Simplified analogues of natural products published in 2017

Google Scholar search results for “”simplified analogue” natural products”, “”simplified analogues” natural products”, “”simplified-analog” natural products”, “”simplified analogs” natural products”, “”function-oriented-synthesis” natural products”, and “pseudo-natural-products”

  1. Jans PE, Mfuh AM, Arman HD, Shaffer CV, Larionov OV, Mooberry SL. Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues. J Nat Prod. 2017 Mar 24;80(3):676-683. doi: 10.1021/acs.jnatprod.6b00963. Epub 2017 Jan 4. PMID: 28051860; PMCID: PMC5737773.
  2. Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, Saito N, Yanagita RC, Irie K. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules. 2017 Apr 13;22(4):631. doi: 10.3390/molecules22040631. PMID: 28406454; PMCID: PMC6153940.
  3. Lu X, Pan X, Yang Y, Ji M, Chen X, Xiao Z, Liu Z. Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carboline moieties. Eur J Med Chem. 2017 Jul 28;135:260-269. doi: 10.1016/j.ejmech.2017.04.061. Epub 2017 Apr 24. PMID: 28456034.
  4. Schäfer A, Köhler SC, Lohe M, Wiese M, Hiersemann M. Synthesis of Homoverrucosanoid-Derived Esters and Evaluation as MDR Modulators. J Org Chem. 2017 Oct 6;82(19):10504-10522. doi: 10.1021/acs.joc.7b02012. Epub 2017 Sep 26. PMID: 28949536.
  5. Eiden CG, Aldrich CC. Synthesis of a 3-Amino-2,3-dihydropyrid-4-one and Related Heterocyclic Analogues as Mechanism-Based Inhibitors of BioA, a Pyridoxal Phosphate-Dependent Enzyme. J Org Chem. 2017 Aug 4;82(15):7806-7819. doi: 10.1021/acs.joc.7b00847. Epub 2017 Jul 26. PMID: 28682613; PMCID: PMC5590672.
  6. Daub ME, Prudhomme J, Ben Mamoun C, Le Roch KG, Vanderwal CD. Antimalarial Properties of Simplified Kalihinol Analogues. ACS Med Chem Lett. 2017 Feb 16;8(3):355-360. doi: 10.1021/acsmedchemlett.7b00013. PMID: 28337330; PMCID: PMC5346982.
  7. Richers J, Pöthig A, Herdtweck E, Sippel C, Hausch F, Tiefenbacher K. Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues. Chemistry. 2017 Mar 2;23(13):3178-3183. doi: 10.1002/chem.201605362. Epub 2017 Feb 7. PMID: 28067432.
  8. Solinski AE, Koval AB, Brzozowski RS, Morrison KR, Fraboni AJ, Carson CE, Eshraghi AR, Zhou G, Quivey RG Jr, Voelz VA, Buttaro BA, Wuest WM. Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms. J Am Chem Soc. 2017 May 31;139(21):7188-7191. doi: 10.1021/jacs.7b03879. Epub 2017 May 17. PMID: 28502178; PMCID: PMC5891724.
  9. Moreels L, Bhat C, Voráčová M, Peigneur S, Goovaerts H, Mäki-Lohiluoma E, Zahed F, Pardo LA, Yli-Kauhaluoma J, Kiuru P, Tytgat J. Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel KV10.1. PLoS One. 2017 Dec 8;12(12):e0188811. doi: 10.1371/journal.pone.0188811. PMID: 29220359; PMCID: PMC5722316.
  10. Kotoku N, Ito A, Shibuya S, Mizuno K, Takeshima A, Nogata M, Kobayashi M. Short-step synthesis and structure-activity relationship of cortistatin A analogs. Tetrahedron. 2017 Mar 9;73(10):1342-1349. doi: 10.1016/j.tet.2017.01.042.
  11. Tahara T, Streit U, Pelish HE, Shair MD. STAT3 Inhibitory Activity of Structurally Simplified Withaferin A Analogues. Org Lett. 2017 Apr 7;19(7):1538-1541. doi: 10.1021/acs.orglett.7b00332. Epub 2017 Mar 28. PMID: 28350459.
  12. Gould ER, King EFB, Menzies SK, Fraser AL, Tulloch LB, Zacharova MK, Smith TK, Florence GJ. Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins. Bioorg Med Chem. 2017 Nov 15;25(22):6126-6136. doi: 10.1016/j.bmc.2017.01.021. Epub 2017 Jan 28. PMID: 28185724.
  13. Roldán S, Cardona A, Conesa L, Murga J, Falomir E, Carda M, Marco JA. Synthesis and biological evaluation of simplified pironetin analogues with modifications in the side chain and the lactone ring. Org Biomol Chem. 2017 Jan 7;15(1):220-232. doi: 10.1039/c6ob01585a. Epub 2016 Nov 22. PMID: 27901163.
  14. Cartmell C, Evans DM, Elwood JML, Fituri HS, Murphy PJ, Caspari T, Poniedziałek B, Rzymski P. Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. Toxicol In Vitro. 2017 Oct;44:172-181. doi: 10.1016/j.tiv.2017.07.007. Epub 2017 Jul 10. PMID: 28705760.


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