Simplified analogues of natural products published in 2020

Google Scholar and PubMed search results for “”simplified analogue” natural products”, “”simplified analogues” natural products”, “”simplified-analog” natural products”, “”simplified analogs” natural products”, “”function-oriented-synthesis” natural products”, and “pseudo-natural-products”. 

  1. Wakamiya Y, Ebine M, Matsumori N, Oishi T. Total Synthesis of Amphidinol 3: A General Strategy for Synthesizing Amphidinol Analogues and Structure-Activity Relationship Study. J Am Chem Soc. 2020 Feb 19;142(7):3472-3478. doi: 10.1021/jacs.9b11789. Epub 2020 Feb 6. PMID: 31986250.
  2. Moyo P, Shamburger W, van der Watt ME, Reader J, de Sousa ACC, Egan TJ, Maharaj VJ, Bringmann G, Birkholtz LM. Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:51-58. doi: 10.1016/j.ijpddr.2020.05.003. Epub 2020 May 24. PMID: 32505117; PMCID: PMC7270141.
  3. Wollnitzke P, Essig S, Gölz JP, von Schwarzenberg K, Menche D. Total Synthesis of Ajudazol A by a Modular Oxazole Diversification Strategy. Org Lett. 2020 Aug 21;22(16):6344-6348. doi: 10.1021/acs.orglett.0c02188. Epub 2020 Aug 6. PMID: 32806171.
  4. Wender PA, Sloane JL, Luu-Nguyen QH, Ogawa Y, Shimizu AJ, Ryckbosch SM, Tyler JH, Hardman C. Function-Oriented Synthesis: Design, Synthesis, and Evaluation of Highly Simplified Bryostatin Analogues. J Org Chem. 2020 Dec 4;85(23):15116-15128. doi: 10.1021/acs.joc.0c01988. Epub 2020 Nov 17. PMID: 33200928.
  5. Hardman C, Ho S, Shimizu A, Luu-Nguyen Q, Sloane JL, Soliman MSA, Marsden MD, Zack JA, Wender PA. Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy. Nat Commun. 2020 Apr 20;11(1):1879. doi: 10.1038/s41467-020-15742-7. PMID: 32312992; PMCID: PMC7170889.
  6. Catinella G, Mattio LM, Musso L, Arioli S, Mora D, Beretta GL, Zaffaroni N, Pinto A, Dallavalle S. Structural Requirements of Benzofuran Derivatives Dehydro-δ– and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes. Int J Mol Sci. 2020 Mar 21;21(6):2168. doi: 10.3390/ijms21062168. PMID: 32245220; PMCID: PMC7139904.
  7. Kavianinia I, Stubbing LA, Abbattista MR, Harris PWR, Smaill JB, Patterson AV, Brimble MA. Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127135. doi: 10.1016/j.bmcl.2020.127135. Epub 2020 Mar 23. PMID: 32229061.
  8. Scheeff S, Rivière S, Ruiz J, Abdelrahman A, Schulz-Fincke AC, Köse M, Tiburcy F, Wieczorek H, Gütschow M, Müller CE, Menche D. Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. J Med Chem. 2020 Feb 27;63(4):1684-1698. doi: 10.1021/acs.jmedchem.9b01887. Epub 2020 Feb 13. PMID: 31990540.
  9. Rivière S, Vielmuth C, Ennenbach C, Abdelrahman A, Lemke C, Gütschow M, Müller CE, Menche D. Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids. ChemMedChem. 2020 Jul 20;15(14):1348-1363. doi: 10.1002/cmdc.202000154. Epub 2020 Jun 10. PMID: 32363789; PMCID: PMC7496434.
  10. Betori RC, Liu Y, Mishra RK, Cohen SB, Kron SJ, Scheidt KA. Targeted Covalent Inhibition of Telomerase. ACS Chem Biol. 2020 Mar 20;15(3):706-717. doi: 10.1021/acschembio.9b00945. Epub 2020 Feb 24. PMID: 32017522; PMCID: PMC7233141.
  11. Kobayashi T, Yanagita RC, Irie K. Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/π interaction. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127657. doi: 10.1016/j.bmcl.2020.127657. Epub 2020 Oct 29. PMID: 33130291.
  12. Brosowsky J, Lutterbeck M, Liebich A, Keller M, Herp D, Vogelmann A, Jung M, Breit B. Syntheses of Thailandepsin B Pseudo-Natural Products: Access to New Highly Potent HDAC Inhibitors via Late-Stage Modification. Chemistry. 2020 Dec 9;26(69):16241-16245. doi: 10.1002/chem.202002449. Epub 2020 Nov 3. PMID: 32725698; PMCID: PMC7756392.
  13. Clanton NA, Hastings SD, Foultz GB, Contreras JA, Yee SS, Arman HD, Risinger AL, Frantz DE. Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides. ACS Med Chem Lett. 2020 Nov 20;11(12):2534-2543. doi: 10.1021/acsmedchemlett.0c00534. PMID: 33335677; PMCID: PMC7734803.
  14. Li RX, Han R, Wu GJ, Han FS, Gao JM. Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators. Mar Drugs. 2020 Jun 11;18(6):306. doi: 10.3390/md18060306. PMID: 32545418; PMCID: PMC7345552.
  15. Yanagimoto T, Kishimoto S, Kasai Y, Matsui N, Kubo M, Yamamoto H, Fukuyama Y, Imagawa H. Design and synthesis of dual active neovibsanin derivatives based on a chemical structure merging method. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127497. doi: 10.1016/j.bmcl.2020.127497. Epub 2020 Aug 12. PMID: 32800919.


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