Simplified analogues of natural products published in 2018

Google Scholar and PubMed search results for “”simplified analogue” natural products”, “”simplified analogues” natural products”, “”simplified-analog” natural products”, “”simplified analogs” natural products”, “”function-oriented-synthesis” natural products”, and “pseudo-natural-products”

1. Giltrap AM, Haeckl FPJ, Kurita KL, Linington RG, Payne RJ. Synthetic Studies Toward the Skyllamycins: Total Synthesis and Generation of Simplified Analogues. J Org Chem. 2018 Jul 6;83(13):7250-7270. doi: 10.1021/acs.joc.8b00898. Epub 2018 Jun 11. PMID: 29798664.
2. Mills JJ, Robinson KR, Zehnder TE, Pierce JG. Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A. Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8682-8686. doi: 10.1002/anie.201805078. Epub 2018 Jun 10. PMID: 29845720; PMCID: PMC6033662.
3. Liu N, Zhong H, Tu J, Jiang Z, Jiang Y, Jiang Y, Jiang Y, Li J, Zhang W, Wang Y, Sheng C. Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors. Eur J Med Chem. 2018 Jan 1;143:1510-1523. doi: 10.1016/j.ejmech.2017.10.043. Epub 2017 Oct 16. PMID: 29126739.
4. Ohtawa M, Arima S, Ichida N, Terayama T, Ohno H, Yamazaki T, Ohshiro T, Sato N, Omura S, Tomoda H, Nagamitsu T. Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors. ChemMedChem. 2018 Mar 6;13(5):411-421. doi: 10.1002/cmdc.201700645. Epub 2018 Jan 30. PMID: 29323466.
5. Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA. Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles. ChemMedChem. 2018 Feb 20;13(4):303-311. doi: 10.1002/cmdc.201700752. Epub 2018 Jan 19. PMID: 29349898; PMCID: PMC5894512.
6. Liu J, Chen Y, Li JY, Luo C, Li J, Chen KX, Li XW, Guo YW. Function-Oriented Synthesis of Marine Phidianidine Derivatives as Potential PTP1B Inhibitors with Specific Selectivity. Mar Drugs. 2018 Mar 20;16(3):97. doi: 10.3390/md16030097. PMID: 29558377; PMCID: PMC5867641.
7. Caso A, Laurenzana I, Lamorte D, Trino S, Esposito G, Piccialli V, Costantino V. Smenamide A Analogues. Synthesis and Biological Activity on Multiple Myeloma Cells. Mar Drugs. 2018 Jun 13;16(6):206. doi: 10.3390/md16060206. PMID: 29899231; PMCID: PMC6025564.
8. Bhat C, Ilina P, Tilli I, Voráčová M, Bruun T, Barba V, Hribernik N, Lillsunde KE, Mäki-Lohiluoma E, Rüffer T, Lang H, Yli-Kauhaluoma J, Kiuru P, Tammela P. Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives. Mar Drugs. 2018 Dec 3;16(12):481. doi: 10.3390/md16120481. PMID: 30513862; PMCID: PMC6316490.
9. Thombare VJ, Holden JA, Pal S, Reynolds EC, Chattopadhyay A, O’Brien-Simpson NM, Hutton CA. Antimicrobial activity of simplified mimics of celogentin C. Tetrahedron. 2018 Mar 22;74(12):1288-1293. doi: 10.1016/j.tet.2017.12.032. 
10. Wu Y, Dockendorff C. Synthesis of a novel bicyclic scaffold inspired by the antifungal natural product sordarin. Tetrahedron Lett. 2018 Sep 5;59(36):3373-3376. doi: 10.1016/j.tetlet.2018.07.064.
11. D’Errico S, Borbone N, Catalanotti B, Secondo A, Petrozziello T, Piccialli I, Pannaccione A, Costantino V, Mayol L, Piccialli G, Oliviero G. Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs. Mar Drugs. 2018 Mar 10;16(3):89. doi: 10.3390/md16030089. PMID: 29534435; PMCID: PMC5867633.
12. Zhuo CX, Fürstner A. Catalysis-Based Total Syntheses of Pateamine A and DMDA-Pat A. J Am Chem Soc. 2018 Aug 22;140(33):10514-10523. doi: 10.1021/jacs.8b05094. Epub 2018 Aug 14. PMID: 30056701.
