English

栁田 亮 (Ryo C. Yanagita), Ph.D.
香川県木田郡三木町池戸2393 香川大学農学部ケミカルバイオロジー研究室
Tel & Fax: +81 (87) 891-3092
Email: yanagita.ryo@kagawa-u.ac.jp

Last Updated: August, 2021

Research Interest:

  • 天然物を基にした医薬品シードの開発
  • 生理活性天然物の作用機構の解析
  • コンピュータを用いた薬剤の合理的設計

Education:

  • 2006–2009 京都大学博士（農学），京都大学大学院農学研究科，入江一浩教授
  • 2004–2006 修士（農学）， 京都大学大学院農学研究科，大東肇教授，入江一浩教授
  • 2000–2004 学士（農学），京都大学農学部，西岡孝明教授

Position:

  • 10/2016–  香川大学 農学部 応用生物科学科 准教授
  • 10/2010–9/2016  香川大学 農学部 応用生物科学科 助教
  • 4/2010–9/2010 京都大学 非常勤講師

Postdoctoral Training:

  • 4/2010–9/2010 博士研究員，京都大学大学院農学研究科，入江一浩教授
  • 4/2009–3/2010 日本学術振興会特別研究員 (PD)，京都大学大学院農学研究科

Predoctoral Training :

  • 4/2008–3/2009 日本学術振興会特別研究員 (DC2)， 京都大学大学院農学研究科
  • 2004–2009 ティーチングアシスタント，京都大学大学院農学研究科

Membership:

