Simplified analogues of natural products published in 2016

Google Scholar and PubMed search results for “”simplified analogue” natural products”, “”simplified analogues” natural products”, “”simplified-analog” natural products”, “”simplified analogs” natural products”, “”function-oriented-synthesis” natural products”, and “pseudo-natural-products”. 


  1. Hemi Cumming A, Brown SL, Tao X, Cuyamendous C, Field JJ, Miller JH, Harvey JE, Teesdale-Spittle PH. Synthesis of a simplified triazole analogue of pateamine A. Org Biomol Chem. 2016 Jun 14;14(22):5117-27. doi: 10.1039/c6ob00086j. Epub 2016 May 16. PMID: 27180995; PMCID: PMC5166979.
  2. Tsakos M, Clement LL, Schaffert ES, Olsen FN, Rupiani S, Djurhuus R, Yu W, Jacobsen KM, Villadsen NL, Poulsen TB. Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue. Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1030-5. doi: 10.1002/anie.201509926. Epub 2015 Dec 4. PMID: 26637117.
  3. Kikumori M, Yanagita RC, Tokuda H, Suenaga K, Nagai H, Irie K. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead. Biosci Biotechnol Biochem. 2016;80(2):221-31. doi: 10.1080/09168451.2015.1091718. Epub 2015 Oct 9. PMID: 26452398.
  4. Chiba T, Kitahata S, Matsuda A, Ichikawa S. Design, Synthesis and Biological Evaluation of a Structurally Simplified Syringolin A Analogues. Chem Pharm Bull (Tokyo). 2016;64(7):811-6. doi: 10.1248/cpb.c16-00182. PMID: 27373636.
  5. Zhan Y, Zhang XW, Xiong Y, Li BL, Nan FJ. Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2). Org Biomol Chem. 2016 Jan 14;14(2):747-751. doi: 10.1039/c5ob02019k. PMID: 26584338.
  6. Florence GJ, Fraser AL, Gould ER, King EF, Menzies SK, Morris JC, Thomson MI, Tulloch LB, Zacharova MK, Smith TK. Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors. ChemMedChem. 2016 Jul 19;11(14):1503-6. doi: 10.1002/cmdc.201600210. Epub 2016 Jun 10. PMID: 27283448; PMCID: PMC5111590.
  7. Huang B, Zhang F, Yu G, Song Y, Wang X, Wang M, Gong Z, Su R, Jia Y. Gram Scale Syntheses of (-)-Incarvillateine and Its Analogs. Discovery of Potent Analgesics for Neuropathic Pain. J Med Chem. 2016 Apr 28;59(8):3953-63. doi: 10.1021/acs.jmedchem.6b00132. Epub 2016 Apr 8. PMID: 27022999.
  8. Petersen ME, Kedei N, Lewin NE, Blumberg PM, Keck GE. Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC. Tetrahedron Lett. 2016 Oct 19;57(42):4749-4753. doi: 10.1016/j.tetlet.2016.09.040. PMID: 27713589; PMCID: PMC5047013.
  9. Baumann DO, McGowan KM, Kedei N, Peach ML, Blumberg PM, Keck GE. Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring. J Org Chem. 2016 Sep 2;81(17):7862-83. doi: 10.1021/acs.joc.6b01516. Epub 2016 Aug 23. PMID: 27494208; PMCID: PMC6957265.
  10. Ketcham JM, Volchkov I, Chen TY, Blumberg PM, Kedei N, Lewin NE, Krische MJ. Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology. J Am Chem Soc. 2016 Oct 12;138(40):13415-13423. doi: 10.1021/jacs.6b08695. Epub 2016 Sep 27. PMID: 27676096; PMCID: PMC5094189.
  11. Schneider CM, Li W, Khownium K, Lushington GH, Georg GI. Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues. ChemMedChem. 2016 Aug 5;11(15):1600-16. doi: 10.1002/cmdc.201600024. Epub 2016 May 31. PMID: 27240557; PMCID: PMC4987132.
  12. Qian S, Shah AK, Head SA, Liu JO, Jin Z. Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3411-3. doi: 10.1016/j.bmcl.2016.06.057. Epub 2016 Jun 22. PMID: 27374243; PMCID: PMC5013146.
  13. Leverett CA, Sukuru SC, Vetelino BC, Musto S, Parris K, Pandit J, Loganzo F, Varghese AH, Bai G, Liu B, Liu D, Hudson S, Doppalapudi VR, Stock J, O’Donnell CJ, Subramanyam C. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004. doi: 10.1021/acsmedchemlett.6b00274. PMID: 27882198; PMCID: PMC5108041.
  14. Zhang L, Jiang CS, Gao LX, Gong JX, Wang ZH, Li JY, Li J, Li XW, Guo YW. Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity. Bioorg Med Chem Lett. 2016 Feb 1;26(3):778-781. doi: 10.1016/j.bmcl.2015.12.097. Epub 2015 Dec 29. PMID: 26774579.
  15. Reddy DN, Ballante F, Chuang T, Pirolli A, Marrocco B, Marshall GR. Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1613-33. doi: 10.1021/acs.jmedchem.5b01632. Epub 2016 Jan 7. PMID: 26681404.
  16. Rujirawanich J, Kim S, Ma AJ, Butler JR, Wang Y, Wang C, Rosen M, Posner B, Nijhawan D, Ready JM. Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives. J Am Chem Soc. 2016 Aug 24;138(33):10561-70. doi: 10.1021/jacs.6b05484. Epub 2016 Aug 9. PMID: 27459345; PMCID: PMC5004353.


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