Bold : Lab member,  * Corresponding author

Peer-Reviewed-Papers

13. Suzuki, Y., Moritoki, K., Kajiwara, M., Yanagita, R. C.*, Kawanami, Y., Hanaki, Y., and Irie, K.: Design, synthesis, and biological activity of synthetically accessible analog of aplysiatoxin with (R)-(–)-carvone-based conformation-controlling unit. Biosci. Biotechnol. Biochem., in press.

12. Yanagita, R. C.*, Otani, M., Hatanaka, S., Nishi, H., Miyake, S., Hanaki, Y., Sato, M., Kawanami, Y., and Irie, K.: Analysis of binding mode of vibsanin A with protein kinase C C1 domeins: An experimental and molecular dynamics simulation study. J. Mol. Struct., 1260, 132866 (2022).

Supervised Works

11.  Huffman, B. J., Chu, T., Hanaki, Y., Wong, J., Chen, S., Houk, K., and Shenvi, R. A.*: Stereodivergent Attached-Ring Synthesis via Non-Covalent Interactions: A Short Formal Synthesis of Merrilactone A. Angew. Chem. Int. Ed., 61 (3), e202114514 (2022).

10. Hanaki, Y.*, Araki, Y., Nishikawa, T., and Yanagita, R. C.: Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines. Heterocycles, 102 (12), 2353-2362 (2021)

9.  Hanaki, Y.*, Araki, Y., Nishikawa, T., and Yanagita, R. C.: Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions. Fundam. Toxicol. Sci., 8 (3), 69-73 (2021).

8.  Araki, Y.Hanaki, Y. (equal contribution), Kita, M., Hayakawa, K., Irie, K., Nokura, A., Nakazaki, A., and Nishikawa, T.*: Total synthesis and biological evaluation of oscillatoxins D, E, and F. Biosci. Biotechnol. Biochem., 85 (6), 1371-1382 (2021).

7.  Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S., and Irie, K.*: Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, a Potential Anti-Cancer Lead Derived from Debromoaplysiatoxin. Heterocycles, 97 (1), 478-492 (2018).

6.  Hanaki, Y., Shikata, Y., Kikumori, M., Hotta, N., Imoto, M., and Irie, K.*: Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem. Biophys. Res. Commun., 495 (1), 438-445 (2018).

5.  Hanaki, Y., Kikumori, M., Tokuda, H., Okamura, M., Dan, S., Adachi, N., Saito, N., Yanagita, R. C., and Irie, K.*: Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-Aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory ActivitiesMolecules, 22 (4), 631 (2017).

4.  Irie, Y., Murakami, K., Hanaki, M., Hanaki, Y., Suzuki, T., Monobe, Y., Takai, T., Akagi, K., and Irie, K.*: Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant NeurotoxicityACS Chem. Neurosci., 8 (4), 807-816 (2017).

3.  Hanaki, Y., Yanagita, R. C., Sugahara, T., Aida, M., Tokuda, H., Suzuki, N., and Irie, K.*: Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities Biosci. Biotechnol. Biochem., 79 (6), 888-895 (2015).

2.  Jiang, W., Tan, S., Hanaki, Y., Irie, K., Uchida, H., Watanabe, R., Suzuki, T., Sakamoto, B., Kamio, M., and Nagai, H.*: Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea Producens. Marine Drugs, 12 (12), 5788-5800 (2014).

1.  Hanaki, Y., Kikumori, M., Ueno, S., Tokuda, H., Suzuki, N., and Irie, K.*: Structure–activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activityTetrahedron, 69 (36), 7636-7645 (2013).