\u3067\u3059\u3002
\u3000TORC2\u306f\u3001\u7d30\u80de\u819c\u306e\u72b6\u614b\u306b\u5fdc\u3058\u3066Ypk1\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3057\u3001\u7d30\u80de\u819c\u3092\u69cb\u6210\u3059\u308b\u30b9\u30d5\u30a3\u30f3\u30b4\u8102\u8cea\u306e\u5408\u6210\u306a\u3069\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001Eisosome\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6b20\u640d\u3055\u305b\u305f\u9175\u6bcd\u304b\u3089\u3001\u7d30\u80de\u819c\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u611f\u53d7\u6027\u3092\u6291\u5236\u3059\u308b\u5909\u7570\u682a\u3092\u5206\u96e2\u3057\u3001\u305d\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002
\u3000\u305d\u306e\u7d50\u679c\u3001TORC2\u306e\u69cb\u6210\u56e0\u5b50\u3067\u3042\u308bTor2\u306b\u751f\u3058\u305f\u5909\u7570\u304c\u3001\u7d30\u80de\u819c\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\"\"<\/figure>
\n

\u56f34\uff0e\u7d30\u80de\u819c\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u308f\u308bTor2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5909\u7570<\/strong><\/p>\n\n\n\n

\u4e0a\u6bb5\uff1aEisosome\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6b20\u640d\u3057\u305f\u9175\u6bcd\u306fSDS\u306b\u5bfe\u3057\u3066\u9ad8\u3044\u611f\u53d7\u6027\u3092\u793a\u3057\u307e\u3059\u304c\u3001\u305d\u3053\u304b\u3089\u5206\u96e2\u3057\u305f\u5909\u7570\u682a\u3067\u306f\u3001SDS\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u56de\u5fa9\u3057\u3066\u3044\u307e\u3059\u3002
\u4e0b\u6bb5\uff1a\u5909\u7570\u682a\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001Tor2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7570\u306a\u308b\u9818\u57df\u306b\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001Eisosome\u306e\u6a5f\u80fd\u3068TORC2\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u9593\u306b\u5bc6\u63a5\u306a\u95a2\u4fc2\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n

<\/p>\n\n\n\n

5. Eisosome\u306f\u7d30\u80de\u819c\u306e\u69cb\u9020\u7dad\u6301\u3068\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u3064\u306a\u3050<\/h2>\n\n\n\n

\u3000\u79c1\u305f\u3061\u306e\u7814\u7a76\u304b\u3089\u3001Eisosome\u306f\u5358\u306b\u7d30\u80de\u819c\u306b\u304f\u307c\u307f\u3092\u5f62\u6210\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u819c\u306e\u5b89\u5b9a\u6027\u3084\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u69cb\u9020\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002
\u3000Eisosome\u3092\u69cb\u6210\u3059\u308bPil1\u3001Lsp1\u3001Sur7\u30d5\u30a1\u30df\u30ea\u30fc\u3001Nce102\u30d5\u30a1\u30df\u30ea\u30fc\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u4e92\u3044\u306b\u5354\u8abf\u3057\u306a\u304c\u3089\u7d30\u80de\u819c\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002
\u3000\u307e\u305f\u3001\u7d30\u80de\u819c\u306b\u30b9\u30c8\u30ec\u30b9\u304c\u52a0\u308f\u308b\u3068\u3001TORC2\u2013Ypk1\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u8102\u8cea\u306e\u5408\u6210\u8abf\u7bc0\u3092\u901a\u3058\u3066\u7d30\u80de\u819c\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>
\n

\u56f35\uff0eEisosome\u306b\u3088\u308b\u7d30\u80de\u819c\u306e\u69cb\u9020\u7dad\u6301\u3068\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u30e2\u30c7\u30eb<\/strong><\/p>\n\n\n\n

Eisosome\u306f\u7d30\u80de\u819c\u306b\u5f62\u6210\u3055\u308c\u308b\u7279\u6b8a\u306a\u69cb\u9020\u3067\u3042\u308a\u3001\u8907\u6570\u306e\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3068Pil1\u306a\u3069\u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u3053\u306e\u69cb\u9020\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3059\u308b\u3053\u3068\u306f\u3001\u7d30\u80de\u819c\u306e\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3059\u3002\u307e\u305f\u3001TORC2\u2013Ypk1\u7d4c\u8def\u306f\u3001\u30b9\u30d5\u30a3\u30f3\u30b4\u8102\u8cea\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u819c\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002
\u79c1\u305f\u3061\u306f\u3001Eisosome\u306e\u69cb\u9020\u3068TORC2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6a5f\u80fd\u7684\u306a\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div><\/div>\n\n\n\n

