Publications

Peer-Reviewed Papers

（Bold : Lab member,  * Corresponding author）

 

Six-step synthesis and epithelial–mesenchymal transition-inhibitory activity of a tetralone-based vitetrifolin analog.

Yusuke Hanaki*, Yasunori Sugiyama, Ryo C. Yanagita.

Biosci. Biotechnol. Biochem. 2025, in press.

 

Identification of lotus cultivar-specific rhizome compounds and evaluation of thier growth inhibitory activity against Fusarium commune.

Yusuke Hanaki*, Yasumasa Hara, Miu Mori, Keita Tomiyoshi.

Fundam. Toxicol. Sci. 2025, 12 (1), 1–5.

 

Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R)-(–)-carvone-based core.

Ryo C. Yanagita*, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.

Biosci. Biotechnol. Biochem. 2024, 88 (9), 992–998.

 

A new labdane-type diterpenoid from leaves of Vitex rotundifolia.

Yusuke Hanaki*, Rintaro Abe, Yasunori Sugiyama, Yasumasa Hara, Ryo C. Yanagita.

Results Chem. 2024, 7, 101512.

 

Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation.

Jumpei Maki, Yusuke Hanaki, Ryo C. Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie*.

Biosci. Biotechnol. Biochem. 2023, 87 (12), 1453–1461.

 

In vivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest.

Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Mutsumi Okamura, Shingo Dan, Masaya Imoto, Kazuhiro Irie*.

Biochem. Biophys. Res. Commun. 2023, 675, 19–25.

 

Cell Morphology-Based Screening Identified Vitetrifolin D from Vitex Rotundifolia as an Inhibitor of Phorbol Ester-Induced Downregulation of E-Cadherin in HHUA Endometrial Cells.

Yusuke Hanaki*, Nichika Iwase, Yasunori Sugiyama, Sena Miyoshi, Ryo C. Yanagita.

BPB Reports 2023, 6 (3), 103-107.

 

A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities.

Tomoki Sekido, Kosuke Yamamoto, Ryo C. Yanagita*, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.

Bioorg. Med. Chem. 2022, 73, 116988.

 

12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial–mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases.

Yusuke Hanaki*, Sena Miyoshi, Yasunori Sugiyama, Ryo C. Yanagita, Masashi Sato.

Biosci. Biotechnol. Biochem. 2022, 86 (10), 1417-1422. [Accepted Manuscript]

 

Design, synthesis, and biological activity of synthetically accessible analog of aplysiatoxin with (R)-(–)-carvone-based conformation-controlling unit.

Yoshiyuki Suzuki, Keiichi Moritoki, Mizuki Kajiwara, Ryo C. Yanagita*, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie.

Biosci. Biotechnol. Biochem. 2022, 86 (8), 1013-1023.

 

Analysis of binding mode of vibsanin A with protein kinase C C1 domeins: An experimental and molecular dynamics simulation study.

Ryo C. Yanagita*, Mao Otani, Satoshi Hatanaka, Hiroto Nishi, Shota Miyake, Yusuke Hanaki, Masashi Sato, Yasuhiro Kawanami, Kazuhiro Irie.

J. Mol. Struct. 2022, 1260, 132866.

 

Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines.

Yusuke Hanaki*, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita.

Heterocycles 2021, 102 (12), 2353-2362.

 

Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions.

Yusuke Hanaki*, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita.

Fundam. Toxicol. Sci. 2021, 8 (3), 69-73.

 

 

Before Kagawa Univ.

 

Stereodivergent Attached-Ring Synthesis via Non-Covalent Interactions: A Short Formal Synthesis of Merrilactone A.

Benjamin J. Huffman, Tiffany Chu, Yusuke Hanaki, Jonathan Wong, Shuming Chen, Ken Houk, Ryan A. Shenvi*.

Angew. Chem. Int. Ed. 2022, 61 (3), e202114514.

 

Total synthesis and biological evaluation of oscillatoxins D, E, and F.

Yusuke Araki^†, Yusuke Hanaki^† (^†equal contribution), Masaki Kita, Koutaro Hayakawa, Kazuhiro Irie, Yoshihiko Nokura, Atsuo Nakazaki, Toshio Nishikawa*.

Biosci. Biotechnol. Biochem. 2021, 85 (6), 1371-1382.

 

Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, a Potential Anti-Cancer Lead Derived from Debromoaplysiatoxin.

Koutaro Hayakawa, Yusuke Hanaki, Harukuni Tokuda, Ryo C. Yanagita, Yu Nakagawa, Mutsumi Okamura, Shingo Dan, Kazuhiro Irie*.

Heterocycles 2018, 97 (1), 478-492.

 

Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.

Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Natsuki Hotta, Masaya Imoto, Kazuhiro Irie*.

Biochem. Biophys. Res. Commun. 2018, 495 (1), 438-445.

 

Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-Aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.

Yusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie*.

Molecules 2017, 22 (4), 631.

 

Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity.

Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-ichi Akagi, Kazuhiro Irie*.

ACS Chem. Neurosci. 2017, 8 (4), 807-816.

 

Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities.

Yusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*.

Biosci. Biotechnol. Biochem. 2015, 79 (6), 888-895.

 

Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea Producens.

Weina Jiang, Satoshi Tan, Yusuke Hanaki, Kazuhiro Irie, Hajime Uchida, Ryuichi Watanabe, Toshiyuki Suzuki, Bryan Sakamoto, Michiya Kamio, Hiroshi Nagai*.

Marine Drugs 2014, 12 (12), 5788-5800.

 

Structure–activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity.

Yusuke Hanaki, Masayuki Kikumori, Sayo Ueno, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie*.

Tetrahedron 2013, 69 (36), 7636-7645.