  • 2004–  日本農芸化学会
  • 2013–  アメリカ化学会
  • 2019–  有機合成化学協会

PUBLICATION:
査読付き論文

  1. Synthesis and inhibitory activity of deoxy-D-allose amide derivative against plant growth.
    Md. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami.
    Biosci. Biotechnol. Biochem. 2018, 82 (5), 775–779. [DOI: 10.1080/09168451.2018.1445521] [Pubmed: 29513080]
  2. Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.
    Yusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie.
    Molecules 2017, 22 (4), E631. [DOI: 10.3390/molecules22040631] [Pubmed: 28406454]
  3. Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure–activity study on simplified analogs of the receptor-recognition domain.
    Yoshiki Ashida, Ryo C. Yanagita, Chise Takahashi, Yasuhiro Kawanami, Kazuhiro Irie.
    Bioorg. Med. Chem. 2016, 24  (18), 4218-4227. [DOI: 10.1016/j.bmc.2016.07.011] [Pubmed: 27436807]
  4. Syntheses and biological activities of deoxy-D-allose fatty acid ester analogs.
    Md. Tazul Islam Chowdhury, Hikaru Ando, Ryo C. Yanagita, Yasuhiro Kawanami.
    Biosci. Biotechnol. Biochem. 2016, 80 (4), 676-681. [DOI: 10.1080/09168451.2015.1132151] [Pubmed: 26822163]
  5. Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead.
    Masayuki Kikumori, Ryo C. Yanagita, Harukuni Tokuda, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie.
    Biosci. Biotechnol. Biochem. 2016, 80 (2) 221-231. [DOI: 10.1080/09168451.2015.1091718] [Pubmed: 26452398]
  6. Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities.
    Yusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie.
    Biosci. Biotechnol. Biochem. 2015, 79 (6) 888-895. [DOI: 10.1080/09168451.2014.1002452] [Pubmed: 25612633]
  7. Effect of BF3 on the enantioselective reduction of trifluoromethyl ketones using a chiral lactam alcohol with borane.
    Yuki Harauchi, Chihiro Takakura, Toshio Furumoto, Ryo C. Yanagita, Yasuhiro Kawanami.
    Tetrahedron: Asymmetry 2015, 26 (7) 333-337. [DOI: 10.1016/j.tetasy.2015.02.011]
  8. Synthesis of 6-O-decanoyl-D-altrose and 6-O-decanoyl-D-gulose and evaluation of their biological activity on plant growth.
    Md. Tazul Islam Chowdhury, Madoka Naito, Ryo C. Yanagita, Yaushiro Kawanami.
    Plant Growth Regul. 2015, 75 (3) 707-713. [DOI: 10.1007/s10725-014-9972-2]
  9. Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug.
    Masayuki Kikumori, Ryo C. Yanagita, Kazuhiro Irie.
    Tetrahedron 2014, 70 (52) 9776-9782. [DOI: 10.1016/j.tet.2014.11.026]
  10. Anti-proliferative activity of 6-O -acyl-D-allose against the human leukemia MOLT-4F cell line.
    Ryo C. Yanagita, Katsuya Kobashi, Chisa Ogawa, Yoshiki Ashida, Haruka Yamaashi, Yasuhiro Kawanami.
    Biosci. Biotechnol. Biochem. 2014,  78 (2) 190-194. [DOI: 10.1080/09168451.2014.882747] [Pubmed: 25036670]
  11. Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction.
    Yuming Wang, Jiahui Wang, Ryo C. Yanagita, Chunhua Liu, Xiaoqian Hu, Ping Dong, Changhu Xue, Yong Xue.
    Biosci. Biotechnol. Biochem. 2014, 78 (1) 139-146. [DOI: 10.1080/09168451.2014.877830] [Pubmed: 25036496]
  12. Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.
    Ryo C. Yanagita, Hiroaki Kamachi, Masayuki Kikumori, Harukuni Tokuda, Nobutaka Suzuki, Kiyotake Suenaga, Hiroshi Nagai, Kazuhiro Irie.
    Bioorg. Med. Chem. Lett. 2013, 23 (15) 4319-4323. [DOI: 10.1016/j.bmcl.2013.05.096] [Pubmed: 23803585]
  13. Structure–activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.
    Hiroaki Kamachi, Keisuke Tanaka, Ryo C. Yanagita, Akira Murakami, Kazuma Murakami, Harukuni Tokuda, Nobutaka Suzuki, Yu Nakagawa, Kazuhiro Irie.
    Bioorg. Med. Chem. 2013, 21 (10) 2695-2702. [DOI: 10.1016/j.bmc.2013.03.013] [Pubmed: 23582444]
  14. Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures.
    Yuki Shu, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Kazuhiro Irie.
    Heterocycles 2012, 8 6 (1) 281-303. [DOI: 10.3987/COM-12-S(N)8]
  15. Identification and biolofical activities of bryostatins from Japanese bryozoan.
    Sayo Ueno. Ryo C. Yanagita, Kazuma Murakami, Akira Murakami, Harukuni Tokuda, Nobutaka Suzuki, Takeshi Fujiwara, Kazuhiro Irie.
    Biosci. Biotechnol. Biochem. 2012, 76 (5) 1041-1043. [DOI: 10.1271/bbb.120026] [Pubmed: 22738985]