<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u306e\u610f\u7fa9\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/h3>\n\n\n\n

\u3000\u7d30\u80de\u819c\u306e\u69cb\u9020\u3084\u8102\u8cea\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6b63\u5e38\u306b\u4fdd\u3064\u4ed5\u7d44\u307f\u306f\u3001\u9175\u6bcd\u3060\u3051\u3067\u306a\u304f\u3001\u30d2\u30c8\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u771f\u6838\u751f\u7269\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3059\u3002Eisosome\u305d\u306e\u3082\u306e\u306f\u4e3b\u306b\u83cc\u985e\u3067\u898b\u3089\u308c\u308b\u69cb\u9020\u3067\u3059\u304c\u3001\u52d5\u7269\u7d30\u80de\u306b\u306f\u3001\u7d30\u80de\u819c\u306e\u304f\u307c\u307f\u3092\u5f62\u6210\u3059\u308bCaveolae\uff08\u30ab\u30d9\u30aa\u30e9\uff09\u3068\u547c\u3070\u308c\u308b\u69cb\u9020\u304c\u3042\u308a\u307e\u3059\u3002\u4e21\u8005\u306f\u7570\u306a\u308b\u69cb\u6210\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6301\u3064\u3082\u306e\u306e\u3001\u7d30\u80de\u819c\u306e\u5b89\u5b9a\u6027\u3084\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u95a2\u308f\u308b\u3068\u3044\u3046\u6a5f\u80fd\u7684\u306a\u5171\u901a\u70b9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u9175\u6bcd\u306eEisosome\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u306f\u3001\u7d30\u80de\u819c\u304c\u3069\u306e\u3088\u3046\u306b\u5f62\u6210\u3055\u308c\u3001\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u304b\u3089\u5b88\u3089\u308c\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3046\u751f\u547d\u306e\u57fa\u672c\u539f\u7406\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n
    \n
  1. Mal\u00ednsk\u00e1, K., Mal\u00ednsk\u00fd, J., Opekarov\u00e1, M., and Tanner, W. Visualization of protein compartmentation within the plasma membrane of living yeast cells. Molecular Biology of the Cell, 14(11), 4427\u20134436 (2003).
    DOI: 10.1091\/mbc.E03-04-0221<\/a><\/li>\n\n\n\n
  2. Malinska, K., Malinsky, J., Opekarova, M., and Tanner, W. Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells. Journal of Cell Science, 117(25), 6031\u20136041 (2004).
    DOI:     10.1242\/jcs.01493<\/a><\/li>\n\n\n\n
  3. Walther, T. C., Brickner, J. H., Aguilar, P. S., Bernales, S., Pantoja, C., and Walter, P. Eisosomes mark static sites of endocytosis. Nature, 439(7079), 998\u20131003 (2006).
    DOI:     10.1038\/nature04472<\/a><\/li>\n\n\n\n
  4. Sakata, K.-t., Hashii, K., Yoshizawa, K., Tahara, Y. O., Yae, K., Tsuda, R., Tanaka, N., Maeda, T., Miyata, M., and Tabuchi, M. Coordinated regulation of TORC2 signaling by MCC\/eisosome-associated proteins, Pil1 and tetraspan membrane proteins during the stress response. Molecular Microbiology, 117(5), 1227\u20131244 (2022).
    DOI:     10.1111\/mmi.14903<\/a><\/li>\n<\/ol>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    1. \u7d30\u80de\u819c\u306b\u306f\u7279\u6b8a\u306a\u69cb\u9020\u300cEisosome\u300d\u304c\u5b58\u5728\u3059\u308b \u3000\u3059\u3079\u3066\u306e\u751f\u7269\u306e\u7d30\u80de\u306f\u3001\u7d30\u80de\u819c\u306b\u3088\u3063\u3066\u5916\u754c\u3068\u9694\u3066\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u819c\u306f\u3001\u7d30\u80de\u5185\u5916\u306e\u7269\u8cea\u306e\u8f38\u9001\u3084\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u3092\u611f\u77e5\u3059\u308b\u306a\u3069\u3001\u751f\u547d\u6d3b\u52d5\u306b\u6b20\u304b\u305b\u306a\u3044\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lightning_design_setting":{"layout":"col-one-no-subsection"},"footnotes":""},"class_list":["post-130","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/pages\/130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/comments?post=130"}],"version-history":[{"count":25,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/pages\/130\/revisions"}],"predecessor-version":[{"id":266,"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/pages\/130\/revisions\/266"}],"wp:attachment":[{"href":"https:\/\/www.ag.kagawa-u.ac.jp\/tabuchi\/wp-json\/wp\/v2\/media?parent=130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}