13. Riemer M , Uzunova VV , Riemer N , Clarkson GJ , Pereira N , Napier R , Shipman M . Phyllostictine A: total synthesis, structural verification and determination of substructure responsible for plant growth inhibition. Chem Commun (Camb). 2018 Jun 26;54(52):7211-7214. doi: 10.1039/c8cc03349h. PMID: 29897060; PMCID: PMC6018569.
14. Chen G, Wang R, Vue B, Patanapongpibul M, Zhang Q, Zheng S, Wang G, White JD, Chen QH. Optimized synthesis and antiproliferative activity of desTHPdactylolides. Bioorg Med Chem. 2018 Jul 23;26(12):3514-3520. doi: 10.1016/j.bmc.2018.05.026. Epub 2018 May 18. PMID: 29784275; PMCID: PMC6008235.
15. Hayakawa K, Hanaki Y, Tokuda H, Yanagita RC, Nakagawa Y, Okamura M, Dan S, Irie K. Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, a Potential Anti-Cancer Lead Derived from Debromoaplysiatoxin. Heterocycles 2018 Sep 18; 97(1):478 – 492. doi: 10.3987/COM-18-S(T)37. Epub 2018 Apr 5.
16. Pan X, Tao L, Ji M, Chen X, Liu Z. Synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A. Bioorg Med Chem Lett. 2018 Mar 1;28(5):866-868. doi: 10.1016/j.bmcl.2018.02.004. Epub 2018 Feb 9. PMID: 29433924.
17. Steele AD, Ernouf G, Lee YE, Wuest WM. Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action. Org Lett. 2018 Feb 16;20(4):1126-1129. doi: 10.1021/acs.orglett.8b00054. Epub 2018 Feb 1. PMID: 29388431; PMCID: PMC5869691.
18. Liu XY, Li XY, Yang FL, Li Y, Jiao XZ, Xie P. Design, synthesis of a novel 4-O-methylsaucerneol analogue LXY7824 as potent HIF-1 inhibitor and anti-cancer agent. J Asian Nat Prod Res. 2018 Jun;20(6):545-558. doi: 10.1080/10286020.2018.1473386. Epub 2018 Jun 4. PMID: 29862843.
19. Suen LM, Tekle-Smith MA, Williamson KS, Infantine JR, Reznik SK, Tanis PS, Casselman TD, Sackett DL, Leighton JL. Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1. Nat Commun. 2018 Nov 9;9(1):4710. doi: 10.1038/s41467-018-07259-x. PMID: 30413713; PMCID: PMC6226463.
20. Zhao X, Kedei N, Michalowski A, Lewin NE, Keck GE, Blumberg PM. Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency. Chembiochem. 2018 May 18;19(10):1049-1059. doi: 10.1002/cbic.201700677. Epub 2018 Apr 27. PMID: 29517836; PMCID: PMC7032040.
21. Gabet B, Kuo PC, Fuentes S, Patel Y, Adow A, Alsakka M, Avila P, Beam T, Yen JH, Brown DA. Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents. Bioorg Med Chem. 2018 Nov 15;26(21):5711-5717. doi: 10.1016/j.bmc.2018.10.020. Epub 2018 Oct 22. PMID: 30449427.
22. Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett. 2018 Mar 18;9(6):540-545. doi: 10.1021/acsmedchemlett.8b00011. PMID: 29937979; PMCID: PMC6004574.
23. Chen J, Li J, Wu L, Geng Y, Yu J, Chong C, Wang M, Gao Y, Bai C, Ding Y, Chen Y, Zhang Q. Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. Eur J Med Chem. 2018 May 10;151:601-627. doi: 10.1016/j.ejmech.2018.03.078. Epub 2018 Mar 29. PMID: 29656202.
24. Fujita S, Suyama M, Matsumoto K, Yamamoto A, Yamamoto T, Hiroshima Y, Iwata T, Kano A, Shinohara Y, Shindo M. Synthesis and evaluation of simplified functionalized bongkrekic acid analogs. Tetrahedron. 2018 Mar 1;74(9):962-969. doi: 10.1016/j.tet.2018.01.018.