  16. Structure–activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activit y.
    Masayuki Kikkumori. Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Kazuhiro Irie.
    J. Med. Chem. 2012, 55 (11) 5614-5626. [DOI: 10.1021/jm300566h] [Pubmed: 22625994]
  17. Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1.
    Kazuhiro Irie, Masayuki Kikumori, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Yu Nakagawa.
    Pure Appl. Chem. 2012, 84 (6) 1341-1351. [DOI: 10.1351/PAC-CON-11-08-22]
  18. Enantioselective reduction of α,β-enones using an oxazaborolidine catalyst generated in situ from a chiral lactam alcohol.
    Yasuhiro Kawanami, Yudai Mikami, Kazuya Kiguchi, Yuki Harauchi, Ryo C. Yanagita.
    Tetrahedron: Asymmetry   2011, 22 (20—22), 1891–1894. [DOI: 10.1016/j.tetasy.2011.10.018]
  19. Generation of ‘unnatural natural product’ library and identification of a small molecule inhibitor of XIAP.
    Tatsuro Kawamura, Kohei Matsubara, Hitomi Otaka, Etsu Tashiro, Kazutoshi Shindo, Ryo C. Yanagita, Kazuhiro Irie, Masaya Imoto.
    Bioorg. Med. Chem. 2011, 19 (14), 4377–4385. [DOI: 10.1016/j.bmc.2011.05.009]  [PubMed: 21696964]
  20. Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an antiproliferative analogue of tumor-promoting aplysiatoxin.
    Yu Nakagawa, Masayuki Kikumori, Ryo C. Yanagita, Akira Murakami, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie.
    Biosci. Biotechnol. Biochem. 2011, 75 (6),   1167–1173.   [DOI: 10.1271/bbb.110130] [PubMed: 21670518]
  21. Role of the phenolic hydroxyl Group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
    Ryo C. Yanagita, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Yu Nakagawa, Harukuni Tokuda, Hiroshi Nagai, Kazuhiro Irie.
    Bioorg. Med. Chem. Lett. 2010, 20 (20), 6064–6066.   [DOI: 10.1016/j.bmcl.2010.08.051] [PubMed: 20817520]
  22. A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-like activity.
    Yu Nakagawa, Ryo C. Yanagita, Naoko Hamada, Akira Murakami, Hideyuki Takahashi, Naoaki Saito, Hiroshi Nagai, Kazuhiro Irie.
    J. Am. Chem. Soc. 2009, 131 (22), 7573–7579.  [DOI: 10.1021/ja808447r] [PubMed: 19449873]
  23. Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes.
    Ryo C. Yanagita, Yu Nakagawa, Nobuhiro Yamanaka, Kaori Kashiwagi, Naoaki Saito, Kazuhiro Irie.
    J. Med. Chem. 2008, 51 (1), 46–56.   [DOI: 10.1021/jm0706719] [PubMed: 18072722]
  24. Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes.
    Ryo C. Yanagita, Keiji Torii, Yu Nakagawa, Kazuhiro Irie.
    Heterocycle 2007, 73, 289–302.  [DOI: 10.3987/COM-07-S(U)3]
  25. Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase Cε and η.
    Yu Nakagawa, Kazuhiro Irie, Ryo C. Yanagita, Hajime Ohigashi,Ken-ichiro Tsuda, Kaori Kashiwagi, Naoaki Saito.
    J. Med. Chem. 2006, 49 (4), 2981–2688.  [DOI: 10.1021/jm050857c] [PubMed: 16640328]
  26. Three genomes differentially contribute to the biosynthesis of benzoxazinones in hexaploid wheat.
    Taiji Nomura, Atsushi Ishihara, Ryo C. Yanagita, Takashi R. Endo, Hajime Iwamura.
    Proc. Natl. Acad. Sci. USA 2005, 102 (45), 16490–16495.  [DOI: 10.1073/pnas.0505156102] [PubMed: 16260753]
  27. Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCδ C1B domain: Application for the structural optimization of the PKCδ ligand.
    Yu Nakagawa, Kazuhiro Irie, Ryo C. Yanagita, Hajime Ohigashi, Ken-ichiro Tsuda.
    J. Am. Chem. Soc. 2005, 127 (16), 5746–5747.  [DOI: 10.1021/ja050447d] [PubMed: 15839646]

Book Chapters and Reviews

  1. Practical Enantioselective Reduction of Ketones Using Oxazaborolidine Catalysts Generated In Situ from Chiral Lactam Alcohols.
    Yasuhiro Kawanami, Ryo C. Yanagita.
    Molecules 2018, 23 (10), E2408. [DOI: 10.3390/molecules23102408] [Pubmed: 30241305]
  2. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.
    Kazuhiro Irie, Ryo C. Yanagita.
    Chem. Rec. 2014, 14 (2), 251–267.   [DOI: 10.1002/tcr.201300036] [PubMed: 24677503]
  3. Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism for protein kinase Cδ.
    Kazuhiro Irie, Ryo C. Yanagita, Yu Nakagawa.
    Med. Res. Rev. 2012, 32 (3), 518–535.  [DOI: 10.1002/med.20220] [PubMed: 21064191]