活性構造化学研究室
Laboratory of Natural Products Chemistry, Kagawa University
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原著論文 (Original articles)
[
bold
: Lab member]
Hara Y.
*; Nakamura A.; Manome T.; Takaya A.; Takahashi H.; Ban S.; Yaguchi T.; Ishibashi M.
A new diterpenoid, carneadiol, isolated from
Nocardia carnea
IFM 12324
J. Nat. Med.
79, 435-440 (2025).
Hanaki Y.;
Hara Y.
;
Mori M.
; Tomiyoshi K.
Identification of lotus cultivar-specific rhizome compounds and evaluation of their growth inhibitory activity against
Fusarium commune
Fundam. Toxicol. Sci.
12(1), 1-5 (2025).
Hanaki Y.; Abe R.; Sugiyama, Y.;
Hara, Y.
; Yanagita, R. C.
A new labdane-type diterpenoid from leaves of
Vitex rotundifolia
Results Chem.
7, 101512 (2024).
Yamaguchi J.; Manome T.;
Hara Y.
; Yamazaki Y.; Nakamura Y.; Ishibashi M.; Takaya A.
Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of
Staphylococcus aureus
by binding to AgrA
Front. Pharmacol.
15, 1365815 (2024).
Fujii K.; Iwata I.; Takaya A.; Ishibashi M.;
Hara Y.
*
New biflavonoids isolated from
Xylia kerrii
leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells
J. Nat. Med.
78(3), 732-740 (2024).(
https://rdcu.be/dEhFu
)
Rakhi, S. A.;
Hara, Y.
; Islam, M. S.; Manome, T.; Alam, S.; Emon, N. U.; Al-Mansur, M. A., Kuddus, M. R.; Sarkar, M. R.; Ishibashi, M.; Ahmed F.
Isolation of bioactive phytochemicals from
Crinum asiaticum
L. along with their cytotoxic and TRAIL-resistance abrogating prospect assessment
Heliyon
, 10(3), e25049 (2023).
Ito, T.;
Hara, Y
.; Fukaya, M.; Ryu, K.; Iinuma M.
Resveratrol tetramer vaticanol N with a tribenzobicyclo[3.3.2]decatriene skeleton isolated from the leaves of
Vatica bantamensis
Phytochem. Lett.
57, 16-21 (2023).
Hara, Y.
*; Manome, T.; Suehiro, W.; Harada, S.; Yamagishi, Y.; Takaya, A.; Ogra, Y.; Ishibashi, M.
Isolation of two new trichorzin PA derivatives, trichorzin PA X and XI, from the terrestrial fungus
Trichoderma harzianum
IFM 66736
Tetrahedron Lett.
121, 15488 (2023).
Manome, T.;
Hara, Y.
*; Ishibashi, M.
Isolation of various flavonoids with TRAIL resistance-overcoming activity from
Blumea lacera
Molecules
28(1), 264-264 (2023).
Manome, T.;
Hara, Y.
*; Ishibashi, M.
A new 1,2-diketone physalin isolated from
Physalis minima
and TRAIL-resistance overcoming activity of physalins
J. Nat. Med.
77 (2), 370-378 (2023).
Fujii, K.;
Hara, Y.
*; Arai, M.A.; Sadhu, S.K.; Ahmed, F.; Ishibashi, M.
Natural compounds with BMI1 promoter inhibitory activity from
Mammea siamensis
and
Andrographis paniculata
Chem. Pharm. Bull.
70 (12), 885-891 (2022).
Jitrangsri, K.;
Hara, Y.
*; Takaya, A.; Ishibashi, M.
New polyoxygenated cyclohexenes isolated from
Uvaria rufa
and cinnamtannin B1 isolated from
Nephelium hypoleucum
with TRAIL-resistance-overcoming activity
Phytochem. Lett.
52, 7-9 (2022).
Hara, Y.
*; Watanabe, K.; Takaya, A.; Ebihara, I.; Manome, T.; Arai, M.A.; Yaguchi, T.; Ishibashi, M.
Two bioactive compounds, uniformides A and B, isolated from a culture of
Nocardia uniformis
IFM0856
T
in the presence of animal cells
Org. Lett.
24 (27), 4998-5002 (2022); Correction: 24 (31), 5867 (2022).
Manome, T.;
Hara, Y.
*; Ahmed, F.; Sadhu, S.K.; Ishibashi, M.
Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from
Terminalia bellirica
J. Nat. Med.
76 (2), 482-489 (2022).
Hara, Y.
*; Chiba, M.; Watanabe, K.; Ishibashi, M.
Isolation of ikahonone, 4-methyl-2,4-dihydroxy-3-pentanone from
Bacillus cereus
IFM12235
Heterocycles
105 (1), 523-531 (2022).
Hara, Y.
*; Tanimura, D.; Manome, T.; Arai, M.A.; Yaguchi, T.; Ishibashi, M.
Isolation of peptidolipin NA derivatives from the culture of
Nocardia arthiritidis
IFM10035
T
in the presence of mouse macrophage cells
Heterocycles
104 (1), 185-190 (2022).
Jitrangsri, K.; Takaya, A.;
Hara, Y.
; Sadhu, S.K.; Ahmed, F.; Ishibashi, M.
Bioactivity-guided isolation of TRAIL-resistance overcoming activity compounds from the leaves of
Murraya exotica
Nat. Prod. Commun
. 16 (12), 1934578X211065843 (2021).
Arai, M.A.; Sakuraba, K.; Makita, Y.;
Hara, Y.
; Ishibashi, M.
Evaluation of naturally occurring HIF-1 inhibitors for pulmonary arterial hypertension
ChemBioChem
22, 2799-2804 (2021).
Ohizumi, Y.; Kawada, M.; Kamada, M.; Nakajima, A.; Kajima, K.; Uozumi, N.;
Hara, Y
.; Guo, Y.; Ishibashi, M.
Isolation of adenosine and cordysinin B from
Anredera cordifolia
that stimulates CRE-mediated transcription in PC12 cells
Planta Med. Int.
Open
8 (01), e19-e24 (2021).
Arai, M.A.; Ebihara, I.; Makita, Y.;
Hara, Y.
; Yaguchi, T.; Ishibashi, M.
Isolation of nocobactin NAs as Notch signal inhibitors from
Nocardia farcinica
, a possibility of invasive evolution
J. Antibiot.
74 (4), 255-259 (2021).
Hara, Y.
; Totsugi, Y.; Ichikawa, H.; Harada, S.; Fujii, K.; Ahmed, F.; Sadhu, S.K.; Arai, M.A.; Ishibashi, M.
Acacienone, a terpenoid‑like natural product having an unprecedented C20 framework isolated from
Acacia mangium
leaves
J. Nat. Med.
75 (1), 99-104 (2021).
Sakai, K.;
Hara, Y.
; Ishibashi, M.; Sakai, M.; Kawahara, S.; Imanishi, S.; Harada, K.; Hoshino, Y.; Komaki, H.; Mukai, A.; Gonoi, T.
Characterization of nocardithiocin derivatives produced by amino acid substitution of precursor peptide notG
Int. J. Pept. Res. Ther.
26, 281-290 (2020).
Sato, T.; Arai, M.A.; Yixizhuoma;
Hara, Y.
; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
Cadinane sesquiterpenoids isolated from
Santalum album
using a screening program for Wnt signal inhibitory activity
J. Nat. Med.
74 (2), 476-481 (2020).
Jomori, T.;
Hara, Y.
; Sasaoka, M.; Harada, K.; Setiawan, A.; Hirata, K.; Kimishima, A.; Arai, M.
Mycobacterium smegmatis
alters the production of secondary metabolites by marine-derived
Aspergillus niger
J. Nat. Med.
74 (1), 76-82 (2020).
Kobayashi, N.;
Hara, Y.
; Arai, M.A.; Hara, S.; Gonoi, T.; Yaguchi, T.; Ishibashi, M.
Isolation of inohanalactone, a γ-butyrolactone, from
Nocardia inohanensis
IFM0092
T
Heterocycles
101 (1), 312-317 (2020).
Yokoyama, Y.; Arai, M.A.;
Hara, Y.
; Ishibashi, M.
Nonactic acid derivatives isolated from
Streptomyces werraensis
IFM12104 in a screening program for BMI1 promoter inhibitory activity
Nat. Prod. Commun.
14 (7), 1934578X1986658. (2019).
Yokoyama, Y.; Arai, M.A.;
Hara, Y.
; Ishibashi, M.
Identification of BMI1 promoter inhibitors from
Streptomyces
sp. IFM-11958
Bioorg. Med. Chem.
, 27 (13), 2998-3003 (2019).
