Simplified analogues of natural products published in 2021

Google Scholar and PubMed search results for “”simplified analogue” natural products”, “”simplified analogues” natural products”, “”simplified-analog” natural products”, “”simplified analogs” natural products”, “”function-oriented-synthesis” natural products”, and “pseudo-natural-products”. 

1. Abegg D, Tomanik M, Qiu N, Pechalrieu D, Shuster A, Commare B, Togni A, Herzon SB, Adibekian A. Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. PMID: 34817176.
2. Milani G, Cavalluzzi MM, Solidoro R, Salvagno L, Quintieri L, Di Somma A, Rosato A, Corbo F, Franchini C, Duilio A, Caputo L, Habtemariam S, Lentini G. Molecular Simplification of Natural Products: Synthesis, Antibacterial Activity, and Molecular Docking Studies of Berberine Open Models. Biomedicines. 2021 Apr 22;9(5):452. doi: 10.3390/biomedicines9050452. PMID: 33922200; PMCID: PMC8146520.
3. Kitamura T, Suzuki R, Inuki S, Ohno H, McPhail KL, Oishi S. Design of Coibamide A Mimetics with Improved Cellular Bioactivity. ACS Med Chem Lett. 2021 Dec 29;13(1):105-110. doi: 10.1021/acsmedchemlett.1c00591. PMID: 35059129; PMCID: PMC8762706.
4. Nasufović V, Küllmer F, Bößneck J, Dahse HM, Görls H, Bellstedt P, Stallforth P, Arndt HD. Total Synthesis and Bioactivity Mapping of Geodiamolide H. Chemistry. 2021 Aug 11;27(45):11633-11642. doi: 10.1002/chem.202100989. Epub 2021 Jun 25. PMID: 34032329; PMCID: PMC8453818.
5. Yu B, Yao ZJ. A gram-scale laboratory synthesis of Annonaceous acetogenin mimic AA005. Chin Chem Lett. 2021;21(1):408-412. doi: 10.1016/j.cclet.2020.06.007.
6. Gonda A, Takada K, Yanagita RC, Dan S, Irie K. Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities. Biosci Biotechnol Biochem. 2021 Jan 7;85(1):168-180. doi: 10.1093/bbb/zbaa024. PMID: 33577665.
7. Ma Z, Huang Y, Wan K, Zhu F, Sheng C, Chen S, Liu D, Dong G. Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents. Bioorg Med Chem Lett. 2021 May 15;40:127954. doi: 10.1016/j.bmcl.2021.127954. Epub 2021 Mar 17. PMID: 33744440.
8. Emmetiere F, Ratnayake R, Schares HAM, Jones KFM, Bevan-Smith E, Luesch H, Harki DA, Grenning AJ. Function-Oriented and Modular (±)-cis-Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF-κB Inhibitors. Chemistry. 2021 Mar 22;27(17):5564-5571. doi: 10.1002/chem.202100038. Epub 2021 Feb 26. PMID: 33502811; PMCID: PMC8195264.
9. Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature. 2021 Jan;589(7842):474-479. doi: 10.1038/s41586-020-3008-z. Epub 2020 Dec 9. PMID: 33299186; PMCID: PMC7874389.
10. Utomo DH, Fujieda A, Tanaka K, Takahashi M, Futaki K, Tanabe K, Kigoshi H, Kita M. The C29-C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags. Chem Commun (Camb). 2021 Oct 12;57(81):10540-10543. doi: 10.1039/d1cc04259a. PMID: 34553712.
11. Pipaliya BV, Trofimova DN, Grange RL, Aeluri M, Deng X, Shah K, Craig AW, Allingham JS, Evans PA. Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix. J Am Chem Soc. 2021 May 12;143(18):6847-6854. doi: 10.1021/jacs.0c12404. Epub 2021 May 3. PMID: 33938740.