Hara, S.;
Hara, Y
.; Arai, M.A.; Kusuya, Y.; Takahashi, H.; Yaguchi, T.; Ishibashi, M.
Isolation of nabscessin C from
Nocardia abscessus
IFM 10029
T
and a study on biosynthetic pathway for nabscessins
Chem. Pharm. Bull.
66 (10), 976-982 (2018).
Hara, Y.
; Arai, M.A.; Toume, K.; Masu, H.; Sato, T.; Komatsu, K.; Yaguchi, T.; Ishibashi, M.
Coculture of a pathogenic actinomycete and animal cells to produce nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect
Org. Lett.
20 (18), 5831-5834 (2018).
Hara, Y.
; Arai, M.A.; Sakai, K.; Ishikawa, N.; Gonoi, T.; Yaguchi, T.; Ishibashi, M.
Dehydropropylpantothenamide isolated by a co-culture of
Nocardia tenerifensis
IFM 10554
T
in the presence of animal cells
J. Nat. Med.
72 (1), 280-289 (2018).
Hara, S.; Ishikawa, N.;
Hara, Y.
; Nehira, T.; Sakai, K.; Gonoi, T.; Ishibashi, M.
Nabscessins A and B, aminocyclitol derivatives from
Nocardia abscessus
IFM 10029
T
J. Nat. Prod.
80 (2), 565-568 (2017).
Ito, T.;
Hara, Y.
; Kubota, Y.; Sawa, R.; Iinuma, M.
Absolute structure of resveratrol hexamers in Dipterocarpaceaeous plants
Tetrahedron
72 (7), 891-899 (2016).
Ito, T.; Hoshino, R.;
Hara, Y.
; Oyama, M.; Iinuma, M.
Absolute configuration and conformational analysis of
C
-glucoside of a resveratrol trimer: Structure of hopeaside E from
Hopea utilis
Phytochem. Lett.
6 (2), 193-197 (2013).
Ito, T.;
Hara, Y.
; Oyama, M.; Tanaka, T.; Murata, J.; Darnaedi, D.; Iinuma, M.
Occurrence of bergenin phenylpropanoates in
Vatica bantamensis
Phytochem. Lett.
5 (4), 743-746 (2012).
特許
(Patent)
出願番号:特願2016-120162
名称:ナブセシンA、ナブセシンB、及びその製造方法
発明者:石橋正己・原昇子・原康雅・石川直樹・酒井香奈江・五ノ井透
出願人:千葉大学 出願日:2016.6.16
公開番号:特開2017-222617 公開日:2017.12.21
Reviews, Books, and Others
原康雅
「ゲノム解析より見いだされたペプチドはCa
2+
依存性抗生物質開拓に繋がるか？」
ファルマシア
, 61 (1), 68 (2025). (
invited
)
interviewee: 原康雅
生物が創り出す未知の天然物や有用な天然物をさがす！
香川大学農学部 「高校生のための注目の研究者・研究ミニ解説第13回」 2024年12月23日 (
農学部HP
,
Instagram
公開)
Hara, Y.*
Search for natural products from actinomycetes of the genus
Nocardia
Journal of Natural Medicines
, 78 (4), 828-837 (2024).
(invited)
原康雅
2022年度猪之鼻奨学会研究助成金研究報告「放線菌
Nocardia
の産生する感染宿主との相互作用に寄与する天然物の探索とその機能解明」
千葉医学
, 99, 156-157 (2023).
原康雅
香川大学研究シーズの紹介（第101回）「植物や微生物からの天然物探索」
一般財団法人百十四経済研究所: 調査月報No.438, 2023年9月.
原康雅
情報・政策トピックス「植物や微生物からの天然物探索」
香川ニュービジネスクラブ事務局: KNBC News No. 279, 2023年9月.
原康雅
「
B. gladioli
菌由来の天然物はシデロフォアか？」
化学
, 76 (8), 62-63 (2021).
(invited)
interviewee: 原康雅, 石橋正己
「菌の化合物 新探索法」
日経産業新聞 2018年3月28日.
原康雅
「放線菌に動物細胞を混ぜて得た新しい化合物」
日本薬学会第138年会 (金沢) 報道機関向け講演ハイライト, 2018, 30.
原康雅
「臨床分離菌から得られたマクロライドは多剤耐性結核克服への希望となるか？」
ファルマシア
, 54 (2), 165 (2018).
(invited)